Immunological Aspects of Systemic Vasculitis

Ahmed, Mélika Ben; Louzir, Hechmi

doi:10.1007/174_2011_144

Cited by 3 publications

(1 citation statement)

References 145 publications

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“…These processes primarily involve T-lymphocyte immune response and hypersensitivity reactions characterized by formation of antigen-antibody-complement complexes with neutrophil recruitment. 33,34 The resulting immunological reactions contribute to overall weakening of vessel walls, which promote VAA formation when medium-sized vessels are implicated. Polyarteritis nodosa (PAN) is an example of a fibrinoid necrotizing vasculitis involving both small-and medium-sized arteries that can also present with aneurysms up to 1 cm in diameter within the mesenteric, hepatic, and/or splenic arteries.…”

Section: Noninfectious Processesmentioning

confidence: 99%

Visceral Artery Aneurysms and Pseudoaneurysms: Etiology, Diagnosis, and Endovascular Management

Kapoor

Karuppasamy

2018

Dig Dis Interv

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Visceral artery aneurysms (VAAs) are rare entities arising from several locations in the mesenteric vasculature. The etiology, clinical presentation, and subsequent management of these aneurysms vary widely. Although true aneurysms and pseudoaneurysms can present similarly on imaging, by definition they are distinct in their structural composition and hence may require tailored interventional planning. Treatment conventionally involves open surgery, endovascular intervention or careful observation. Recently, endovascular approaches have shown increasing popularity given the higher success rates and shorter lengths of stay with these procedures versus surgery. Optimal endovascular treatment planning is determined by the interventionalist based on unique features of each aneurysm and underlying vascular anatomy. This article reviews the etiology, diagnosis, and endovascular management for VAAs and pseudoaneurysms.

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Section: Noninfectious Processesmentioning

confidence: 99%

Visceral Artery Aneurysms and Pseudoaneurysms: Etiology, Diagnosis, and Endovascular Management

Kapoor

Karuppasamy

2018

Dig Dis Interv

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Development of an Experimental Model of Vasculitis Using Ovalbumin Lipopolysaccharide in Rats

Thakur,

Mehta

2024

Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci.

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The Use of Next-Generation Sequencing to Assist in the Diagnosis of Atypical Vasculitis

Chetrit,

Aung,

Cheng

et al. 2024

Cureus

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Vasculitis can be challenging to diagnose, especially when vessels of multiple sizes are affected and manifestations do not classically fit into defined rheumatic disease entities. We present the case of a 58-year-old Caucasian woman who presented with headache and altered mental status, with subsequent left-sided hemiparesis and hemispatial neglect eight days after a dental procedure. She was found to have extensive multi-focal ischemic infarctions secondary to vasculitis affecting multiple intracranial blood vessels. Subsequent imaging showed increasing involvement of intra-abdominal blood vessels. There was no evidence of endocarditis. Serologies for lupus and autoimmune rheumatologic diseases were unremarkable. Our suspicion was high for an infectious trigger of vasculitis. However, extensive conventional diagnostic testing, including multiple blood cultures and brain biopsy, did not reveal an underlying infectious etiology. The use of next-generation sequencing (NGS) of cell-free DNA from blood revealed the infectious pathogen Prevotella melaninogenica . Combining targeted anti-microbials with systemic steroids, plasmapheresis, and immune suppressant therapy, this case had a favorable outcome. The use of NGS can be useful in the diagnosis of atypical vasculitis.

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Immunological Aspects of Systemic Vasculitis

Cited by 3 publications

References 145 publications

Visceral Artery Aneurysms and Pseudoaneurysms: Etiology, Diagnosis, and Endovascular Management

Visceral Artery Aneurysms and Pseudoaneurysms: Etiology, Diagnosis, and Endovascular Management

Development of an Experimental Model of Vasculitis Using Ovalbumin Lipopolysaccharide in Rats

The Use of Next-Generation Sequencing to Assist in the Diagnosis of Atypical Vasculitis

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