Immunological, hematological and biochemical changes induced by short term exposure to cadmium in catfish (Clarias gariepinus)

doi:10.12980/jclm.2.2014j57

Cited by 5 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, plasma GOT and GPT were considerably elevated in P. stellatus exposed to dietary Cd, indicating that Cd exposure may induce liver damage and disrupt the processing of amino acids and proteins in metabolic pathways. Consistent with the results of this study, increased levels of GOT and GPT resulting from exposure to Cd have been documented in other fish varieties, including P. olivaceus [32] and catfish species, such as Clarias gariepinus [42,43]. These findings suggest that Cd exposure contributes to liver injury by causing changes in GOT and GPT levels, thereby affecting the physiological and metabolic activities.…”

Section: Discussionsupporting

confidence: 91%

Toxic Impact of Dietary Cadmium on Bioaccumulation, Growth, Hematological Parameters, Plasma Components, and Antioxidant Responses in Starry Flounder (Platichthys stellatus)

Jung,

Kim,

Kang

2024

Fishes

View full text Add to dashboard Cite

Starry flounders (Platichthys stellatus) (average weight—114.69 ± 13 g, length—19.0 ± 0.21 cm) underwent a 4-week exposure to varying dietary cadmium (Cd) concentrations: 0, 10, 20, 40, 60, and 80 mg/kg. Bioaccumulation patterns were revealed in the intestine, kidney, liver, and gills in descending order of accumulation. Significant declines in growth indicators—body weight gain (BWG), specific growth rate (SGR), and feed efficiency ratio percentage (FER)—were evident at 80 mg Cd/kg for 2 weeks and beyond 60 mg Cd/kg for 4 weeks. Hematological parameters, including red blood cell (RBC) count, hematocrit (Ht), and hemoglobin (Hb), remarkably reduced at 80 mg Cd/kg for both 2 and 4 weeks. The total plasma protein reduced significantly after exposure to Cd for 2 and 4 weeks, alongside increased glucose levels, glutamic oxaloacetic transaminase (GOT), and glutamic pyruvate transaminase (GPT). Considerable increases in antioxidant responses—superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), and glutathione (GSH) levels—were observed after exposure to Cd for 2 and 4 weeks. P. stellatus exhibits a high accumulation of dietary Cd in specific tissues. Moreover, concentrations above 60 mg Cd/kg adversely affected the growth performance, hematological parameters, plasma components, and antioxidant responses.

show abstract

Section: Discussionsupporting

confidence: 91%

Toxic Impact of Dietary Cadmium on Bioaccumulation, Growth, Hematological Parameters, Plasma Components, and Antioxidant Responses in Starry Flounder (Platichthys stellatus)

Jung,

Kim,

Kang

2024

Fishes

View full text Add to dashboard Cite

show abstract

“…Besides, current information on the indirect effects of such sudden exposure to large amounts of toxic heavy metals via water quality assessment vis-à-vis their direct effects on fish health through evaluations of induced hematological, behavioral, and gill cellular changes are scanty. Similarly, although there are reports of gill histopathological and hematological changes in Clarias gariepinus (C. gariepinus) exposed to Cd 2+ , most of these reports have focused on chronic studies or in juveniles [23][24][25] compared to the present work involving adult C. gariepinus with well-developed accessory breathing organs following sudden exposure to large amounts of Cd 2+ . That is why the present study investigated the effects of acute Cd 2+ toxicity on fish water physicochemical characteristics in relation to induced behavioral and clinicopathological changes in the exposed African catfish, C. gariepinus.…”

Section: Introductionmentioning

confidence: 93%

Toxicopathological effects of acute cadmium chloride exposure of African Catfish, Clarias gariepinus

Abalaka

Oyelowo

Akande

et al. 2021

Toxicol. Environ. Health Sci.

View full text Add to dashboard Cite

Object There are increasing levels of global cadmium (Cd 2+ ) aquatic environmental pollution with untold consequences following either sudden exposure to large concentrations or prolong exposure to low doses. The investigation of sudden exposure to large concentrations of Cd 2+ toxicities in exposed fish, especially in the hardy and adaptable Clarias gariepinus (C. gariepinus) with accessory breathing organs will further elucidate on its toxicity pathways given the spates of industrial accidents-induced environmental pollution. Methods The experiment involved the use of 126 adult C. gariepinus exposed to various concentrations of cadmium chloride (CdCl 2 ) over a 96-h period, in triplicates, following 14-day acclimatization period. Results Initial behavioral agitations progressed to depression, including signs of respiratory distress, neurotoxicity, and death in some of the exposed fish. A median lethal concentration (LC 50 ) established for CdCl 2 was 10.48 mgL −1 in the exposed adult C. gariepinus. The exposure caused sudden deterioration in fish water quality with severe gill cellular damage, which provoked variable hematological responses in the exposed fish. Conclusion Cadmium chloride was more toxic to C. gariepinus adults than already reported for C. gariepinus fingerlings and juveniles based on the established LC 50 values. Sudden exposure to large concentration of CdCl 2 has the propensity to negatively impact fish health indirectly (changes in fish water quality) and directly (hemotoxicity and cellular damages).

show abstract

“…Also, the levels of AST production in this regard are relatively high in all treatments probably due to the prevailing environmental conditions that necessitate up-regulation of the immune system. In a related development, El-Said El-Boshy et al [12] reported that blood level activities of ALT and AST was significantly increased when the fish were exposed to 2, 5 and 10mg/L treatments for a period of 3 weeks. T 1 mean values in both 6 th and 8 th weeks of exposure are significantly higher than other treatments including the control probably due to high production and less utilization of the enzyme.…”

