Immunological in vivo and in vitro examinations of Echinacea extracts

Bauer, R.; Jurcic, K.; Puhlmann, J.; Wagner, Verena

doi:10.1016/0378-8741(88)90021-9

Cited by 40 publications

(51 citation statements)

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“…A common property of all three echinacea species is to effect an increase in phagocytic activity. This was shown in early in vitro studies in Germany with echinacea juice on human cells and micro-organisms (Brandt, 1967;Krause, 1984;Coeugniet & Elek, 1987;Wildfeuer & Mayerhofer, 1994;Burger et al 1997) and later with ethanolic extracts after oral administration in the C-clearance test, with E. purpurea the most active species (Bauer et al 1988Bauer & Wagner, 1991). Extracts of the aerial parts of the three species demonstrated lower activity than the roots .…”

Section: Laboratory Studiesmentioning

confidence: 99%

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Herbal products: active constituents, modes of action and quality control

Wills¹,

Bone²,

Morgan³

2000

Nutr. Res. Rev.

146

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An overview is given of the current position of medicinal herbs in general in relation to usage, market and production, types of pharmacological activity and how they differ from conventional drugs. The increasing importance of quality and manufactured products is also discussed. A more detailed consideration of these issues is given in relation to echinacea, valerian and St John's wort as these herbs are well studied, are market leaders and have widespread community usage.

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Section: Laboratory Studiesmentioning

confidence: 99%

“…The rate of immune stimulation was much higher than that observed with administration by intramuscular injection . In contrast, echinacoside from E. angustifolia and E. pallida (which is often used as a quality marker for these species) has not demonstrated immune-enhancing activity (Bauer et al 1988).…”

Section: Laboratory Studiesmentioning

confidence: 99%

Herbal products: active constituents, modes of action and quality control

Wills¹,

Bone²,

Morgan³

2000

Nutr. Res. Rev.

146

View full text Add to dashboard Cite

show abstract

“…This compound is derived from the purple coneflower, and has been shown to activate macrophages, NK cells and other immune cells [99][100][101]. Moreover, it stimulates secretion of cytokines and increases the number of white blood cells in the circulatory system, enhancing phagocytosis and triggering the alternate complementary pathway [102,103]. Additionally, these phyto-extracts are potent candidates for therapeutic or preventive remedies of upper respiratory tract infections, common cold, urogenital infection and wound healing.…”

Section: Dcs Upon Immunomodulationmentioning

confidence: 99%

Understanding dendritic cell biology and its role in immunological disorders through proteomic profiling

Ferreira

Mathieu

Overbergh

2010

Proteomics Clinical Apps

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Dendritic cells (DC) have always been present on the bright spot of immune research. They have been extensively studied for the last 35 years, and much is known about their different phenotypes, stimulatory capacity, and role in the immune system. During the last 15 years, great attention has been given to studies on global gene and protein expression profiles during the differentiation and maturation processes of these cells. It is well understood that studying the proteome, together with information on the role of protein post-translational modifications (PTM), will reveal the real dynamics of a living cell. The rapid increase of proteomic studies during the last decade describing the differentiation and maturation process in DCs, as well as modifications brought by the use of different compounds that either increase or decrease their immunogenicity, reflects the importance of understanding the molecular processes behind the functional properties of these cells. In the present review, we will give an overview of proteomic studies focusing on DCs. Thereby we will concentrate on the importance of these studies in understanding DC behavior from a molecular point of view and how these findings have aided in understanding the differences in functional properties of these cells.

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“…Isobutylamides from E. purpurea and E. angustifolia roots also inhibit arachidonic acid metabolism to inflammatory prostaglandins and may account for some of Echinacea's antiinflammatory effects (Bauer et al 1988b). When testing the alcoholic extracts from Echinacea, the phagocytic enhancement was largely credited to isobutylamides content (Bauer et al 1988a, Bauer andWagner 1991). The isobutylamides are thought to cause Echinacea's topical effect, which is often described as tingling or tongue numbing (Bauer and Wagner 1991).…”

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confidence: 99%

Patterns of variation in lipophilic and hydrophilic constituents in flower developmental stages of Echinacea purpurea (L.) Moench cultivated in Slovakia

Mistríková¹,

Vaverková²

2009

PLANT SOIL ENVIRON

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The objective of this study was to examine and demonstrate how harvesting age (flower age) contribute to the variations in the quality of Echinacea purpurea (L.) Moench. The effects of different flower developmental stages on caffeic acid derivatives and isobutylamide content are described. These phytochemicals were extracted from fresh plants with 60% ethanol and quantified by the HPLC analysis. The results revealed that the quality of Echinacea is strongly influenced by the flower developmental stages. The highest content of both hydrophilic and lipophilic components in the anthodium of Echinacea plants were found in the third (mature) developmental stage, which is regarded as the optimum one for the harvest to obtain optimum yield levels.

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Immunological in vivo and in vitro examinations of Echinacea extracts

Cited by 40 publications

References 0 publications

Herbal products: active constituents, modes of action and quality control

Herbal products: active constituents, modes of action and quality control

Understanding dendritic cell biology and its role in immunological disorders through proteomic profiling

Patterns of variation in lipophilic and hydrophilic constituents in flower developmental stages of Echinacea purpurea (L.) Moench cultivated in Slovakia

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