Immunologic Mechanisms in Mosquito Allergy: Correlation of Skin Reactions with Specific IgE and IgG Antibodies and Lymphocyte Proliferation Response to Mosquito Antigens

Peng, Zhikang; Yang, Ming; Simons, F. Estelle R.

doi:10.1016/s1081-1206(10)63262-0

Cited by 94 publications

(101 citation statements)

References 31 publications

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“…IL-4 production is significantly increased while IFN-γ production is decreased in sensitized mice, suggesting that a T H 2 immune response predominates following sensitization (Chen et al 1998). Mean lymphocyte proliferation after stimulation with mosquito antigens is higher in mice (Chen et al 1998) and humans (Peng et al 1996) previously exposed to mosquito bites, implying that lymphocytes are involved in the development of immunological reactions to mosquito saliva. A shift in the immune response such as this at the site of arbovirus delivery could affect the pathogenesis of the virus.…”

Section: Host Immune Response Against Mosquito Saliva and Implicationmentioning

confidence: 99%

“…Mosquito saliva-specific IgG1 and IgE, but not IgG2a, is increased in sensitized mice, and comparisons show that most of the antigens also elicited human IgE responses. The degree of the host response to mosquito saliva is dependent on the duration and intensity of exposure to biting mosquitoes and the immunological profile of the host (Peng et al 1996). Intriguingly, the immune response to mosquito saliva affects cytokine expression.…”

Section: Host Immune Response Against Mosquito Saliva and Implicationmentioning

confidence: 99%

See 1 more Smart Citation

The enhancement of arbovirus transmission and disease by mosquito saliva is associated with modulation of the host immune response

Schneider

Higgs

2008

Transactions of the Royal Society of Tropical Medicine and Hygi

227

198

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SUMMARYArthropod-borne viruses have emerged as a major human health concern. Viruses transmitted by mosquitoes are the cause of the most serious and widespread arbovirus diseases worldwide and are ubiquitous in both feral and urban settings. Arboviruses, including dengue and West Nile virus are injected into vertebrates within mosquito saliva during mosquito feeding. Mosquito saliva contains anti-haemostatic, anti-inflammatory and immunomodulatory molecules that facilitate the acquisition of a blood-meal. Collectively, studies investigating the effects of mosquito saliva on the vertebrate immune response suggest that at high concentrations salivary proteins are immmunosuppressive, whereas lower concentrations modulate the immune response; specifically, T H 1 and antiviral cytokines are down-regulated, while T H 2 cytokines are unaffected or amplified. As a consequence, mosquito saliva can impair the anti-viral immune response thus affecting viral infectiousness and host survival. Mounting evidence suggests that this is a mechanism whereby arbovirus pathogenicity is enhanced. In a range of disease models, including various hosts, mosquito species, and arthropodborne viruses, mosquito saliva and/or feeding is associated with a potentiation of virus infection. Compared to arbovirus infection initiated in absence of the mosquito or its saliva, infection including mosquito saliva leads to an increase in virus transmission, host susceptibility, viraemia, disease progression, and mortality.Keywords arthropod-borne virus; mosquito saliva; immunomodulation; disease enhancement Most arthropod-borne (arbo)viruses of public health significance are mosquito-borne, and thus transmitted to vertebrates via the feeding of an infected mosquito. For a mosquito to

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Section: Host Immune Response Against Mosquito Saliva and Implicationmentioning

confidence: 99%

Section: Host Immune Response Against Mosquito Saliva and Implicationmentioning

confidence: 99%

The enhancement of arbovirus transmission and disease by mosquito saliva is associated with modulation of the host immune response

Schneider

Higgs

2008

Transactions of the Royal Society of Tropical Medicine and Hygi

227

198

View full text Add to dashboard Cite

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“…The serum concentrations of IgE and IgG specific for mosquito salivary gland were higher in subjects with immediate reactions to mosquito bites than in those without immediate reactions (15). Mosquito extract-induced proliferation of lymphocytes was higher in the subjects with delayed reactions than those without delayed reactions (15). Serum from patients with mosquito allergy causes immediate cutaneous reactions in mosquito bite-tolerant subjects (17).…”

mentioning

confidence: 98%

“…The bite of a mosquito whose salivary duct has been cut does not produce wheal and itching (16). The serum concentrations of IgE and IgG specific for mosquito salivary gland were higher in subjects with immediate reactions to mosquito bites than in those without immediate reactions (15). Mosquito extract-induced proliferation of lymphocytes was higher in the subjects with delayed reactions than those without delayed reactions (15).…”

mentioning

confidence: 99%

Roles of Mast Cells and Histamine in Mosquito Bite-Induced Allergic Itch-Associated Responses in Mice

