Immunological and respiratory findings in swine farmers

Zuśkin, E; Kanceljak, B; Schachter, E. Neil; Mustajbegović, Jadranka; Goswami, Satindra; Maayani, Saul; Marom, Zvi; Rienzi, N

doi:10.1016/s0013-9351(05)80002-7

Cited by 21 publications

(8 citation statements)

References 16 publications

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“…The data illustrated by these studies are similar to those of our previous studies with different organic dust extracts such as coffee, soy, spices, animal food, poultry and swine confinement building dust, brewery dust (hops, barley, yeast), as well as textile dust (cotton, hemp and wool) [23][24][25][35][36][37][38][39][40][41][42]. The pharamcologic studies of paper dust extract on isoalted guinea pig tracheal smooth muscle suggest a complex effect of this airway irritant.…”

Section: Discussionsupporting

confidence: 82%

Effects of Recycled Paper Dust Extracts on Isolated Guinea Pig Trachea

Schachter

Zuśkin

Rienzi

et al. 1998

Lung

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The effect of paper dust collected at two different locations in a paper recycling plant (PD1 and PD2) on isolated nonsensitized guinea pig tracheal smooth muscle was studied in vitro. Dust extracts were prepared as a 1:10 w/v aqueous solution. Dose-related contractions of guinea pig tracheal rings were elicited with both PD1 and PD2. Pharmacologic studies were performed with atropine (10(-6) M), indometacin (10(-6) M), pyrilamine (10(-6) M), LY171883 (10(-5) M), nordihydroguaiaretic acid (10(-5) M), and TMB8 (10(-5) M). The possible role of endogenous neuropeptides in this constrictor process was studied by depleting neural mediators with capsaicin (5 x 10(-6) M) before challenge with dust extracts. Constrictor effects were partially inhibited by a wide variety of the mediator blocking agents. The effects of both extracts were almost totally inhibited by the anticholinergic agent atropine, suggesting that a principal pathway mediating this response may involve the parasympathetic nervous system. The intracellular calcium-blocking agent TMB8 also induced a reduction of the contractile responses to PD1 and PD2 consistent with the well established role of intracellular calcium in smooth muscle constriction. Pretreatment with capsaicin significantly increased the contractile activity of paper dust extracts but only at the higher doses of these extracts. This suggests that the effect of paper dust is not initiated by the release of mediators stored in sensory nerves but that the prerelease of these mediators may enhance the constrictor effects of these dusts. We suggest that paper dust extracts cause dose-related airway smooth muscle constriction possibly associated with the release of cholinergic as well as other mediators. The constrictor effect does not require tissue presensitization or the release of neuropeptides from sensory nerves.

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Section: Discussionsupporting

confidence: 82%

Effects of Recycled Paper Dust Extracts on Isolated Guinea Pig Trachea

Schachter

Zuśkin

Rienzi

et al. 1998

Lung

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“…Since that time, numerous epidemiological studies have been conducted in the United States, Canada, and Western Europe, documenting this occupational hazard [Donham et al, 1982[Donham et al, , 1984a[Donham et al, ,b, 1989Attwood, 1987;Cormier, 1991;Bongers, 1987;Haglind, 1987;Holness, 1987;Dosman, 1988;Zuskin, 1991;Wilhelmsson, 19891. Several review articles have been published summarizing these epidemiological and environmental findings [Donham, 1990[Donham, , 1992[Donham, , 1993Rylander, 19891. Although there have been many studies documenting the widespread nature of the hazard, there have been only a few articles published regarding prevention.…”

Section: Introductionmentioning

confidence: 99%

Respiratory dysfunction in swine production facility workers: Dose‐response relationships of environmental exposures and pulmonary function

Donham

Reynolds

Whitten

et al. 1995

American J Industrial Med

195

153

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Human respiratory health hazards for people working in livestock confinement buildings have been recognized since 1974. However, before comprehensive control programs can be implemented, more knowledge is needed of specific hazardous substances present in the air of these buildings, and at what concentrations they are harmful. Therefore, a medical epidemiological and exposure-response study was conducted on 207 swine producers using intensive housing systems (108 farms). Dose-response relationships between pulmonary function and exposures are reported here. Positive correlations were seen between change in pulmonary function over a work period and exposure to total dust, respirable dust, ammonia, respirable endotoxin, and the interactions of age-of-producer and dust exposure and years-of-working-in-the-facility and dust exposure. Relationships between baseline pulmonary function and exposures were not strong and therefore, not pursued in this study. The correlations between exposure and response were stronger after 6 years of exposure. Multiple regression models were used to identify total dust and ammonia as the two primary environmental predictors of pulmonary function decrements over a work period. The regression models were then used to determine exposure concentrations related to pulmonary function decrements suggestive of a health hazard. Total dust concentrations > or = 2.8 mg/m3 were predictive of a work period decrement of > or = 10% in FEV1. Ammonia concentrations of > or = 7.5 ppm were predictive of a > or = 3% work period decrement in FEV1. These predictive concentrations were similar to a previous dose-response study, which suggested 2.5 mg/m3 of total dust and 7 ppm of NH3 were associated with significant work period decrements. Therefore, dust > or = 2.8 mg/m3 and ammonia > or = 7.5 ppm should be considered reasonable evidence for guidelines regarding hazardous exposure concentrations in this work environment.

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“…[8][9][10] The role of airborne exposure to pig urinary proteins (PUP) and of anti-PUP IgE sensitization in respiratory health problems of pig farmers are, however, not completely understood. Incidental cases have been described of occupational asthma associated with IgE anti-PUP antibodies, [11][12][13] but studies in which atopic anti-PUP sensitization has been systematically investigated in populations, 12,[14][15][16][17][18][19] have produced largely different prevalences of positive skin prick tests (SPT) or IgE serology, from (nearly) complete absence 14,18,19 up to 12%, 6 18% 18 and even 44%, 15 while the associations with presence of respiratory symptoms or other respiratory disease indices were not always clear. Moreover, in the studies showing a high prevalence of pig-specific SPT or IgE reactions, 15,18 positive test results were also found with relatively high frequencies--39% and 10%, respectively--in controls with neither occuptional exposure nor respiratory disease.…”

Section: Introductionmentioning

confidence: 99%