Immunologic Effects of Heparin Associated With Hemodialysis: Focus on Heparin-Induced Thrombocytopenia

Warkentin, Theodore E.

doi:10.1016/j.semnephrol.2023.151479

Cited by 6 publications

(1 citation statement)

References 79 publications

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“…Anticoagulation in such patients may, paradoxically, result in increased complication rates or mortality [6]. In contrast, patients undergoing HD are prone to hypercoagulability, which can be associated with increased thrombotic complications [7,8]. Therefore, warfarin should be used carefully in patients undergoing HD.…”

Section: Introductionmentioning

confidence: 99%

Clinical Impact of the Use of Warfarin in Patients with Atrial Fibrillation Undergoing Maintenance Hemodialysis

Kang,

Kim,

Kim

et al. 2024

JCM

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Background: We evaluated the impact of warfarin use on the clinical outcomes of patients with atrial fibrillation who were undergoing hemodialysis (HD). Methods: A retrospective analysis was conducted utilizing data from patients undergoing maintenance HD who participated in HD quality assessment programs. Patients who were assigned the diagnostic code for atrial fibrillation (n = 4829) were included and divided into two groups based on the use of warfarin: No group (no warfarin prescriptions (n = 4009)), and Warfarin group (warfarin prescriptions (n = 820)). Results: Cox regression analyses revealed that the hazard ratio for all-cause mortality in the Warfarin group was 1.15 (p = 0.005) in univariate analysis and 1.11 (p = 0.047) in multivariable analysis compared to that of the No group. Hemorrhagic stroke was significantly associated with warfarin use, but no significant association between the use of warfarin and ischemic stroke or cardiovascular events was observed. The subgroup results demonstrated similar trends. Conclusions: Warfarin use is associated with a higher risk of all-cause mortality and hemorrhagic stroke, and has a neutral effect on ischemic stroke and cardiovascular events in patients with atrial fibrillation who are undergoing HD, compared to those who are not using warfarin.

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Section: Introductionmentioning

confidence: 99%