Ohtsuka

Kawai

Ichikawa

et al. 2001

Japanese Journal of Pharmacology

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ABSTRACT-We investigated itch-associated responses (scratching) to mosquito bites and the role of histamine and mast cells in mosquito-induced itching in mice. Although the first bites of mosquito Aedes albopictus did not increase scratching, repeated bites increased scratching. The response was not diminished even after an interval of 2 months. Similarly, repeated intradermal (i.d.) injections of salivary gland extract (SGE) from Aedes albopictus increased scratching after SGE injection itself and mosquito bites. The scratching peaked within 10 min and almost subsided by 60 min. The opioid antagonist naloxone (1 mg / kg, s.c.) inhibited scratching following SGE injection. Although the non-sedative H 1-histamine-receptor antagonist terfenadine (30 mg/ kg, p.o.) significantly suppressed scratching induced by histamine (100 nmol /site, i.d.) in either naive or mosquito-sensitized mice, it did not affect mosquito-induced scratching in mosquitosensitized mice. Repeated injections of SGE increased scratching in mast cell-deficient (WBB6F1-W /W v ) mice as well as in normal (WBB6F1-+/ +) littermates. Repeated exposure to mosquito bites roughly doubled serum concentrations of total IgE and IgG1, but not IgG2a. Repeated injections of SGE markedly increased plasma extravasation induced by mosquito bites and such an increase was almost completely suppressed by terfenadine (30 mg/ kg, p.o.). The results show the presence of histamine-mediated and histamineindependent mechanisms in cutaneous itching and suggest that histamine probably released from mast cells does not play an important role in itching in immediate allergic reaction. Our murine model of mosquito itching may be useful for studying the mechanisms of immediate allergic itching.

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“…Este mismo periodo coincide con la etapa clínica, en la cual se presenta de manera más intensa la enfermedad. En el estudio de Peng, et al, se encontró una correlación entre los niveles de IgE específica para el extracto de saliva del mosquito y el tamaño de la induración inmediata o tardía inducida por una prueba epicutánea con la misma preparación (61).…”

Section: Respuesta Humoralunclassified

Papular urticaria: A review of causal agents in Colombia

et al. 2016

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López: análisis bioinformático y datos experimentales inéditos Todos los autores contribuyeron en igual medida a la redacción del manuscrito. La urticaria papular es una enfermedad alérgica causada por la picadura de insectos, la cual predomina en el trópico. El objetivo de esta revisión fue profundizar en sus aspectos epidemiológicos e inmunológicos, particularmente con base en datos publicados en Latinoamérica. Se hizo una revisión no sistemática mediante la búsqueda electrónica de artículos sobre la epidemiología de la urticaria papular, las características entomológicas de los agentes causales y los mecanismos inmunológicos asociados. Según los diversos reportes de centros médicos de Latinoamérica la urticaria papular es frecuente; el único estudio de prevalencia publicado indica que afecta a una cuarta parte de los niños escolares de Bogotá. Hay información sobre la relación causal entre la exposición domiciliaria a la pulga, la pobreza y la urticaria papular en Bogotá, una ciudad representativa de las altitudes andinas. No hay estudios que indaguen directamente sobre los insectos causales en zonas cálidas, aunque se sospecha clínicamente de los mosquitos Aedes aegypti y Culex quinquefasciatus. En cuanto a su patogenia, se destaca la participación de mecanismos celulares que involucran las células colaboradoras Th2, lo cual explica que sea una condición de hipersensibilidad retardada. El papel de la inmunoglobulina E (IgE) en la urticaria papular no está tan claro. Se desconocen los antígenos derivados de los insectos que causan la enfermedad, aunque se plantea que existen moléculas comunes de reacción cruzada entre los insectos, tales como el alérgeno Cte f 2 en la pulga, y sus homólogos en los mosquitos. La urticaria papular es una condición frecuente en Latinoamérica que debe investigarse en profundidad. La caracterización inmunológica de los componentes moleculares que causan esta condición puede resolver interrogantes sobre su etiología y su patogenia. Urticaria papular y sus agentes causales en ColombiaPalabras clave: urticaria; insectos; Aedes; Culex; Ctenocephalides; hipersensibilidad. doi: http://dx.doi.org/10.7705/biomedica.v36i4.3258 Papular urticaria: A review of causal agents in ColombiaPapular urticaria is a chronic allergic reaction induced by insect bites, which is common in the tropics. The objective of this review was to deepen on epidemiological and immunological aspects of this disease, focused on data published in Latin American countries. We conducted a non-systematic review of the literature through electronic search on the epidemiology of papular urticaria, the entomological characteristics of the causative agents and associated immunological mechanisms. Several reports from medical centers suggest that papular urticaria is common in Latin America. Only one epidemiological survey designed to estimate prevalence of papular urticaria has been published, reporting that about a quarter of children under six years of age is affected by this condition in Bogotá. There is evidence on the ca...

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Immunologic Mechanisms in Mosquito Allergy: Correlation of Skin Reactions with Specific IgE and IgG Antibodies and Lymphocyte Proliferation Response to Mosquito Antigens

Cited by 94 publications

References 31 publications

The enhancement of arbovirus transmission and disease by mosquito saliva is associated with modulation of the host immune response

The enhancement of arbovirus transmission and disease by mosquito saliva is associated with modulation of the host immune response

Roles of Mast Cells and Histamine in Mosquito Bite-Induced Allergic Itch-Associated Responses in Mice

Papular urticaria: A review of causal agents in Colombia

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