Immunological effect of local ablation combined with immunotherapy on solid malignancies

Takahashi, Yusuke; Matsutani, Noriyuki; Nakayama, Takashi; Dejima, Hitoshi; Uehara, Hirofumi; Kawamura, Masafumi

doi:10.1186/s40880-017-0216-5

Cited by 23 publications

(19 citation statements)

References 95 publications

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“…There is an increasing body of evidence that RFA could stimulate transient distant immune response. Combining this response with immunotherapy may stimulate enhanced antitumor activity 10,13,35,36 . However, most studies focused on the tumor of RFA side to understand the changes in the TME.…”

Section: Discussionmentioning

confidence: 99%

High-dimensional single-cell analysis delineates radiofrequency ablation induced immune microenvironmental remodeling in pancreatic cancer

et al. 2020

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Radiofrequency ablation (RFA) is an effective local therapy approach for treating solitary tumor of many types of malignancy. The impact of RFA on the tumor immune microenvironment on distant tumors after RFA treatment is still unclear. In this study, by using syngeneic tumor models and single-cell RNA and T-cell receptor sequencing, we have investigated the alterations of tumor-infiltrating immune cells in distant non-RFA tumors. Single-cell RNA sequencing identified six distinct lymphoid clusters, five distinct monocyte/macrophage clusters, three dendritic cells clusters, and one cluster of neutrophils. We found that RFA treatment reduced the proportions of immunosuppressive cells including regulatory T cells, tumorassociated macrophages and tumor-associated neutrophils, whereas increased the percentages of functional T cells in distant non-RFA tumors. Moreover, RFA treatment also altered gene expressions in single-cell level in each cell cluster. By using pseudo-time analysis, we have described the biological processes of tumor-infiltrating CD8 + T cells and monocytes/ macrophages based on the transcriptional profiles. In addition, the immune checkpoints including PD-1 and LAG3 were upregulated in the T cells in distant non-RFA tumors after RFA treatment. In conclusion, our data indicate that RFA treatment induced remodeling of tumor immune microenvironment in distant non-RFA tumors in pancreatic cancer mouse model and suggest that combining RFA with immune checkpoint inhibitors may be an effective treatment approach.

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Section: Discussionmentioning

confidence: 99%

High-dimensional single-cell analysis delineates radiofrequency ablation induced immune microenvironmental remodeling in pancreatic cancer

et al. 2020

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“…Moreover, uniting local ablation and immunotherapies such as PD-1 inhibitors is one of the most potent regimens that oncologists can manipulate. One vital weakness of PD-1 blockers is their inability to penetrate the cancer microenvironment in cold tumors [ 134 ], which can be gained with the assistance of local ablation [ 135 ]. Hence, this combination will potentiate the effectiveness of both treatments, especially in solid tumors [ 136 ].…”

Section: Potential Strategies For Improving the Efficacy Of Pd-1/lmentioning

confidence: 99%

Current and Future Perspectives of PD-1/PDL-1 Blockade in Cancer Immunotherapy

Makuku

Khalili

Razi

et al. 2021

Journal of Immunology Research

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Cancer immunotherapy, which reactivates weakened immune cells of cancer patients, has yielded great success in recent years. Among immunotherapeutic agents, immune checkpoint inhibitors have been of particular interest and have gained approval by the FDA for treatment of cancers. Immune checkpoint blockade through targeting programmed cell death protein-1 (PD-1) has demonstrated promising antitumor effects in cancer immunotherapy of many different solid and hematologic malignancies. However, despite promising results, a favorable response is observed only in a fraction of patients, and there is still lack of a single therapy modality with curative ability. In this paper, we review the current and future perspectives of PD-1/L1 blockade in cancer immunotherapy, with a particular focus on predictive biomarkers of response to therapy. We also discuss the adverse events associated with PD-1/L1/2 inhibitors, ranging from severe life-threatening conditions such as autoimmune myocarditis to mild and moderate reactions such as skin rashes, and explore the potential strategies for improving the efficacy of immunotherapy with PD-1/L1 checkpoint inhibitors.

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“…Tumor is still a changing problem in our clinical work and many studies attempt to explore different methods to deal with it. Recently, combining several immunotherapeutic trials on treating solid tumor have achieved successful results, but they still need more practice [ 38 ]. Although the researches of chemical synthesized nano-carriers are much more than platelet drug-loaded system, there are various problems in the literature report on the nano-carriers.…”

Section: Resultsmentioning

confidence: 99%

Platelet-inspired medicine for tumor therapy

Yang

Wang²,

Liu

et al. 2017

Oncotarget

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As the number of patients with tumor increases dramatically recent years, traditional therapies expose more and more problems which can even lead to death. Many researchers and clinicians quest for an efficient drug delivery system to deal with tumor as a result. With the researches further develop, we find that platelet can interact with tumor cells through a variety of ways. So it can be used as a carrier broadly to deliver different anti-tumor drugs for tumor treatment. In the present review, we summarize the interaction of tumor cells and platelet. At the same time, we focus on recent progress on the application of platelet drug-loaded system in the anti-tumor prospects.

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Immunological effect of local ablation combined with immunotherapy on solid malignancies

Cited by 23 publications

References 95 publications

High-dimensional single-cell analysis delineates radiofrequency ablation induced immune microenvironmental remodeling in pancreatic cancer

High-dimensional single-cell analysis delineates radiofrequency ablation induced immune microenvironmental remodeling in pancreatic cancer

Current and Future Perspectives of PD-1/PDL-1 Blockade in Cancer Immunotherapy

Platelet-inspired medicine for tumor therapy

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