Immunological features of endemic goiter

Costa, Alessandro; Benedetto, Vincenzo Di; Ricci, C; Borelli, P.; Fadda, Emanuela; Ravarino, Nicoletta; Torchio, Bruno; Dario, U.; Fragapane, P.; G, Varvello; Filippis, V De

doi:10.1016/0090-1229(86)90110-8

Cited by 10 publications

(10 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We observed that the number of NK cells (CD16+) in the clean‐up workers with thyroid diseases was significantly lower than in the patients without thyroid disorders. This contrasts to previous reports showing significantly increased or normal numbers of NK cells in patients with euthyroid nodular and diffuse goiter, however, without a history of radiation exposure [20–23]. In a previous study on atomic bomb survivors, no effect of radiation on the number of NK cells was found [24,25].…”

Section: Discussioncontrasting

confidence: 93%

Analysis of the Immune Status in Latvian Chernobyl Clean‐up Workers with Nononcological Thyroid Diseases

et al. 2001

View full text Add to dashboard Cite

The aim of the present work was to characterize the immune status of 385 individuals who participated in the 1986±90 clean-up work of the after effects of the Chernobyl nuclear power plant explosion. Fifty-nine Chernobyl clean-up workers developed the most common thyroid diseases; euthyroid nodular and diffuse goiter; 47 healthy blood donors were taken as controls. The levels of immunoglobulins (IgA, IgG and IgM), the numbers of peripheral blood leukocytes, lymphocytes, monocytes, T lymphocytes and their subpopulations (CD31, CD41, CD81), B lymphocytes (CD191), natural killer (NK) cells (CD161), classical and alternative pathway activity of complement (CH50, APH50), the C3 split product C3d, and neutrophil phagocytosis were determined in the peripheral blood. We found a significantly decreased number of CD161 cells (natural killer), of CD41 and CD81 T lymphocytes, a reduced neutrophil phagocytic activity as well as a significant complement activation in Chernobyl clean-up workers with and without thyroid diseases when compared with normal levels and those in the control group. In addition, the number of CD31 and CD41 cells was significantly higher in patients with nodular goiter when compared with that in patients with diffuse goiter. Levels of IgG and numbers of monocytes were significantly decreased in persons who worked in Chernobyl in 1986 during the first 2 months after the accident (with maximal radiation exposure) but were without correlation to thyroid disorders. Our results clearly reflect an impaired immune system in the Chernobyl clean-up workers even 10±14 years after the nuclear accident.

show abstract

Section: Discussioncontrasting

confidence: 93%

Analysis of the Immune Status in Latvian Chernobyl Clean‐up Workers with Nononcological Thyroid Diseases

et al. 2001

View full text Add to dashboard Cite

show abstract

“…However, the role played by this environmentally induced thyroid disorder and the de novo development of or the overlap with thyroid autoimmunity remains controversial; another point of uncertainty is whether iodine supplementation in iodine-deficient areas might be the trigger of thyroid autoimmunity (1,2). Thus, while in one study surgically removed goiters from patients living in endemic areas rarely showed lymphocytic infiltration (3), other investigators have reported the opposite (4,5). In the same context, discrepant data are also reported on the prevalence of antithyroid antibodies (ATA).…”

Section: Introductionmentioning

confidence: 85%

The Sardinian Autoimmunity Study: 3. Studies on Circulating Antithyroid Antibodies in Sardinian Schoolchildren: Relationship to Goiter Prevalence and Thyroid Function

