Immunologic pathomechanism of Hodgkin's lymphoma

Incidence of Childhood Hodgkin Lymphoma in Mexico by Histologic Subtypes and Socioeconomic Regions

“…An explanation given for this phenomenon is the possibility of later infection by EBV, as well as differences in the immune response in this population. 18,35,36 Our data showed that the incidences of this subtype did not substantially change by region and that both values were similar to those reported for developed countries worldwide, 26 thus implying that there may exist other etiological factors, such as genetic or environmental factors distinct from early EBV infection, which are involved for this subtype.…”

INTERACTIVE CASE REPORT: Lymphoma Case Mimicking Tuberculosis

“…Hücre ilişkili immünite geniş bir şekilde lenfomada bozulmuştur. Bu nedenle gelişen immün yetmezlik EpsteinBarr virus (EBV), cytomegalovirus (CMV), herpes simpleks virus (HSV), mikobakterium tüberkülozis gibi enfeksiyonlara zemin hazırlamaktadır (8). Olgumuzun eksüda vasfında lenfosit hâkimiyetinde olan plevral sıvısı da vardı.…”

Genetic Associations in Classical Hodgkin Lymphoma: A Systematic Review and Insights into Susceptibility Mechanisms

“…Interestingly, many of the gene loci associated with susceptibility have already been causally linked to the pathogenesis of cHL in targeted studies, by altered expression levels or specific mutations (1,74,75). We recently performed a whole-exome sequencing (WES) study of five cHL cell lines and found mutations in several of the associated genes, including HLA, B2M, NFKBIA, STAT3, and STAT6 (76), again indicating that antigen presentation and the IL13 pathway are critically important in cHL pathogenesis.…”