Immunological Evidence of Uteroglobin (Blastokinin) in the Male Reproductive Tract and in Nonreproductive Ductal Tissues and Their Secretions

Noske, Ingrid G.; Feigelson, Muriel

doi:10.1095/biolreprod15.5.704

Cited by 60 publications

(23 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence in the lung extract of a protein antigenically related to uteroglobin has already been reported (Noske & Feigelson, 1976;Daniel & Milazzo, 1976;Beier, 1977;Bullock, 1977). Noske & Feigelson (1976) (Beier, 1968;Mayol & Longenecker, 1974;Noske & Feigelson, 1976).…”

Section: Discussionmentioning

confidence: 83%

“…If we therefore assume that the uteroglobin-like protein is synthesized in the lung, the question arises as to the regulation of its synthesis. Whereas in the endometrium uteroglobin is induced by progesterone, in the oviduct by oestrogens and in the male genital tract probably by androgens (for a review see Beato, 1977), the synthesis of uteroglobin in the lung appears to be independent of the hormonal status of male or female animals (Noske & Feigelson, 1976) and the protein is already present in the fetal lung (Daniel & Milazzo, 1976). The independence of lung 'uteroglobin' synthesis from gonadal hormones might simply reflect the absence of the corresponding hormone receptor, but the mechanism of the differential regulation of uteroglobin biosynthesis in various tissues offers interesting possibilities for the study of gene expression in eukaryotes.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies with refined immunological techniques have demonstrated the presence of uteroglobin-like antigens in other organs of the rabbit, e.g. the oviduct, the male genital tract, the digestive tract, and the respiratory tract (Kay & Feigelson, 1972 ; Petzoldt, Dames, Gottschewski & Neuhoff, 1972 ; Goswami & Feigelson, 1974 ;Beier, Bohn & Müller, 1975 ; Kirchner, 1976 ; Noske & Feigelson, 1976 ; Daniel & Milazzo, 1976;Kirchner & Schroer, 1976;Bullock, 1977;Beier, 1977).…”

Section: Introductionmentioning

confidence: 99%

“…Endometrial uteroglobin can be induced by progesterone ad¬ ministration, which leads to an accumulation of the mRNA for a precursor of the uteroglobin monomer in the endometrial polysomes (Beier, 1968;Beier, Petry & Kiihnel, 1970;Bullock & Willen, 1974;Mayol & Longenecker, 1974;Beato & Arnemann, 1975;Beato & Rungger, 1975;Bullock et al, 1976;Levey & Daniel, 1976). In the oviduct, the uteroglobinlike protein is induced by oestrogens (Kay & Feigelson, 1972;Goswami & Feigelson, 1974), and in the lung its presence appears to be independent of ovarian steroids (Noske & Feigelson, 1976). It seems relevant, therefore, to ask whether the uteroglobin-like antigen present in the lung is identical to uteroglobin in structure and function.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Characteristics of the purified uteroglobin-like protein from rabbit lung

Beato¹,

Beier²

1978

Reproduction

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Characteristics of the purified uteroglobin-like protein from rabbit lung

Beato¹,

Beier²

1978

Reproduction

View full text Add to dashboard Cite

“…3 and 4). Later, the protein was also found in the oviduct (5), the male genital tract (6), and the lung (7). Although its general physiological role remains unclear, in the rabbit uterus the protein might be involved in implantation of the trophoblast and/or in anti-inflammatory reactions (4,8,9).…”

mentioning

confidence: 99%

Hormone-dependent Recruitment of NF-Y to the Uteroglobin Gene Enhancer Associated with Chromatin Remodeling in Rabbit Endometrial Epithelium

Scholz

Truss

Beato

1999

Journal of Biological Chemistry

View full text Add to dashboard Cite

Expression of the rabbit uteroglobin gene is hormonally induced in cells of the endometrial epithelium during the preimplantation phase of pregnancy. Here we show that progesterone activation of the gene is mediated by two clusters of hormone responsive elements located between 2.4 and 2.7 kilobase pairs upstream of the transcriptional start site. Between these two clusters, genomic footprinting studies in the intact endometrial epithelium reveal the hormone-inducible occupancy of several cis-acting elements. One of the protected elements shows sequence homology to the consensus binding site of the transcription factor NF-Y, which binds to the element in gel shift experiments. This uteroglobin Y box is essential for enhancer activity in transient transfection experiments with endometrial and non-endometrial cell lines, in accordance with the ubiquitous expression of NF-Y. To understand why binding of this ubiquitous factor to the uteroglobin Y box in endometrium depends on hormone induction, we examined the chromatin structure of the relevant gene region. In the uninduced state, the enhancer region appears to be organized into positioned nucleosomes. Upon hormone induction, this nucleosomal pattern is lost and the enhancer region becomes hypersensitive to nucleases, suggesting that a hormone-induced change in the local chromatin structure unmasks previously unaccessible binding sites for transcription factors. Our results emphasize the limitations of using transient transfection assays for the functional analysis of cis-acting elements and underline the need for including the native chromatin organization in this kind of studies.

show abstract

Selective sequestration of an oviductal fluid glycoprotein in the perivitelline space of mouse oocytes and embryos

1986

View full text Add to dashboard Cite

Previously, we identified a 215 kd glycoprotein, GP215, which is associated with postovulatory oocytes and embryos, but not with preovulatory oocytes (Kapur and Johnson, '85). In this paper a polyclonal antibody that specifically recognizes GP215 has been used to study the distribution of the molecule in association with ova and preimplantation embryos and in the female reproductive tract. GP215 is present in epithelial cells lining the cranial portions of the oviduct and in oviductal fluid, ovarian bursal fluid, and medium conditioned by oviductal tissue in vitro. Immunofluorescence assays of the ovum and early embryo show that GP215 is sequestered in the perivitelline space. Since preovulatory oocytes exposed to bursal fluid in vitro acquire GP215, we hypothesize that GP215 is synthesized and secreted by the oviductal epithelium and secondarily associates with the ovulated oocyte. Sequestration of GP215 within the perivitelline space is relatively specific since mouse serum albumin, a major constituent of oviductal fluid, and other high molecular weight proteins are not similarly retained. These observations indicate that the composition of the perivitelline space may be significantly different from the greater environment external to the zona pellucida such that fertilization and early development of mammalian ova potentially take place in a distinct perivitelline microenvironment.

show abstract

Immunological Evidence of Uteroglobin (Blastokinin) in the Male Reproductive Tract and in Nonreproductive Ductal Tissues and Their Secretions

Cited by 60 publications

References 28 publications

Characteristics of the purified uteroglobin-like protein from rabbit lung

Characteristics of the purified uteroglobin-like protein from rabbit lung

Hormone-dependent Recruitment of NF-Y to the Uteroglobin Gene Enhancer Associated with Chromatin Remodeling in Rabbit Endometrial Epithelium

Selective sequestration of an oviductal fluid glycoprotein in the perivitelline space of mouse oocytes and embryos

Contact Info

Product

Resources

About