Immunological Facilitation, a Broadening of the Concept of the Enhancement Phenomenon

Ga, Voisin

doi:10.1159/000392429

Cited by 46 publications

(43 citation statements)

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“…The phenomenon of passive enhancement of tumor and tissue allografts (1,5) has been shown to be associated with only minimal alteration in cellular immune responsiveness in the host (6). In contrast, immunopathological (7,8) and humoral studies (6)(7)(8)(9) have emphasized the depression of host humoral responsiveness and suggest an impairment of B-T-cell cooperation (6).…”

mentioning

confidence: 99%

The role of nonclassical Fc receptor-associated, Ag-B antigens (Ia) in rat allograft enhancement.

Soulillou¹,

Carpenter²,

d’Apice³

et al. 1976

The Journal of Experimental Medicine

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The ready availability of inbred strains, ability to withstand microvascular surgery, and the ease of production of immunological enhancement have made the rat a popular and valuable model for organ transplantation. A number of studies in the mouse employing skin allografts have demonstrated the central role of gene products of the major histocompatibility H-2 complex in the rejection process. Fragmentary understanding of the rat major histocompatibility gene complex (MHC) 1 has limited the general applicability of data obtained by studying rat organ transplantation. Because important differences exist between the immunobiology of skin and organ allografts (1), it is important to develop a full understanding of the rat MHC. Recent studies have indicated that rat gene products identical to or closely linked to the serologically defined Ag-B system function as immune response genes (2, 3) and stimulate the mixed lymphocyte culture response (4). These studies suggest, therefore, that the rat MHC bears close similarity to the more extensively mapped MHC regions of primates and the mouse.The phenomenon of passive enhancement of tumor and tissue allografts (1, 5) has been shown to be associated with only minimal alteration in cellular immune responsiveness in the host (6). In contrast, immunopathological (7,8) and humoral studies (6-9) have emphasized the depression of host humoral responsiveness and suggest an impairment of B-T-cell cooperation (6). Still, the mechanism by which passive immunization produces this deviation in the immune response remains speculative. An important recent advance has been the finding that, while antibodies of different classes (10) and physicochemical characteristics (11) can induce enhanced graft survival, antibodies specific for the products of the K and D regions of the mouse MHC are unnecessary (12). Similarly, in the rat,

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confidence: 99%

The role of nonclassical Fc receptor-associated, Ag-B antigens (Ia) in rat allograft enhancement.

Soulillou¹,

Carpenter²,

d’Apice³

et al. 1976

The Journal of Experimental Medicine

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“…43 IgG1 predominance leads to the concept that tolerance in pregnancy was a proof of the facilitation concept. 1,11 But what then of the non-producers? Moreover, there are species, such as primates, in which an anti-paternal cytotoxic alloantibody response is observed as early as first pregnancy, and this is the case for human alloantibodies.…”

Section: Humoral Compartmentmentioning

confidence: 99%

“…10 Moreover, in enhancement ⁄ facilitation phenomenon, continuous coexistence of antibodies and CTLs can be demonstrated. 11 But concepts of antibody-mediated selftolerance collapsed when Zinkernagel and Doherty demonstrated self-tolerance MHC restriction, as alloantibodies are unrestricted. For these 'active' processes, Schwartz's definition is the closest and applies to pregnancy, still too often viewed as total anti-paternal unresponsiveness, despite evidence of immunotrophism.…”

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confidence: 99%

REVIEW ARTICLE: Tolerance to the Foetal Allograft?

Chaouat¹,

Petitbarat

Dubanchet

et al. 2010

American J Rep Immunol

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“…In vivo studies, however, have employed special systems, allogeneic or immunized animals, hyperimmune sera (for a review see Voisin, 1971), irradiated mice (Vaage,. 1973) and spontaneously regressing tumours (Pierce, 1971).…”

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confidence: 99%

Effect of solubilized membrane antigens and tumour bearer serum on tumour growth in syngeneic hosts

Forni¹,

Comoglio

1974

Br J Cancer

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Immunological Facilitation, a Broadening of the Concept of the Enhancement Phenomenon

Cited by 46 publications

References 0 publications

The role of nonclassical Fc receptor-associated, Ag-B antigens (Ia) in rat allograft enhancement.

The role of nonclassical Fc receptor-associated, Ag-B antigens (Ia) in rat allograft enhancement.

REVIEW ARTICLE: Tolerance to the Foetal Allograft?

Effect of solubilized membrane antigens and tumour bearer serum on tumour growth in syngeneic hosts

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