Immunologic Function of Dendritic Cells in Esophageal Cancer

Yang, Wenyan; J, Yu

doi:10.1007/s10620-007-0095-8

Cited by 14 publications

(12 citation statements)

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“…[44][45][46] The importance of dendritic cells in immune surveillance suggests that infiltration of dendritic cells into tumors should have prognostic significance, [44][45][46] but this has not been a consistent finding. An increased infiltration of dendritic cells into esophageal squamous cell carcinoma and hepatocellular carcinoma is associated with good prognosis for patients with such cancers, [47][48][49] but there was no significant association with prognosis in two studies of patients with renal cell carcinoma, for example. [50][51][52] As an explanation for these variable findings, Mailliard et al 53 suggest that infiltrating dendritic cells might promote T-cell survival or death, depending on their maturation stage and function.…”

Section: Discussionmentioning

confidence: 96%

Dendritic Cells in Barrett’s Esophagus and Esophageal Adenocarcinoma

Bobryshev

Tran

Killingsworth³

et al. 2009

Journal of Gastrointestinal Surgery

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Background Like other premalignant conditions that develop in the presence of chronic inflammation, the development and progression of Barrett's esophagus is associated with the development of an immune response, but how this immune response is regulated is poorly understood. A comprehensive literature search failed to find any report of the presence of dendritic cells in Barrett's intestinal metaplasia and esophageal adenocarcinoma and this prompted our study. Material and Methods We used immunohistochemical staining and electron microscopy to examine whether dendritic cells are present in Barrett's esophagus and esophageal adenocarcinoma. Immunohistochemical staining with CD83, a specific marker for dendritic cells, was performed on paraffin-embedded sections of Barrett's intestinal metaplasia (IM, n=12), dysplasia (n=11) and adenocarcinoma (n=14). Results CD83+ cells were identified in the lamina propria surrounding intestinal type glands in Barrett's IM, dysplasia, and cancer tissues. Computerized quantitative analysis showed that the numbers of dendritic cells were significantly higher in cancer tissues. Double immunostaining with CD83, CD20, and CD3, and electron microscopy demonstrated that dendritic cells are present in Barrett's esophagus and form clusters with T cells and B cells directly within the lamina propria. Conclusions These findings demonstrate that dendritic cells are present in Barrett's tissues, with a significant increase in density in adenocarcinoma compared to benign Barrett's esophagus. Dendritic cells may have a role in the pathogenesis and immunotherapy treatment of Barrett's esophagus and adenocarcinoma.

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Section: Discussionmentioning

confidence: 96%

Dendritic Cells in Barrett’s Esophagus and Esophageal Adenocarcinoma

Bobryshev

Tran

Killingsworth³

et al. 2009

Journal of Gastrointestinal Surgery

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“…In EC, it is also reported that tumor microenvironment has a close relationship with tumor growth. The cells, including NK cells, T cells, B cells, plasma cells, monocytes, macrophages, dendritic cells, mast cells, eosinophils, and neutrophils, have all been reported to have exhibited significant association with EC treatment [7,10,[25][26][27][28][29][30][31][32]. The elevation or reduction of these different types of TIICs in tumor microenvironment is commonly associated with poor prognosis of EC.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of Tumor-Infiltrating Immune Cells and Relevant Therapeutic Strategy in Esophageal Cancer

Chen

et al. 2020

Disease Markers

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A growing body of evidence has indicated that behaviors of cancers are defined by not only intrinsic activities of tumor cells but also tumor-infiltrating immune cells (TIICs) in the tumor microenvironment. However, it still lacks a well-structured and comprehensive analysis of TIICs and its therapeutic value in esophageal cancer (EC). The proportions of 22 TIICs were evaluated between 150 normal tissues and 141 tumor tissues of EC by the CIBERSORT algorithm. Besides, correlation analyses between proportions of TIICs and clinicopathological characters, including age, gender, histologic grade, tumor location, histologic type, LRP1B mutation, TP53 mutation, tumor stage, lymph node stage, and TNM stage, were conducted. We constructed a risk score model to improve prognostic capacity with 5 TIICs by least absolute shrinkage and selection operator (lasso) regression analysis. The risk score=−1.86∗plasma+2.56∗T cell follicular helper−1.37∗monocytes−3.64∗activated dendritic cells−2.24∗resting mast cells (immune cells in the risk model mean the proportions of immune cell infiltration in EC). Patients in the high-risk group had significantly worse overall survival than these in the low-risk group (HR: 2.146, 95% CI: 1.243-3.705, p=0.0061). Finally, we identified Semustine and Sirolimus as two candidate compounds for the treatment of EC based on CMap analysis. In conclusion, the proportions of TIICs may be important to the progression, prognosis, and treatment of EC.

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“…Importantly, no side effects were seen against normal cells, meaning that tolerance towards normal antigens was maintained [76]. The importance of the role of DCs in esophageal squamous cell carcinoma has been previously discussed by Yang et al [77]. Several experimental immunotherapies for esophageal cancer, such as cancer vaccine by fusions of esophageal cancer cells with DCs, DC vaccines pulsed with MAGE-3, MAGE-4, or SART-1 peptide, have been explored.…”

Section: Results From Clinical Trials Using DC Immunotherapymentioning

confidence: 99%