Immunological and biochemical parameters of patients with metabolic syndrome and the participation of oxidative and nitroactive stress

Simão, Andréa Name Colado; Lozovoy, Marcell Alysson Batisti; Simão, Tathiana Name Colado; Venturini, Danielle; Barbosa, Décio Sabbatini; Dichi, Jane Bandeira; Matsuo, Tiemi; Cecchini, Rúbens; Dichi, Isaías

doi:10.1590/s0100-879x2011007500069

Cited by 16 publications

(4 citation statements)

References 31 publications

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“…This asymmetrical behavior might explain the lack of correlation between TBARS and NO x observed by us, differently from others, who found a positive correlation between hydroperoxide levels and NO x in MS [40]. In this regard, it must be considered that we evaluated a parameter of lipid peroxidation (TBARS) that includes not only hydroperoxides but also malondialdehyde.…”

Section: Discussionmentioning

confidence: 66%

Lipid Peroxidation, Nitric Oxide Metabolites, and Their Ratio in a Group of Subjects with Metabolic Syndrome

Caimi

Presti

Montana

et al. 2014

Oxidative Medicine and Cellular Longevity

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Our aim was to evaluate lipid peroxidation, expressed as thiobarbituric acid-reactive substances (TBARS), nitric oxide metabolites (nitrite + nitrate) expressed as NOx, and TBARS/NOx ratio in a group of subjects with metabolic syndrome (MS). In this regard we enrolled 106 subjects with MS defined according to the IDF criteria, subsequently subdivided into diabetic (DMS) and nondiabetic (NDMS) and also into subjects with a low triglycerides/HDL-cholesterol (TG/HDL-C) index or with a high TG/HDL-C index. In the entire group and in the four subgroups of MS subjects we found an increase in TBARS and NOx levels and a decrease in TBARS/NOx ratio in comparison with normal controls. Regarding all these parameters no statistical difference between DMS and NDMS was evident, but a significant increase in NOx was present in subjects with a high TG/HDL-C index in comparison with those with a low index. In MS subjects we also found a negative correlation between TBARS/NOx ratio and TG/HDL-C index. Considering the hyperactivity of the inducible NO synthase in MS, these data confirm the altered redox and inflammatory status that characterizes the MS and suggest a link between lipid peroxidation, inflammation, and insulin resistance, evaluated as TG/HDL-C index.

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Section: Discussionmentioning

confidence: 66%

Lipid Peroxidation, Nitric Oxide Metabolites, and Their Ratio in a Group of Subjects with Metabolic Syndrome

Caimi

Presti

Montana

et al. 2014

Oxidative Medicine and Cellular Longevity

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“…Patients diagnosed with MetS exhibit serum hallmarks of redox imbalance in the form of, e.g., increased levels of protein oxidation products, MDA, elevated XO activity, hyperglycemia (HG), elevated TG as well reduced concentrations of HDL-C, vitamin E and C along with declined levels of heat shock response proteins (HSP70) and SOD as compared to healthy probands [50][51][52]. Other studies indicated raised activity of erythrocyte-specific SOD and MPO with elevation of plasma concentrations of H2O2 and MDA in MetS patients in comparison to controls [53,54]. Moreover, a cross-sectional study conducted on the limited number of Japanese MetS patients and healthy subjects indicated an increase of systemic OxS, as determined by urinary 8-epiprostaglandin F2α (8-epi-PGF2α) in single urine samples, being correlated with visceral AT (VAT) accumulation [55].…”

