Immunological induction with thymoglobulin: reduction in the number of doses in renal transplant from deceased donor

Moura, Lúcio Roberto Requião; Tonato, Eduardo José; Ferraz, E.; Filliponi, Thiago Corsi; Chinen, Rogério; Matos, Ana Cristina Carvalho de; Silva, Maurício Rodrigues Fregonesi da; Durão, Marcelino de Souza; Pacheco-Silva, Álvaro

doi:10.1590/s1679-45082011ao1838

Cited by 2 publications

(2 citation statements)

References 26 publications

(49 reference statements)

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“…In patients receiving prophylaxis (5 studies), reported rates of CMV infection during the first year post‐SOT were 5.2%, 30 26.0%, 24 45.4%, 31 50.0%, 22 and 50.2% 32 . According to studies conducted in Brazil, India, and South Korea, infection typically appeared after a median of 1–2 months postkidney or postliver transplantation 8,21,25,27,29,32–39 . The diagnostic criteria used for ascertaining CMV infection were similar across studies—whereby a patient was considered to have CMV infection through a positive PCR and/or pp65‐antigenemia assay for CMV.…”

Section: Resultsmentioning

confidence: 99%

“…The diagnostic criteria used for ascertaining CMV infection were similar across studies—whereby a patient was considered to have CMV infection through a positive PCR and/or pp65‐antigenemia assay for CMV. However, specimens used for these analyses varied extensively, consisting of either whole blood, plasma, serum, or body fluid, collected periodically during CMV monitoring (frequency and duration of monitoring were not reported) 21–22,24–26,28–35,37,40,41 . In addition, thresholds used to determine whether a patient was positive on the quantitative PCR assay were heterogeneous—such as ≥500 copies/mL (South Korea), 31 ≥1000 copies/mL (India), 24 or >2.500 international units (Brazil) 8,41 .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology, management, and burden of cytomegalovirus in solid organ transplant recipients in selected countries outside of Europe and North America: A systematic review

Silva

Tokat

Cai

et al. 2023

Transplant Infectious Dis

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BackgroundCytomegalovirus (CMV) is a frequent infectious complication following solid organ transplantation (SOT). Considering significant differences in healthcare systems, a systematic review was conducted to describe the epidemiology, management, and burden of CMV post‐SOT in selected countries outside of Europe and North America.MethodsMEDLINE, Embase, and Cochrane databases were searched for observational studies in SOT recipients across 15 countries in the regions of Asia, Pacific, and Latin America (search period: January 1, 2011 to September 17, 2021). Outcomes included incidence of CMV infection/disease, recurrence, risk factors, CMV‐related mortality, treatment patterns and guidelines, refractory and/or resistant CMV, patient‐reported outcomes, and economic burden.ResultsOf 2708 studies identified, 49 were eligible (n = 43/49; 87.8% in adults; n = 34/49, 69.4% in kidney recipients). Across studies, selection of CMV preventive strategy was based on CMV serostatus. Overall, rates of CMV infection (within 1 year) and CMV disease post‐SOT were respectively, 10.3%–63.2% (9 studies) and 0%–19.0% (17 studies). Recurrence occurred in 35.4%–41.0% cases (3 studies) and up to 5.3% recipients died of CMV‐associated causes (11 studies). Conventional treatments for CMV infection/disease included ganciclovir (GCV) or valganciclovir. Up to 4.4% patients were resistant to treatment (3 studies); no studies reported on refractory CMV. Treatment‐related adverse events with GCV included neutropenia (2%–29%), anemia (13%–48%), leukopenia (11%–37%), and thrombocytopenia (13%–24%). Data on economic burden were scarce. imageConclusionOutside of North America and Europe, rates of CMV infection/disease post‐SOT are highly variable and CMV recurrence is frequent. CMV resistance and treatment‐associated adverse events, including myelosuppression, highlight unmet needs with conventional therapy.

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