Immunologic observations in close relatives of two sisters with mammary Burkitt's lymphoma. Mammary Burkitt's lymphoma in sisters

Poulsen, Lene; Christensen, Jeppe Hagstrup; Sørensen, B. H.; Ebbesen, Peter; Pallesen, Gorm; Grunnet, Niels

doi:10.1002/1097-0142(19910901)68:5<1031::aid-cncr2820680521>3.0.co;2-s

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…Five patients with Burkitt‐like lymphoma were seen in our PBL group. Although Burkitt‐like lymphoma of the breast has been associated with pregnancy,43, 44 none of these five women was pregnant. The remaining patient with high‐grade lymphoma had lymphoblastic T‐cell lymphoma.…”

Section: Discussionmentioning

confidence: 95%

Lymphomas of the breast

Domchek

Hecht

Fleming

et al. 2001

Cancer

184

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BACKGROUND The involvement of the breast by lymphoma is a rare form of extralymph node lymphoma and represents either primary disease or systemic involvement. The authors hypothesized that screening mammography may influence the detection of lymphomatous involvement of the breast. METHODS All patients (n = 81 patients) who were diagnosed with lymphomatous involvement of the breast at the study institution between 1988 and 1999 were evaluated retrospectively. RESULTS Clinical information was available for 73 patients who could be classified into three major groups according to their diagnosis: primary breast lymphoma (PBL) (44%), breast involvement from disseminated disease at the time of initial diagnosis (29%), and recurrence of preexisting lymphoma to the breast (27%). The majority of PBL were of intermediate or high grade, and the majority of disseminated lymphomas involving the breast were of low grade. Lymphomatous recurrence to the breast was slightly more likely to be of intermediate grade rather than low grade. In 91% of patients, the diagnosis of lymphoma was made after the evaluation of a palpable mass. All patients who were identified after the evaluation of an abnormal screening mammogram (9%) had low‐grade lymphomas. Of the 32 patients with PBL, screening mammography discovered only 1. Nineteen percent of patients with PBL also had a history of an autoimmune disorder. CONCLUSIONS These findings suggest that screening mammography has not altered substantially the detection of breast lymphoma. The clinical outcome of patients with breast lymphoma is dependent on histology and appears to parallel that of patients with lymphoma of similar histology involving other sites. Cancer 2002;94:6–13. © 2002 American Cancer Society.

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Section: Discussionmentioning

confidence: 95%

Lymphomas of the breast

Domchek

Hecht

Fleming

et al. 2001

Cancer

184

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Genetic Factors in Leukemia and Lymphoma

Leòn

1994

Familial and Hereditary Tumors

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Primary Bilateral Burkitt Lymphoma of the Lactating Breast

et al. 2010

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Burkitt lymphoma (BL) is a highly aggressive neoplasm, which frequently affects the ileocecal region in the sporadic form and the jaw in the endemic form; however, the breast is a rare primary site of this tumor. Here we describe a case of primary bilateral breast BL presenting during lactation in a 23-year-old woman. Excisional biopsy of breast masses demonstrated a B-cell lymphoma with a characteristic 'starry sky' pattern highly suggestive of BL. The neoplastic cells strongly expressed CD20 and CD10, and showed proliferative activity as measured by Ki-67. An IGH-MYC gene fusion indicating the presence of a typical Burkitt translocation t(8;14)(q24;q32) in the tumor tissue was detected by fluorescent in situ hybridization. The present case, along with a comprehensive review of the literature, demonstrates that BL of the breast should be considered in the differential diagnosis of lesions of the breast during lactation. Whether hormonal or antigenic factors trigger Burkitt lymphomagenesis in the lactating breast warrants further investigation.

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Immunologic observations in close relatives of two sisters with mammary Burkitt's lymphoma. Mammary Burkitt's lymphoma in sisters

Cited by 4 publications

References 19 publications

Lymphomas of the breast

Lymphomas of the breast

Genetic Factors in Leukemia and Lymphoma

Primary Bilateral Burkitt Lymphoma of the Lactating Breast

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