Immunological Observations in Chronic Mucocutaneous Candidiasis

Specific inhibition of in vitro Candida-induced lymphocyte proliferation by polysaccharidic antigens present in the serum of patients with chronic mucocutaneous candidiasis.

“…This inhibitory activity appeared to be directly dependent on a patient's serum concentration, allowing for its quantization not achieved in previous studies (2,6,8,10,11). These previous observations have shown that specific inhibition for Candida-induced proliferation was found in most (13 out of 19) CMCC patients' sera tested (2,9,11).…”

“…In some patients, the restoration of cellular responses to CA paralleled a clinical improvement with antifungal therapy, suggesting that cellular abnormalities were not a result of intrinsic lymphocytic defect (6,7). An inhibitory activity of normal lymphocyte proliferation was described in sera from 19 CMCC patients, all of them presenting an immune cellular defect (2,6,(8)(9)(10)(11)(12). In 13 cases the specificity of this inhibition seemed to be restricted to CA-induced proliferation (2,9,11).…”

Inhibition of lymphoproliferation by hyperlipoproteinemic plasma.

“…These disorders include chronic mucocutaneous candidiasis (11,17), solid tumors (18,19), primary tumors of lymphoid tissues (20,21), and systemic lupus erythematosus (22).…”

Lymphocyte Sensitization in Advanced Malignant Disease: A Study of Serum Lymphocyte Depressive Factor

“…Cooperband et al (1968) (Heilman and MacFarland, 1966); hepatitis (Paronetto and Popper, 1970); ataxia telangiectasia (MacFarlin and Oppenheim, 1969); secondary syphilis (Levene et al, 1969); chronic candidiasis (Canales et al, 1969); Hodgkin's disease (Trubowitz, Masek and del Rosario, 1966); as well as cancer (Trubowitz et al, 1966;Salk, 1967;and others). With the present highly sensitive and quantitative method of assessing lymphocyte sensitization, the titre of LDF in health and disease can readily be determined.…”