-The purpose of this study was to investigate the influences of immune function and respiratory system on aerobic exercise of 75 %HRmax intensity in an exposed acute hypobaric hypoxic environment. The subjects were 20 male college students, 10 of which were soccer players (19.6±0.8 yr, BMI 22.3±1.0, VO2max 56.5±4.8 ml/kg/min) and 10 general students (22.2±2.3 yr, BMI 22.7±2.1, VO2max 50.5±6.6 ml/kg/min). Items of measurement after exercise on level and high altitude were O2, CO2, ventilation (VE), respiratory frequency, respiratory quotient, RBC, MCV, MCH, MCHC, Hb, Hct, reticulocyte, WBC, neutrophil, lymphocyte, monocyte, basophil, and immunoglobulin (IgA, IgD, IgG, IgM). As the result of the verifying hypothesis, these results may suggest three new findings: first, to produce hypoxic ventilatory depression not only at level land but also at 3,000 m high altitude during 30 minute aerobics exercise of 75 %HRmax intensity, second to be more excellent for soccer players in adaptation and sensibility on response of respiratory system at high altitude, and third, to change each other by regular exercise habits or altitude in the monocyte. 우리나라 연구진에 의한 고지환경 및 고지시뮬레이션(저 압·저산소환경, 산소분압 조절장치)에서의 적응능력과 관련 된 선행연구는 다수 보고된 바가 있다 [9][10][11]14,15,23,31].구체적으로, 일정기간의 고지 트레이닝의 적응 후 생체적 응 반응으로써는 평지에서의 산소운반 능력 증가(적혈구수 및 헤모글로빈농도의 증가, 근육마이오글로빈 중가, 미토콘 드리아 관련 효소활성도 증가)를 통해 심폐기능의 향상을 가 져오며 [4,5,12,25,17]