Immunologic study of an oncornavirus isolated from a human cancer cell line

Abstract

An immunologic test‐system for an oncornavirus of Type B isolated from an HEp2 cell line was obtained. The virus‐specific serum detects both extracellular and intracellular antigens of the virus as well as antigens of oncornaviruses of Type B revealed in HeLa, DAPT, RH, Detroit 6, and A1 cell lines. This group‐specific antigen cross‐reacts with the antigen of the rhesus monkey oncornavirus Type B and does not cross‐react with the antigen of the mouse mammary tumor virus. No cross‐reaction was revealed between the virus studied and oncornavirus of Type C isolated from an H‐22 cell line.