Immunologic Reduction of Bladder Cancer Recurrence Rate

Olsson, Carl A.; Chute, Richard; Rao, Chadalawada N.

doi:10.1016/s0022-5347(17)59919-x

Cited by 89 publications

(27 citation statements)

References 25 publications

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“…Wishahi et al, reported that the incidence of recurrence in patients with TCC associated with urinary schistosomiasis was 15% after KLH treatment compared with 77% before therapy (Wishahi et al, 1995). This result was similar to the results obtained by Olson et al, (1974) and Jurincic et al, (1998) confirming the outstanding immunotherapeutic properties of KLH (Olsson et al, 1974;Jurincic et al, 1988). The efficacy of this treatment in patients with carcinoma in situ (CIS) grade 3 was studied in a long-term follow-up.…”

Section: Use Of Hemocyanins In Clinical Studies Of Sbcsupporting

confidence: 71%

“…In a 1974 delayed-type hypersensitivity (DTH) experiment to measure the immune competence of patients with TCC, Olson and collaborators reported the unexpected result that patients subcutaneously primed with 5 mg of KLH and then subcutaneous immunized with 200 µg of KLH had a significantly diminished tumor recurrence rate over a study period of two years. Those patients that were DTH positive to KLH, and therefore immune competent, had almost no recurrences (Olsson et al, 1974). This outstanding effect was confirmed many years later in a controlled study of patients in stages Ta and T1 who had previously been subject to TUR.…”

Section: Use Of Hemocyanins In Clinical Studies Of Sbcmentioning

confidence: 78%

“…Despite the successful results achieved with BCG, its serious side effects have led researchers to investigate other immunostimulatory substances. In the early 1970s, Olsson and collaborators reported that subcutaneous stimulation with keyhole limpet hemocyanin (KLH) from the Californian marine gastropod Megathura crenulata significantly reduced SBC recurrence frequency in TCC patients without any toxic side effects, making it ideal for long-term repetitive treatments (Olsson et al, 1974). These results provided promising support for the use of mollusk hemocyanins as alternative agents in SBC immunotherapy.…”

Section: Introductionmentioning

confidence: 99%

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Hemocyanins in the Immunotherapy of Superficial Bladder Cancer

Arancibia¹,

Salazar²,

Becker³

2012

Bladder Cancer - From Basic Science to Robotic Surgery

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Section: Use Of Hemocyanins In Clinical Studies Of Sbcsupporting

confidence: 71%

Section: Use Of Hemocyanins In Clinical Studies Of Sbcmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hemocyanins in the Immunotherapy of Superficial Bladder Cancer

Arancibia¹,

Salazar²,

Becker³

2012

Bladder Cancer - From Basic Science to Robotic Surgery

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“…These novel structures, together with the high levels of cross-reactivity with a variety of carbohydrate Ags, may contribute to the immunogenicity of KLH (47). In 1974, Olsson et al (48) discovered that patients immunized with KLH had a reduction in recurrence of bladder carcinomas. The cross-reactive epitope was identified (49), and clinical trials with Immucothel, a KLH subunit, are reported (50).…”

Section: Discussionmentioning

confidence: 99%

Antibodies to Keyhole Limpet Hemocyanin Cross-React with an Epitope on the Polysaccharide Capsule of Cryptococcus neoformans and Other Carbohydrates: Implications for Vaccine Development

May

Beenhouwer

Scharff

2003

The Journal of Immunology

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Cryptococcus neoformans causes a life-threatening meningoencephalitis in AIDS patients. Mice immunized with a glycoconjugate vaccine composed of the glucuronoxylomannan (GXM) component of the cryptococcal capsular polysaccharide conjugated to tetanus toxoid produce Abs that can be either protective or nonprotective. Because nonprotective Abs block the efficacy of protective Abs, an effective vaccine must focus the Ab response on a protective epitope. Mice immunized with peptide mimetics of GXM conjugated to keyhole limpet hemocyanin (KLH) with glutaraldehyde developed Abs to GXM. However, control peptides P315 and P24 conjugated to KLH also elicited Abs to GXM. GXM-binding Abs from mice immunized with P315-KLH were inhibited by KLH treated with glutaraldehyde (KLH-g), but not by P315. Furthermore, KLH-g inhibited binding of GXM by serum of mice immunized with GXM-TT, indicating that glutaraldehyde treatment of KLH reveals an epitope(s) that cross-reacts with GXM. Vaccination with KLH-g or unmodified KLH elicited Abs to GXM, but did not confer protection against C. neoformans, suggesting the cross-reactive epitope on KLH was not protective. This was supported by the finding that 4H3, a nonprotective mAb, cross-reacted strongly with KLH-g. Sera from mice immunized with either native KLH or KLH-g cross-reacted with several other carbohydrate Ags, many of which have been conjugated to KLH for vaccine development. This study illustrates how mAbs can be used to determine the efficacy of potential vaccines, in addition to describing the complexity of using KLH and glutaraldehyde in the development of vaccines to carbohydrate Ags.

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“…The hemocyanin from the mollusk keyhole limpet (Megathura crenulata), known as KLH, has been used for the above purposes. Besides these biomedical effects, KHL has been used in the diagnosis and immunotherapy of Shistosomias (Li et al, 1994), in drug addiction (Ettinger et al, 1997;Beike et al, 1997), and as a component of experimental synthetic minimal viral vaccines against AIDS (Naylor et al, 1991) and papilloma virus (Meyer et al, 1998), and exhibit also antitumour activity against different kinds of tumours (Olsson et al, 1974;Lamm et al, 2000;Jurincic-Winkler et al, 2000;Sandmaier et al, 1999;McFadden et al, 2003;Vona-Davis et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Anti-Herpes Effect of Hemocyanin Derived from the Mollusk Rapana thomasiana

Genova-Kalоu

Dundarova

Idakieva

et al. 2008

Zeitschrift Für Naturforschung C

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The cytotoxicity and the antivirus activity of native hemocyanin, RtH, derived from the Bulgarian marine mollusk Rapana thomasiana and its structural isoform, RtH2, against HSV replication was evaluated on three HSV strains Ð two wt strains, TM (HSV 1) and Bja (HSV 2), and one ACV R mutant with tk gene mutation, DD (HSV 2). The experiments were performed on continuous RD 64 cells and three HSV 1 and HSV 2 strains were used, two mutants sensitive to acyclovir and one resistant mutant.Both compounds were found to be effective inhibitors of wt HSV replication. Both compounds did not exhibit any effect on the infectious virus yield on ACV R mutant. The most promising, active and selective, anti-HSV agent, especially to genital herpes virus, was found to be the functional unit of native hemocyanin Ð RtH2. RtH2 did not induce apoptosis/ necrosis 8 h after virus infection and the target of its action, was found to be the viral but not the host cell DNA.

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Immunologic Reduction of Bladder Cancer Recurrence Rate

Cited by 89 publications

References 25 publications

Hemocyanins in the Immunotherapy of Superficial Bladder Cancer

Hemocyanins in the Immunotherapy of Superficial Bladder Cancer

Antibodies to Keyhole Limpet Hemocyanin Cross-React with an Epitope on the Polysaccharide Capsule of Cryptococcus neoformans and Other Carbohydrates: Implications for Vaccine Development

Anti-Herpes Effect of Hemocyanin Derived from the Mollusk Rapana thomasiana

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