Immunologic profile of excessive body weight

Abstract

The purpose of this paper is to identify immunologic hallmarks of excessive bodyweight. The analysis is based on 176 adults (106 women, 70 men) who participated in a nested case-control study in Italy. All participants were healthy at the time of blood collection and aged between 36 and 75 years. We employed multivariate analysis of variance and a nonparametric Bayesian additive regression tree approach along with a receiver operating characteristic (ROC) curve analysis to determine the immunologic signature of excessive body weight (i.e., obesity and overweight). Interleukin 8 (IL-8), IL-10, interferon γ, and inducible protein 10 were shown to be predictive of excessive body weight with an area under the ROC curve of 71% (p < 0.0002). We propose that by using this profile-based approach to define immunologic signatures, it might be possible to identify unique immunologic hallmarks of specific types of obesity.

Metabolic syndrome and the seminal cytokine network in morbidly obese males

“…For a broader investigation of biomarkers, some working groups applied multiplex cytokine measurements in the blood samples of MetS patients and reported a range of cytokine concentrations comparable to those measured in our study (Schipper et al, 2010;Bremer et al, 2011;Sharabiani et al, 2011;Surendar et al, 2011;Tisato et al, 2013). We identified IL-6 and IL-10 to be significantly elevated in MetS patients.…”

A review of the role of lymphoma markers and occupational and environmental exposures

“…Results of our study within the EPIC-Italy (Taghavi Azar Sharabiani et al 2011) suggested that IL8, IL10, IFN-, and IP10 are related to obesity (Body mass index; BMI). Among these predictors, IP10 had the highest prognostic value for obesity.…”

“…In the two studies described previously (Saberi Hosnijeh, Krop, Scoccianti, et al 2010;Taghavi Azar Sharabiani et al 2011), no overlap was observed between marker levels of obesity and NHL (as based on the original concept of ''meet in the middle'' approach). However, a potential role of obesity in lymphomagenesis cannot be excluded because, on one hand, several studies showed that obesity is a lowgrade chronic inflammatory state and, on the other hand, a chronic inflammatory condition has been linked to NHL risk in previous epidemiological studies (Smedby et al 2011).…”

“…Our studies (Saberi Hosnijeh, Krop, Scoccianti, et al 2010;Taghavi Azar Sharabiani et al 2011) are among the first studies that used prospectively collected samples, thus avoiding inverse causation bias in that some biomarkers might be affected by the disease process or treatment of the disease. These studies only had one prospectively collected blood sample for each individual to characterize their immune profile.…”

Impaired Glucose Tolerance, Obesity and Inflammatory Mediators

“…Recent data indicate that macrophages in obese adipose tissue are major source of most mediators. Therefore weight loss is associated with a reduction in the macrophage infiltration of adipose tissue and an improvement of the inflammatory profile [39][40][41][42][43][44][45].…”