Immunological consequences of the reversal of social status in C57BL/6J mice

Devoino, L. V.; Альперина, Е. Л.; Pavina, T. A.

doi:10.1016/s0889-1591(02)00037-5

Cited by 26 publications

(18 citation statements)

References 25 publications

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“…Corroborating this hypothesis, Cohen et al (1997) observed that primates with higher levels of aggressive behavior presented lower susceptibility to respiratory infection. In the same way, Devoino et al (2003) observed that the occurrence of aggressive behavior in previously submissive rats produced immune stimulation.…”

Section: Discussionmentioning

confidence: 67%

The expression of an intraspecific aggressive reaction in the face of a stressor agent alters the immune response in rats

et al. 2005

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The repercussion on the immune response of the expression of intraspecific aggressiveness in the face of a stressor agent was investigated in rats. Ninety-day-old animals were divided into three groups: the control group (only immunological measurements were performed), the foot-shock (FS) (animals individually receiving FS), and the intraspecific aggressive response (IAR) group (animals receiving FS and presenting IAR). For immunological measurements, blood samples were collected promptly at 7 and 15 days after FS or IAR. The FS reduced the total leukocyte amount presented. However, aggressiveness triggered not only reduction of the leukocytes, but also lymphocyte decrease and neutrophil increase. Moreover, an elevation in total leukocytes associated with an increase in the humoral immune response was also observed one week after IAR. In this study, the expression of intraspecific aggressiveness in the face of a stressor seemed to activate the immune system and to potentiate the antigen specific humoral response.Key words: intraspecific aggressiveness, leukocytes, humoral immune response. RESUMOA expressão de uma reação agressiva intra-específica diante de um estressor altera a resposta imune em ratos A repercussão sobre a resposta imune da expressão da agressividade intra-específica diante de um estressor foi investigada em ratos. Aos 90 dias de vida, os animais foram divididos em três grupos: grupo-controle (foram realizadas apenas mensurações imunológicas), choque nas patas (FS) (os animais receberam FS individualmente) e grupo resposta agressiva intra-específica (IAR) (os animais receberam FS e apresentaram IAR). Para as medições imunológicas, amostras de sangue foram coletadas imediatamente, 7 e 15 dias após FS ou IAR. O FS reduziu a quantidade total de leucócitos. Contudo, a agressividade foi acompanhada, além da redução do número de leucócitos, por diminuição de linfócitos e aumento de neutrófilos. Além disso, também foi observada elevação no número de leucócitos associada a aumento na resposta imune humoral uma semana após as IAR. Neste estudo, a expressão da agressividade intra-específica diante de um estressor parece ativar o sistema imune e potencializar a resposta humoral antígeno específica.Palavras-chave: agressividade intra-específica, leucócitos, resposta imune humoral.

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Section: Discussionmentioning

confidence: 67%

The expression of an intraspecific aggressive reaction in the face of a stressor agent alters the immune response in rats

et al. 2005

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“…These stress-induced effects are not inconsequential; high stress reactivity has been linked to increased susceptibility to infection and immune dysfunction (Black, 2002;Padgett and Glaser, 2003;Glaser and Kiecolt-Glaser, 1998;Kiecolt-Glaser et al, 2002;Liu et al, 2002;Rohleder et al, 2001;Cohen and Hamrick, 2003). Some of these effects can be modeled on the laboratory, and as we and others have shown, social defeat activates the core stress responses and can have deleterious immunological effects on defeated mice (Devoino et al, 2003;Merlot et al, 2003;Padgett et al, 1998;Sheridan et al, 2000), including increased proinflammatory cytokine production, splenomegaly, trafficking of lymphocytes to the spleen, and insensitivity to the antiproliferative effects of glucocorticoids in LPS-stimulated splenocytes (Avitsur et al, 2003;Bailey et al, 2006;Engler et al, 2005;Stark et al, 2001). Although slight differences occurred between C57BL/6 mice and CD-1 mice, the present data indicate that the development of anxiety-like behavior can be added to the list of consequences mediated by social disruption.…”

Section: Discussionmentioning

confidence: 99%

Repeated social defeat causes increased anxiety-like behavior and alters splenocyte function in C57BL/6 and CD-1 mice

Kinsey

Bailey

Sheridan

et al. 2007

Brain, Behavior, and Immunity

167

133

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The experimental model, social disruption (SDR), is a model of social stress in which mice are repeatedly attacked and defeated in their home cage by an aggressive conspecific. In terms of the impact of this stressor on the immune response, SDR has been reported to cause hyperinflammation and glucocorticoid insensitivity. To this point however, the behavioral consequences of SDR have not been thoroughly characterized. Because social defeat has been reported to cause anxiety-and depressive-like behaviors, the current study was designed to assess whether SDR also causes anxietyand depressive-like behaviors. Using the light/dark preference test and the open field test as tools to measure behaviors characteristic of anxiety, the data showed that C57BL/6 and CD-1 male mice subjected to SDR displayed increased anxiety-like behavior. The increase in anxiety-like behaviors persisted for at least one week after the cessation of the stressor. In contrast, depressive-like behaviors were not elicited by SDR as assessed by the forced swim test or the tail suspension test. These data indicate that social disruption stress causes an increase in anxiety-like behaviors, but not depressivelike behaviors.

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“…It has been shown that lowaggressive ("passive" strategy) wild house mice have faster thymus involution under defeat stress (Veenema et al, 2004). Moreover, acute stress induces immune stimulation in "aggressive" and immunosuppression in "submissive" C57Bl/6J mice (Devoino et al, 2003).…”

Section: Animal Studiesmentioning

confidence: 99%

“…These styles are distinguished as flight/fight, repressive/defensive, submissive/aggressive, anger-in/anger-out, blunting/monitoring, negative/positive, etc. (Jamner at al., 1988;De Boer et al, 1990;Zozulya et al, 1996;Devoino et al, 2003;Veenema et al, 2004). In general, coping styles might be grouped into "passive" and "active" patterns.…”

mentioning

confidence: 99%