Section: Ast Production Levels In C Gariepinus Exposed To Sub-lethal Concentrations Of Cd Onlymentioning

confidence: 99%

“…Five treatments including control with two replicates in each treatment were set-up for the Cd, Vitamin A, C and E; and the sub-lethal exposures were run for a period of twelve (12) weeks. The treatments are 0% (control), 15%, 20%, 25% and 30% which translated into 12mg/L, 16mg/L, 20mg/L and 24mg/L of the LC 50 , respectively.…”

Section: Experimental Set-upmentioning

confidence: 99%

Evaluation of the Ameliorative Roles of Vitamins A, C and E on Aspartate Amino Transferase in <i>Clarias gariepinus</i> (Burchell, 1822) Fingerlings Exposed to Camium Chloride

Samuel¹,

Ofurum²,

Ayanwale³

et al. 2021

IJEE

View full text Add to dashboard Cite

The anthropogenic activities culminating in environmental pollution usually lead to release of plethora of pollutants such as cadmium calls for concern. The effects of CdCl 2 on the production of aspartate amino transferase (AST) in C. gariepinus and how they can be ameliorated through administration of vitamins were investigated. C. gariepinus fingerlings (whose initial weight ranged from 3-11g) were exposed to sub-lethal concentrations of Cd (00, 12mg/L, 16mg/L, 20mg/L and 24mg/L) with replicate in each case. In each case, 12mg/L of the vitamin was administered across all buds. Fresh concentrations of both toxicant and vitamins were administered every 72 hours for a period of 12 weeks every time the water medium was changed. The various treatments group include Cd only, CdVA, CdVC and CdVE. 3 samples of the fish were randomly selected and sacrificed from each aquarium tank every 2 weeks of the exposure period. The gills, kidneys and liver were excised from these specimens and homogenized in sodium phosphate buffer. From the results: in Cd only, the highest AST produced in the liver was 135.00±0.18nM/mg in T 1 . The highest AST produced in the kidneys of the fish was 145.00±0.18nM/mg in T 3 . The highest AST produced in the gill was 137.97±0.09nM/mg in T 1 . In CDVA samples, the highest AST produced in the liver was 132.19±0.18nM/mg in T 4 . The highest AST produced in the kidneys was 113.91±0.09nM/mg in T 1 . In the gills, the highest AST value was 120.94±0.36nM/mg in T 1 . In the samples exposed to CdVC, the highest AST produced in the liver was 128.44±0.36nM/mg in T 1 . The highest mean value of AST produced in the kidneys was 114.84±0.09nM/mg in T 3 . In the gills of the samples, the highest AST value was 125.16±0.27nM/mg in T 2 . In CdVE samples, the highest AST produced in the liver was 150.63±0.18nM/mg in T 2 . The kidneys' highest AST value of 125.78±0.27nM/mg was recorded in T 4 . In the gills of the samples, the highest AST produced in the gills of the fish was 133.28±0.09nM/mg in T 1 . There were general high production levels of AST in all treatments with the highest values recorded in the liver of CdVA, CdVC and CdVE groups mostly in samples exposed to lower concentrations. The kidneys in the Cd only group however, produced the highest AST value. The high production values of AST in all treatments suggest that the enzyme is a good biomarker of oxidative stress elicited by the presence of the toxicant.

show abstract

Immunological, hematological and biochemical changes induced by short term exposure to cadmium in catfish (Clarias gariepinus)

Cited by 5 publications

References 29 publications

Toxic Impact of Dietary Cadmium on Bioaccumulation, Growth, Hematological Parameters, Plasma Components, and Antioxidant Responses in Starry Flounder (Platichthys stellatus)

Toxic Impact of Dietary Cadmium on Bioaccumulation, Growth, Hematological Parameters, Plasma Components, and Antioxidant Responses in Starry Flounder (Platichthys stellatus)

Toxicopathological effects of acute cadmium chloride exposure of African Catfish, Clarias gariepinus

Evaluation of the Ameliorative Roles of Vitamins A, C and E on Aspartate Amino Transferase in <i>Clarias gariepinus</i> (Burchell, 1822) Fingerlings Exposed to Camium Chloride

Contact Info

Product

Resources

About

Immunological, hematological and biochemical changes induced by short term exposure to cadmium in catfish (Clarias gariepinus)

Cited by 5 publications

References 29 publications

Toxic Impact of Dietary Cadmium on Bioaccumulation, Growth, Hematological Parameters, Plasma Components, and Antioxidant Responses in Starry Flounder (Platichthys stellatus)

Toxic Impact of Dietary Cadmium on Bioaccumulation, Growth, Hematological Parameters, Plasma Components, and Antioxidant Responses in Starry Flounder (Platichthys stellatus)

Toxicopathological effects of acute cadmium chloride exposure of African Catfish, Clarias gariepinus

Evaluation of the Ameliorative Roles of Vitamins A, C and E on Aspartate Amino Transferase in &lt;i&gt;Clarias gariepinus&lt;/i&gt; (Burchell, 1822) Fingerlings Exposed to Camium Chloride

Contact Info

Product

Resources

About

Evaluation of the Ameliorative Roles of Vitamins A, C and E on Aspartate Amino Transferase in <i>Clarias gariepinus</i> (Burchell, 1822) Fingerlings Exposed to Camium Chloride