Immunologic mechanisms in hypersensitivity pneumonitis *1I. Evidence for cell-mediated immunity and complement fixation in pigeon breeders' disease

Caldwell, Jacques R.; Pearce, David E.; Spencer, Craig; Leder, R.O.; Waldman, Robert H.

doi:10.1016/0091-6749(73)90060-2

Cited by 81 publications

(16 citation statements)

References 3 publications

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“…However, in the same study, an indirect assay of peripheral blood lymphocytes from symptomatic pigeon breeders was negative with both PS and PDS. In contrast, C aldw ell et al [5], using an indirect tech nique, showed significant macrophage inhibition with the lymphocytes of 4 of 5 symptomatic breeders tested with PS. As macrophage inhibition was not obtained in assays containing antigen and antibody (without lym phocytes), these authors conclude that it is likely that the observed inhibi tion by the breeders' lymphocytes is due to MIF production and not to immune complexes.…”

Section: Discussionmentioning

confidence: 98%

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Pigeon-Breeder’s Disease

Hansen

Penny²

1974

Int Arch Allergy Immunol

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The cell-mediated immune response to pigeon antigens was assessed in 12 symptomatic pigeon breeders, 14 asymptomatic breeders with precipitins, 25 asymptomatic breeders without precipitins and 10 control subjects. Significant lymphocyte stimulation by pigeon serum and/or pigeon droppings extract was obtained in 11 of the 12 symptomatic breeders but was not obtained in any of the other subjects studied. The lymphocyte response to pigeon antigens in culture is presented as the distinguishing criterion for the differentiation of symptomatic and asymptomatic pigeon breeders. This study supports a direct role for a T cell-mediated immune response to pigeon antigens in the immunopathology of pigeon-breeder’s disease.

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Section: Discussionmentioning

confidence: 98%

“…Antibodies of specific class [3,8,9], antibody titre [2,7,9], com plement activation [4,5] and lymphocyte sensitization [1,5,11,13] have been implicated in the mediation of the disease.…”

Section: Introductionmentioning

confidence: 99%

Pigeon-Breeder’s Disease

Hansen

Penny²

1974

Int Arch Allergy Immunol

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“…Because the findings in this patient were inconsistent with the findings in asthma, hypersensitivity pneumonitis was considered as a diagnosis since the patient had reported that she had a cockatoo at home. In hypersensitivity pneumonitis, a micronodular or diffuse interstitial pattern is common on chest X-ray [6]. Additionally, Reynolds (2001) described the typically broncho-alveolar lavage findings in patients with hypersensitivity pneumonitis.…”

Section: Case Reportmentioning

confidence: 99%

Bird Fancier’s Disease in a 50 Year Old Woman

Asdell¹,

Fox²

2017

JCR

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Background: Although considered a rare disease, bird fancier's disease (BFD) is actually the most common type of hypersensitivity pneumonitis. It is a disease that is historically misdiagnosed and therefore the most common sequelae often include years of suffering and side effects, as in the case of this particular patient. Case Report: This is the presentation of a 50-year-old owner of a cockatoo, who for 25 years thought that she had persistent asthma. However, after being away from her bird while on a business trip, she experienced a reprieve of her symptoms followed by their exacerbation on returning home. This led to her being correctly diagnosed with BFD. Conclusion: Asthmatic patients should be asked about environmental exposures to potential allergic antigens, especially when the asthma symptoms are persistent and chronic in nature.

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“…Organic changes are preceded by sensitization of the organism with formation of local and humoral specific antibodies which in combination with the inhaled anti gen tend to generate immune complexes. Immunological reactions include cell-me diated reactions by sensitized lymphocytes [Caldwell et al, 1973;Hansen and Penny, 1974]. Thus, the transfer of an alveolitis like disease in healthy animals was possible by an injection of sensitized lymphocytes and followed inhalation of antigen, but not by a passive transfer of antibodies alone [Fink et al, 1973;Bice et al, 1975].…”

Section: Introductionmentioning

confidence: 99%

Site and Type of Impaired Lung Function in Extrinsic Allergic Alveolitis

Petro¹,

Müller²,

Wuthe³

et al. 1980

Respiration

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We investigated 109 persons exposed and sensitized against organic antigens. 46 of them (group I) are affected with the typical clinical and roentgenological signs of allergic alveolitis. The other 59 subjects (group II) were sensitized only. Included in all examinations were immunological diagnosis by means of counterimmunoelectrophoresis, systematic interviewing for case histories, and registration of respiratory symptoms. Pulmonary function was recorded by means of the following techniques: analysis of ventilation (flow-volume indices), respiratory mechanics of the larger airways and lung (body plethysmography, esophageal balloon technique), respiratory mechanics of the small airways (closing volume, amplitude of cardiogenic oscillations), distributional analysis, diffusion analysis, blood gas analysis, and right heart catheterization. Extrinsic allergic alveolitis caused changes in lung mechanics, in airways as well as in lung tissue. The most impressive findings in allergic alveolitis are mechanical inequalities of ventilation. These inequalities may be caused by changed mechanics of overall airways indicated by obstruction parameters and by changed structure of lung tissue reflected in decreased compliance, transfer factors and increased pulmonary arterial pressure. Not only a restrictive but also an obstructive disturbance of ventilation is found. Impairments are less in sensitized persons. We find slight mechanical and ventilatory inhomogeneities. An overall airway obstruction is obvious but not to such a large extent as in allergic alveolitis. On the contrary, here the lung tissue is not affected. Compliance and diffusion are within the normal range. There is no typical functional pattern specific for the diagnosis of allergic alveolitis

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Immunologic mechanisms in hypersensitivity pneumonitis *1I. Evidence for cell-mediated immunity and complement fixation in pigeon breeders' disease

Cited by 81 publications

References 3 publications

Pigeon-Breeder’s Disease

Pigeon-Breeder’s Disease

Bird Fancier’s Disease in a 50 Year Old Woman

Site and Type of Impaired Lung Function in Extrinsic Allergic Alveolitis

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