Immunological Landscape of HER-2 Positive Breast Cancer

Moragón, Santiago; Hernándo, Cristina; Martinez-Martinez, Maria Teresa; Tapia, Marta; Ortega-Morillo, Belen; Lluch, Ana; Bermejo, Begoña; Cejalvo, Juan Miguel

doi:10.3390/cancers14133167

Cited by 6 publications

(1 citation statement)

References 156 publications

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“…Moreover, CVs have only had sporadic clinical success throughout testing. All phase 3 clinical studies so far have been negative for therapeutic BC vaccines, which were initially examined in metastatic disease and later in the adjuvant context [218]. As disease loads and immune suppression are both low, there is growing interest in using CVs for disease interception and prevention [219].…”

Section: Therapeutic Cancer Vaccinesmentioning

confidence: 99%

Unveiling the Immune Microenvironment’s Role in Breast Cancer: A Glimpse into Promising Frontiers

Kotsifaki,

Alevizopoulos,

Dimopoulou

et al. 2023

IJMS

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Breast cancer (BC), one of the most widespread and devastating diseases affecting women worldwide, presents a significant public health challenge. This review explores the emerging frontiers of research focused on deciphering the intricate interplay between BC cells and the immune microenvironment. Understanding the role of the immune system in BC is critical as it holds promise for novel therapeutic approaches and precision medicine strategies. This review delves into the current literature regarding the immune microenvironment’s contribution to BC initiation, progression, and metastasis. It examines the complex mechanisms by which BC cells interact with various immune cell populations, including tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). Furthermore, this review highlights the impact of immune-related factors, such as cytokines and immune checkpoint molecules. Additionally, this comprehensive analysis sheds light on the potential biomarkers associated with the immune response in BC, enabling early diagnosis and prognostic assessment. The therapeutic implications of targeting the immune microenvironment are also explored, encompassing immunotherapeutic strategies and combination therapies to enhance treatment efficacy. The significance of this review lies in its potential to pave the way for novel therapeutic interventions, providing clinicians and researchers with essential knowledge to design targeted and personalized treatment regimens for BC patients.

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Section: Therapeutic Cancer Vaccinesmentioning

confidence: 99%