Immunological differences in the global release of the major cat allergen Fel d 1 are influenced by sex and behaviour

Bienboire-Frosini, Cécile; Cozzi, Alessandro; Lafont-Lecuelle, Céline; Vervloët, D.; Ronin, Catherine; Pageat, Patrick

doi:10.1016/j.tvjl.2011.09.031

Cited by 19 publications

(31 citation statements)

References 28 publications

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“…8,17 Natural variation of allergen from biological sources was reported for birch pollen, 19 olive pollen, 20 horses, 21 and cats. 22 Allergen release also varies during the lifespan of pollen. 23 Monitoring allergens in ambient air enables the detection of non-pollen-bound allergens, as encountered during special weather conditions, such as thunderstorms.…”

mentioning

confidence: 99%

Variation of the group 5 grass pollen allergen content of airborne pollen in relation to geographic location and time in season

Buters

Prank

Sofiev

et al. 2015

Journal of Allergy and Clinical Immunology

165

107

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mentioning

confidence: 99%

Variation of the group 5 grass pollen allergen content of airborne pollen in relation to geographic location and time in season

Buters

Prank

Sofiev

et al. 2015

Journal of Allergy and Clinical Immunology

165

107

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“…Secretions from anal glands have a distinctive odor and are released by frightened cats, possibly as a communication tool. Cats that are "handling-avoidant" and present aggressive behaviors have a greater release of Fel d 1 compared to those presenting a shy and/or friendly behavior, suggesting that aggressive cats may express their anal sacs during unwanted handling [19].…”

Section: Cat Allergensmentioning

confidence: 99%

“…This production varies not only between cats but also within the same cat, throughout the span of one day and/or between multiple days. Moreover, it is also influenced by the cats' sex [19,20]. Male cats produce greater amounts of the allergen than females, as sebum production is directly dependent on androgens, mainly testosterone.…”

Section: Cat Allergensmentioning

confidence: 99%

An overview of the effect of diet on the allergenicity of cats to susceptible humans

Aldrich¹,

Pezzali²,

Smith³

2018

SOJVS

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Relationships between humans and their pets have evolved to the point that pets are considered members of the family. Cats are one of the most popular pets worldwide, but many people suffer from allergies to pet dander. As a result, allergies are the second leading cause for cat relinquishment. Cat dander consists of a variety of immunoglobulin proteins, the most prominent of which is Fel d 1. This allergen accounts for 60-90% of total allergenicity. The majority of production of this protein occurs in the sebaceous glands of the animal. It is transferred to the skin through the sebum, where it accumulates in the fur and can then be released into the environment. When inhaled by humans, Fel d 1 can induce an allergic response in susceptible individuals. Due to the complexity of this allergen, a completely effective treatment has yet to be developed. Therefore, methods to reduce the production and release of Fel d 1 in the cat should be explored. Sebum production is under regulation of many hormones and mediators, and nutritional compounds may act as inhibitors in some pathways. By inhibiting certain points in these pathways with nutritional compounds such as polyphenols, carotenoids, fatty acids, and a decreased glycemic index diet, it may be possible to decrease production of Fel d 1 in cats. With a lower release of the allergen and adequate cleaning management, there is a high probability based on the current hypothesis to lower its concentration in the environment and consequently, decrease the symptoms in allergic people.

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“…One function for the box would be to hold a species-specific message, and the varying compositions of the α/β chains in different species support this idea [23]. Cats heavily contaminate their environments with Fel-d1, using the protein not as a toxic defence, but as a species recognition molecule [24]. What evidence is there that loris toxin has a function in nature or in experimental settings?…”

Section: Reviewmentioning

confidence: 99%

Mad, bad and dangerous to know: the biochemistry, ecology and evolution of slow loris venom

Nekaris

Moore

Rode

et al. 2013

J Venom Anim Toxins incl Trop Dis

172

137

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Only seven types of mammals are known to be venomous, including slow lorises (Nycticebus spp.). Despite the evolutionary significance of this unique adaptation amongst Nycticebus, the structure and function of slow loris venom is only just beginning to be understood. Here we review what is known about the chemical structure of slow loris venom. Research on a handful of captive samples from three of eight slow loris species reveals that the protein within slow loris venom resembles the disulphide-bridged heterodimeric structure of Fel-d1, more commonly known as cat allergen. In a comparison of N. pygmaeus and N. coucang, 212 and 68 compounds were found, respectively. Venom is activated by combining the oil from the brachial arm gland with saliva, and can cause death in small mammals and anaphylactic shock and death in humans. We examine four hypotheses for the function of slow loris venom. The least evidence is found for the hypothesis that loris venom evolved to kill prey. Although the venom’s primary function in nature seems to be as a defense against parasites and conspecifics, it may also serve to thwart olfactory-orientated predators. Combined with numerous other serpentine features of slow lorises, including extra vertebra in the spine leading to snake-like movement, serpentine aggressive vocalisations, a long dark dorsal stripe and the venom itself, we propose that venom may have evolved to mimic cobras (Naja sp.). During the Miocene when both slow lorises and cobras migrated throughout Southeast Asia, the evolution of venom may have been an adaptive strategy against predators used by slow lorises as a form of Müllerian mimicry with spectacled cobras.

show abstract

Immunological differences in the global release of the major cat allergen Fel d 1 are influenced by sex and behaviour

Cited by 19 publications

References 28 publications

Variation of the group 5 grass pollen allergen content of airborne pollen in relation to geographic location and time in season

Variation of the group 5 grass pollen allergen content of airborne pollen in relation to geographic location and time in season

An overview of the effect of diet on the allergenicity of cats to susceptible humans

Mad, bad and dangerous to know: the biochemistry, ecology and evolution of slow loris venom

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