Section: The Interplay Between Oxidative Stress and Metabolic Syndromementioning

confidence: 99%

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

Włodarski

Strycharz

Wróblewski

et al. 2020

IJMS

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Oxidative stress (OxS) is the cause and the consequence of metabolic syndrome (MetS), the incidence and economic burden of which is increasing each year. OxS triggers the dysregulation of signaling pathways associated with metabolism and epigenetics, including microRNAs, which are biomarkers of metabolic disorders. In this review, we aimed to summarize the current knowledge regarding the interplay between microRNAs and OxS in MetS and its components. We searched PubMed and Google Scholar to summarize the most relevant studies. Collected data suggested that different sources of OxS (e.g., hyperglycemia, insulin resistance (IR), hyperlipidemia, obesity, proinflammatory cytokines) change the expression of numerous microRNAs in organs involved in the regulation of glucose and lipid metabolism and endothelium. Dysregulated microRNAs either directly or indirectly affect the expression and/or activity of molecules of antioxidative signaling pathways (SIRT1, FOXOs, Keap1/Nrf2) along with effector enzymes (e.g., GPx-1, SOD1/2, HO-1), ROS producers (e.g., NOX4/5), as well as genes of numerous signaling pathways connected with inflammation, insulin sensitivity, and lipid metabolism, thus promoting the progression of metabolic imbalance. MicroRNAs appear to be important epigenetic modifiers in managing the delicate redox balance, mediating either pro- or antioxidant biological impacts. Summarizing, microRNAs may be promising therapeutic targets in ameliorating the repercussions of OxS in MetS.

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“…Specific biomarkers of lipid peroxidation were reported to be associated with the number of cigarettes smoked daily, with lipid peroxidation increasing with the number of cigarettes smoked [24]. Increased superoxide production that derived from smoking leads to the inactivation of nitric oxide, thus contributing to endothelial dysfunction and predisposing to the development of metabolic syndrome [25], [26]. Since membrane-associated NADPH oxidase is the primary physiological producer of reactive oxygen species, including superoxide [27], p22phox is the primary enzyme interface between environmental oxidants and host organism, the genetic susceptibility ascribable to this enzyme family is expected to be associated with different dose levels of exposed xebobiotics.…”

Section: Discussionmentioning

confidence: 99%

Smoking Dose Modifies the Association between C242T Polymorphism and Prevalence of Metabolic Syndrome in a Chinese Population

Ge¹,

Ding

Yu³

et al. 2012

PLoS ONE

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BackgroundThe C242T polymorphism of the CYBA gene that encodes p22phox, a component of NADPH oxidase, has been found to modulate superoxide production. Oxidase is a major source of the superoxide anion that contributes to individual components of metabolic syndrome. We examined the relationship of the C242T polymorphism with the prevalence of metabolic syndrome in a Chinese population, taking account of consumed cigarette amounts.Methodology/Principal FindingsIn 870 participants, we collected biomarkers related to metabolic syndrome and detailed history of smoking and genotyped the C242T polymorphisms. After adjustment for covariates, the CT/TT genotypes were associated with a lower risk of metabolic syndrome (P = 0.0008). The odds of having metabolic syndrome in the CT/TT participants were 0.439 (95%CI: 0.265, 0.726), while for CC participants the odds were 1.110 (95%CI: 0.904, 1.362). There was significant (P = 0.014) interaction between the C242T polymorphism and smoking status in relation to the prevalence of metabolic syndrome. For smokers who smoke no less than 25 pack-years, those with CT/TT genotypes had lower risk of metabolic syndrome as compared with CC polymorphism carriers (P = 0.015). In the multiple regression analysis, the CT/TT genotypes were significantly associated with lower serum concentration of triglycerides both in all subjects and smokers; furthermore, the CT/TT genotypes were also related to smaller waist circumference in smokers.ConclusionsOur study suggests that the C242T gene polymorphism is indeed related to the prevalence of metabolic syndrome and smoking dose might modify this association.

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Immunological and biochemical parameters of patients with metabolic syndrome and the participation of oxidative and nitroactive stress

Cited by 16 publications

References 31 publications

Lipid Peroxidation, Nitric Oxide Metabolites, and Their Ratio in a Group of Subjects with Metabolic Syndrome

Lipid Peroxidation, Nitric Oxide Metabolites, and Their Ratio in a Group of Subjects with Metabolic Syndrome

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

Smoking Dose Modifies the Association between C242T Polymorphism and Prevalence of Metabolic Syndrome in a Chinese Population

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