Immunological and biochemical markers in preeclampsia

Kestlerová, Andrea; Feyereisl, Jaroslav; Frisová, V.; Mĕchurová, A; Sůla, K; Zima, Tomáš; Běláček, Jaromír; Madar, J

doi:10.1016/j.jri.2012.10.002

Cited by 26 publications

(30 citation statements)

References 18 publications

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“…Furthermore, these levels rise during gestation, probably because of increased synthesis (Abramson and Buyon, 1992). In preeclamptic patients, however, a significantly lower serum C3 and C4 level compared with healthy pregnancies was demonstrated, indicative of the consumption of these factors and the activation of the complement cascade (Girardi et al, 2011;Houwert-de Jong et al, 1985;Kestlerova et al, 2012). Although our results were not significantly different, we observed lower C3 and C4 levels in the preeclamptic patients (both OD and spontaneous conception).…”

Section: Discussioncontrasting

confidence: 66%

“…Mutations in genes encoding complement inhibitors are associated with an increased risk of developing preeclampsia (Salmon et al, 2011). Furthermore, the level of various complement components is decreased in sera of women with preeclampsia compared with healthy pregnant women, possibly as a result of consumption due to activation of complement (Girardi et al, 2011;Houwert-de Jong et al, 1985;Kestlerova et al, 2012). Indeed, increased deposition of complement components is observed in the placentas of preeclamptic women (Sinha et al, 1984;Tedesco et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

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Preeclampsia in autologous and oocyte donation pregnancy: is there a different pathophysiology?

Lashley

Buurma

Swings

et al. 2015

Journal of Reproductive Immunology

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Section: Discussioncontrasting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Preeclampsia in autologous and oocyte donation pregnancy: is there a different pathophysiology?

Lashley

Buurma

Swings

et al. 2015

Journal of Reproductive Immunology

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“…International Society for the study of Hypertension in Pregnancy (ISSHP) defines PE as the coexistence of one or more of the following new onset conditions: proteinuria, other maternal organ dysfunction (renal, liver, neurological and haematological complications), and uteroplacental dysfunction (fetal growth restriction) [1]. Among several proposed theories relevant to the etiology of PE, dysfunctional immune responses have played a significant role [2]. C-reactive protein (CRP) is a major component of the innate immune response, and evidence has accumulated demonstrating a relationship between CRP levels and other indicators of inflammatory states [3,4], as well as correlations between PE [5,6] and various cardiovascular phenotypes [7].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Status Is Related to Oxidative Stress But Not High-Sensitive C-Reactive Protein in Women with Pre-Eclampsia

Gargari

Tabrizi²,

Sadien³

et al. 2015

Gynecol Obstet Invest

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Background/Aims: Pre-eclampsia (PE) is associated with unfavorable metabolic profiles. Oxidative stress and inflammation have been increasingly postulated as major contributors to PE. Research suggests that vitamin D status is disturbed in women with PE. The aims of this study were to compare the serum levels of vitamin D and oxidative stress status in women with PE vs. women with normal pregnancies, and to evaluate the relationship between these 2 factors in women with PE. Methods: In this case-control study, 40 women with PE and 40 healthy pregnant women were selected, and high-sensitivity C-reactive protein, malondialdehyde (MDA), total antioxidant capacity (TAC) and 25-hydroxyvitamin D (25(OH)D) levels were assessed. We compared the biochemical indicators between the 2 groups by analysing the data using the independent t test, Mann-Whitney U test, chi-square and logistic regression. Results: Compared with the controls, the serum levels of MDA in women with PE were significantly higher (p = 0.001) and TAC and 25(OH)D levels were significantly lower (p < 0.05). TAC concentration was positively associated with 25(OH)D levels in cases of PE (β = 0.428, p = 0.01). Conclusion: Our findings show lower levels of TAC and 25(OH)D in women with PE in comparison to controls, while having similar vitamin D intakes. In addition, our results suggest a positive relationship between TAC concentration and 25(OH)D levels in PE cases.

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“…There was significant differences of anticardiolipin IgM antibody between the preeclampsia group and the controls (8.1 vs 1.2%, p=0.041). 21 A study by Kestlerova et al (2012) found there was a significantly higher incidence of anticardiolipin IgM antibody in the preeclampsia group, as compared to the controls (10 vs 4%, p<0.05). 22 Study results done by Briones-Garduno et al (2003) recommended that immunologic mechanism that induces synthesis of anticardiolipin IgM antibody during the acute state of disease, accounting for vascular changes and prothombotic state responsible for maternal and neonatal complications.…”

Section: Discussionmentioning

confidence: 97%

“…21 A study by Kestlerova et al (2012) found there was a significantly higher incidence of anticardiolipin IgM antibody in the preeclampsia group, as compared to the controls (10 vs 4%, p<0.05). 22 Study results done by Briones-Garduno et al (2003) recommended that immunologic mechanism that induces synthesis of anticardiolipin IgM antibody during the acute state of disease, accounting for vascular changes and prothombotic state responsible for maternal and neonatal complications. 17 Allen et al (1996) found elevated levels of IgG or IgM antibodies to cardiolipin in 11% of women diagnosed with preeclampsia in the third trimester compared to only 3% positive in controls and suggested that antiphospholipid antibodies may play a pathogenic role in some women with preeclampsia.…”

Section: Discussionmentioning

confidence: 97%

Association of anticardiolipin IgM antibody with preeclampsia

Khanam

Fatima

Begum

et al. 2018

Bangabandhu Sheikh Mujib Medical University Journal

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<p class="Abstract">The objective of this study was to evaluate association of anticardiolipin IgM antibody with preeclampsia among the 70 pregnant women having preeclampsia from March 2016 to February 2017. Equal number of age matched normotensive healthy pregnant women was selected as control. Demographic, obstetric and relevant laboratory data were collected and compared between the two groups. The level of anticardiolipin IgM antibody was significantly higher in preeclamptic women than in normal pregnant (mean 8.7 vs 5.8 U/mL, p<0.001). Even in categorical distribution when the value was considered as positive by assessing a cut-off, cases had three times more chance to have positive level of anticardiolipin IgM antibody than controls (OR=3.3, 95% CI=1.1-9.6, p=0.046). Pearson’s correlation test revealed that both systolic and diastolic blood pressure had a positive correlation with the level of anticardiolipin IgM antibody. (p<0.05). In conclusion, this study shows that anticardiolipin IgM antibody was associated with preeclampsia. The level of this anticardiolipin IgM antibody is directly proportional to the severity of preeclampsia and both systolic and diastolic blood pressure.</p>

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Immunological and biochemical markers in preeclampsia

Cited by 26 publications

References 18 publications

Preeclampsia in autologous and oocyte donation pregnancy: is there a different pathophysiology?

Preeclampsia in autologous and oocyte donation pregnancy: is there a different pathophysiology?

Vitamin D Status Is Related to Oxidative Stress But Not High-Sensitive C-Reactive Protein in Women with Pre-Eclampsia

Association of anticardiolipin IgM antibody with preeclampsia

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