Loviselli

Velluzzi²,

Mossa³

et al. 2001

Thyroid

View full text Add to dashboard Cite

The relationship among iodine intake, goiter prevalence, and thyroid autoimmunity remains controversial. In the present article, we report the prevalence of antithyroid antibodies (ATA) in relation to iodine intake, frequency of goiter, and thyroid function in a large group of Sardinian schoolchildren living in areas with borderline iodine sufficiency, or mild to moderate iodine deficiency. A total of 8,040 schoolchildren (4,194 males, 3,846 females, ages 6-15 years) from 29 communities were examined between 1986-1994. Thyroid size was assessed by palpation, according to the Pan American Health Organization (PAHO) criteria. In all cases antimicrosomal (MAb) or antithyroid peroxidase antibodies (TPOAb) and thyrotropin (TSH) were assayed. Urinary iodine was determined in a subgroup of 820 children. ATA was detected in 235 (2.92%) sera (88 males, 2.12%; 147 females, 3.82%; chi2 = 20.41, p < 0.0001). ATA prevalence ranged between 0.0%-7.3% in the 29 communities without any geographical correlation with goiter prevalence and urinary iodine excretion. However, ATA was more frequently detected in goitrous children, especially in females. The presence of ATA was not age-dependent in males, whereas a significant increase of ATA was observed in females older than 11 years of age. Seventy-seven (0.96%) children showed borderline to slightly increased serum TSH (>5.2-32 mU/L). Increased serum TSH concentration was more frequently found in children with ATA, especially at higher titers. In summary, our study in Sardinian schoolchildren indicates: (1) ATA display geographical heterogeneity, which seems to be unrelated to goiter prevalence and/or to iodine supply; (2) ATA are more frequently detected in females older than 11 years of age, suggesting that puberty has a role in determining the predominance in females of thyroid autoimmunity; (3) although most goitrous children are ATA-negative, the prevalence of ATA is increased in children with enlarged glands; (4) ATA is associated with an increased prevalence of subclinical hypothyroidism.

show abstract

“…Therefore, the Ministry of Health began the ' Iodine Defi ciency Diseases and Their Control Program ' in 1999. However, according to some studies, iodine supplementation in iodine-defi cient areas increases the prevalence of thyroid autoantibody positivity and lymphocytic infi ltration of the thyroid gland (3,9) . It has been reported that in previously endemic areas of Greece, the predominant form of non-toxic goiter in school children now seems to be HT (10) .…”

Section: Introductionmentioning

confidence: 99%

The frequency of Hashimoto thyroiditis in children and the relationship between urinary iodine level and Hashimoto thyroiditis

Doğan

Acikgoz²,

Açıkgöz³

et al. 2011

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

The aim of this study was to determine the frequency of thyroid autoimmunity in second grade primary school students and to examine the relationship between iodine and Hashimoto thyroiditis (HT). This was a cohort study performed with 1000 students. Urinary iodine levels, antithyroid peroxidase (anti-TPO) and antithyroglobulin (anti-Tg) antibodies were determined in all children. Children with anti-TPO or anti-Tg antibody positivity or with goiter were summoned for detailed examinations. In total, 36 cases (3.6%) were diagnosed as HT. The goiter frequency was found in 17.5% of the whole cohort. Additionally, iodine deficiency was found in 64.2% of all children. The median urinary iodine excretion was determined as 132 microg/L (range 382 microg/L) in the HT group, whereas it was 73 microg/L (range 390 microg/L) in children with goiter but without HT and 81 microg/L (range 394 microg/L) in normal children. The urinary iodine level of HT cases was significantly higher than the other two groups (p < 0.001). HT was also determined in 2% of patients with low urinary iodine levels, in 6.2% of patients with normal urinary iodine levels, and in 7.5% of patients with high urinary iodine levels. Our data demonstrates the close relationship between excessive iodine levels and autoimmunity.

show abstract

Immunological features of endemic goiter

Cited by 10 publications

References 23 publications

Analysis of the Immune Status in Latvian Chernobyl Clean‐up Workers with Nononcological Thyroid Diseases

Analysis of the Immune Status in Latvian Chernobyl Clean‐up Workers with Nononcological Thyroid Diseases

The Sardinian Autoimmunity Study: 3. Studies on Circulating Antithyroid Antibodies in Sardinian Schoolchildren: Relationship to Goiter Prevalence and Thyroid Function

The frequency of Hashimoto thyroiditis in children and the relationship between urinary iodine level and Hashimoto thyroiditis

Contact Info

Product

Resources

About