Immunologic response to cryoablation of breast cancer

Abstract

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Regulatory T cells are associated with post-cryoablation prognosis in patients with hepatitis B virus-related hepatocellular carcinoma

“…Previous studies have suggested that cryoablation could reduce the release of immunosuppressive factors and that tumor antigens were released into the circulation from necrotic tumor cells [32], leading to elevated anti-tumor immunity, such as increased cytotoxicity of NK cells [7,8]. In the present study, Treg exerted suppressive effects on the immune system both before and after cryoablation.…”

“…Two groups have postulated that cryoablation interferes with the biological activity of tumor cells while preserving the structure of tumor antigenic proteins, which may enhance the specific anti-tumor immune response [5,6]. Sabel et al [7,8] reported that cryoablation led to the induction of both a tumor-specific T-cell response in the tumor-draining lymph node (TDLN) and increased systemic natural killer (NK) cell activity in a mouse model with mammary adenocarcinoma. These observations were correlated with findings of tumor rejection upon re-challenge in mice that had undergone cryoablation.…”

Cryoablation and Meriva have strong therapeutic effect on triple-negative breast cancer

“…However, in another breast cancer model MT-901 (murine cell line derived from dimethylbenzantracen), IFNg and IL-12 significantly increased in the serum, while IL-10 was not affected by cryoablation. 27 So far, cytokine levels in serum of patients with breast cancer after cryoablation has not been reported, but in patients with prostate cancer it was found that IFNg and TNFa significantly increased after cryoablation in the serum, 28 while in patients with hepatic cancer TNFa and IL-10 increased significantly in the serum after cryoablation. 29 In summary, these results indicate that the production of cytokines for each cancer may be different and should be analyzed for each individual patient to develop a personalized combination therapy.…”

Disappearance of lung adenocarcinoma after total en bloc spondylectomy using frozen tumor-bearing vertebra for reconstruction

“…Breast cancer cells treated with cryoablation induced a tumor-specific T cell response in mice [13]. The injection of intratumoral dendritic cells following the cryoablation of prostate cancer prolonged survival and reduced lung metastasis in mice [14].…”