Immunological and oxidative stress biomarkers in Ankylosing Spondylitis patients with or without metabolic syndrome

Pishgahi, Alireza; Abolhasan, Rozita; Danaii, Shahla; Amanifar, Bahareh; Soltani‐Zangbar, Mohammad Sadegh; Zamani, Majid; Kamrani, Amin; Ghorbani, Farzaneh; Mehdizadeh, Amir; Kafil, Hossein Samadi; Jadidi‐Niaragh, Farhad; Yousefi, Bahman; Hajialiloo, Mehrzad; Yousefi, Mehdi

doi:10.1016/j.cyto.2020.155002

Cited by 36 publications

(22 citation statements)

References 62 publications

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“…Furthermore, the comorbidities present in group 2 patients cannot explain the absence of marked oxidative damage. Indeed, high levels of oxidative stress are often measured in patients with ankylosing spondylitis [29] or Lyme disease [30], these comorbidities being present in six of our patients. Additionally, fatigue that leads to physical deterioration is another important symptom that is observed in 90% of patients with post-polio syndrome, probably resulting from spine frontal horn motor neuron damage during acute poliovirus infection [31].…”

Section: Discussionmentioning

confidence: 83%

Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome

et al. 2020

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Background: In myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), altered membrane excitability often occurs in exercising muscles demonstrating muscle dysfunction regardless of any psychiatric disorder. Increased oxidative stress is also present in many ME/CFS patients and could affect the membrane excitability of resting muscles.Methods: Seventy-two patients were examined at rest, during an incremental cycling exercise and during a 10-min post-exercise recovery period. All patients had at least four criteria leading to a diagnosis of ME/CFS. To explore muscle membrane excitability, M-waves were recorded during exercise (rectus femoris (RF) muscle) and at rest (flexor digitorum longus (FDL) muscle). Two plasma markers of oxidative stress (thiobarbituric acid reactive substance (TBARS) and oxidation-reduction potential (ORP)) were measured. Plasma potassium (K + ) concentration was also measured at rest and at the end of exercise to explore K + outflow.Results: Thirty-nine patients had marked M-wave alterations in both the RF and FDL muscles during and after exercise while the resting values of plasma TBARS and ORP were increased and exercise-induced K + outflow was decreased. In contrast, 33 other patients with a diagnosis of ME/CFS had no M-wave alterations and had lower baseline levels of TBARS and ORP. M-wave changes were inversely proportional to TBARS and ORP levels. Conclusions:Resting muscles of ME/CFS patients have altered muscle membrane excitability. However, our data reveal heterogeneity in some major biomarkers in ME/CFS patients. Measurement of ORP may help to improve the diagnosis of ME/CFS.

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Section: Discussionmentioning

confidence: 83%

Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome

et al. 2020

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“…Six studies [3,5,8,19,23,30] were included to analyze the association between oxidative stress and disease activity because they evaluated oxidative stress markers in patients with different disease activity. All studies ascertained patients using the modified New York criteria except two studies [4,34]. One of them used the Assessment in Spondy-loArthritis international Society (ASAS) criteria [4], and the other confirmed patients according to X-ray, MRI, CT, and laboratory inspections [34].…”

Section: Resultsmentioning

confidence: 99%

“…All studies ascertained patients using the modified New York criteria except two studies [4,34]. One of them used the Assessment in Spondy-loArthritis international Society (ASAS) criteria [4], and the other confirmed patients according to X-ray, MRI, CT, and laboratory inspections [34]. Part of patients in nine studies had taken nonsteroidal anti-inflammatory agent (NSAID), and no included patients used biological agents such as TNF-α blockers.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, other specific organs and systems such as eyes, skin, kidneys, gastrointestinal tract, and cardiovascular system can be affected with the development of AS, resulting in decreased quality of life [2]. Although the etiology of AS is still unclear, it has been reported that oxidative stress may play an important role in the pathogenesis of AS [3,4].…”

Section: Introductionmentioning

confidence: 99%

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Oxidative and Anti-oxidative stress-linked biomarkers in Ankylosing Spondylitis: a systematic review and meta-analysis

Li¹,

Liu²,

Cui³

2020

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Objective. Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects the axial skeleton, leading to joint disability. Our study aims at investigating the change of oxidative and antioxidative stress linked biomarkers in AS. Methods. This systematic review and meta-analysis was performed following the Preferred Reporting Items of Systematic Reviews and Meta-Analyses (PRISMA) statement. PubMed, Web of Science, and Cochrane Library databases till May 2020 were searched. Only articles published in English were included. Two reviewers screened relevant studies, extracted data, and assessed the quality of included studies using the Newcastle-Ottawa scale independently. Either random or fixed effect model was adopted base on the heterogeneity testing by I 2 statistic. Standardized mean difference (SMD) and 95% confidence intervals (CI) of oxidative and antioxidative markers were calculated. p value <0.05 was considered statistically significant. Results. A total of 22 studies including 931 AS patients and 917 healthy controls met the selection criteria. Significantly increased levels of all oxidative stress markers except myeloperoxidase, and significantly decreased levels of total antioxidant status (SMD = −1:19, 95% CI-2.35 to-0.03, p = 0:044) and paraoxonase 1(SMD = −1:01, 95% CI-1.78 to-0.24, p = 0:010) in serum were observed in AS patients when compared with healthy controls. However, there were no significant differences of all oxidative and anti-oxidative stress biomarkers in erythrocytes. Additionally, the levels of malondialdehyde (SMD = 0:51, 95% CI 0.21 to 0.81, p = 0:001) and advanced oxidation protein products (SMD = 0:95, 95% CI 0.58 to 1.31, p < 0:001) in serum were significantly higher in active patients when compared with inactive AS patients. Conclusion. This meta-analysis demonstrated an overall increase of oxidative markers and decrease of antioxidative markers in AS, suggesting that oxidative stress may play an important role in the pathogenesis of AS.

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“…In general, increased numbers of oxidative stress biomarkers were observed in patients with AS and PsA [67]. There are numerous reports from the literature showing that oxidative stress has an important function in AS pathogenesis [3,68]. There are hypotheses stating that high ROS toxicity may be responsible for articular cartilage damage and bone loss in AS [69].…”

Section: Haptoglobin and Oxidative Stressmentioning

confidence: 99%

Haptoglobin and Its Related Protein, Zonulin—What Is Their Role in Spondyloarthropathy?

Chmielińska

Olesińska

Romanowska-Próchnicka

et al. 2021

JCM

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Haptoglobin (Hp) is an acute phase protein which supports the immune response and protects tissues from free radicals. Its concentration correlates with disease activity in spondyloarthropathies (SpAs). The Hp polymorphism determines the functional differences between Hp1 and Hp2 protein products. The role of the Hp polymorphism has been demonstrated in many diseases. In particular, the Hp 2-2 phenotype has been associated with the unfavorable course of some inflammatory and autoimmune disorders. Its potential role in modulating the immune system in SpA is still unknown. This article contains pathophysiological considerations on the potential relationship between Hp, its polymorphism and SpA.

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Immunological and oxidative stress biomarkers in Ankylosing Spondylitis patients with or without metabolic syndrome

Cited by 36 publications

References 62 publications

Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome

Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome

Oxidative and Anti-oxidative stress-linked biomarkers in Ankylosing Spondylitis: a systematic review and meta-analysis

Haptoglobin and Its Related Protein, Zonulin—What Is Their Role in Spondyloarthropathy?

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