Immunological Phenomena in Leprosy and Related Diseases

Turk, J.L.; Bryceson, A. D. M.

doi:10.1016/s0065-2776(08)60185-6

Cited by 255 publications

(104 citation statements)

References 86 publications

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“…Cell-mediated immunity (CMI) including delayed-type hypersensitivity (DTH) and cytotoxic T-lymphocyte responses is implicated to be deeply involved in protection against such pathogens as human immunodeficiency virus [ 11, bovine leukemia virus [2], Leishmania major [3] Mycobacterium leprae [4] and Treponema pallidurn [5]. Thus, activation of the cell-mediated, rather than the antibody-mediated, arm of the immune system is considered to be required in a vaccine against these pathogens [6].…”

Section: Introductionmentioning

confidence: 99%

Oligomannose‐coated liposomes as an adjuvant for the induction of cell‐mediated immunity

et al. 1995

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The effect of the coating of ovalbumin-reconstituted liposomes with various oligosaccharides on their immunogenicity was investigated in mice. The coating of liposomes with oligomannose or yeast mannan drastically enhanced their ability to induce an ovalbumin-specific delayed-type footpad swelling response with a peak at 24 to 48 h post-challenge. Among various oligosaccharides tested, only those with mannose residue at the nonreducing termini manifested the activity when applied to liposomes. Since such oligosaccharides are ubiquitously found in the body, these results suggested the usefulness of oligomannosecoated liposomes as a safe adjuvant for the induction of cellmediated immunity.

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Section: Introductionmentioning

confidence: 99%

Oligomannose‐coated liposomes as an adjuvant for the induction of cell‐mediated immunity

et al. 1995

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“…Several investigator s have found markedly increased concentra tions of antibodies aga inst mycobacte rial antigens in sera of patients with lepromatous leprosy , wh ereas such antibodies are detected less frequently and in lowe r concentrations in patients with tuberculoid leprosy (9)(10)(11)(12)(13) .…”

Section: Ria For Antibodies Against One Cross-react Ing Component Of mentioning

confidence: 99%

“…It is we ll established that patients with lepromatous leprosy are characte rized by lack of cell mediated immune reactions against M. leprae when studied with both in vivo (10,14) and in vitro technique s (15)(16)(17)(18) .…”

Section: Ria For Antibodies Against One Cross-react Ing Component Of mentioning

confidence: 99%

“…Time course of deve lopment of cell mediated-and humoral immunity in different forms of leprosy In lepromatous forms of the disease , cell med iated immune reactions against compcnents of M. leprae are absent or weak (10,(14)(15)(16)(17)(18) . Although the concentration varies ' in individual cases , antibodies are usually demonstrable in the se patients (9)(10)(11)(12)(13)21) .…”

Section: Ria For Antibodies Against One Cross-react Ing Component Of mentioning

confidence: 99%

“…Although the concentration varies ' in individual cases , antibodies are usually demonstrable in the se patients (9)(10)(11)(12)(13)21) . In experi mental animals and in patients with lepromatou s forms of the disease, antibodies will thus be the mo st sensitive indicator of infection .…”

Section: Ria For Antibodies Against One Cross-react Ing Component Of mentioning

confidence: 99%

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Radioimmunoassay and other serologic tests and their application in epidemiological work

Harboe¹

1981

Leprosy Review

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Various types of radioimmunoassay (RIA) have been deve loped for demonstration and quantification of antibodies aga inst My cobacterium l eprae .They may be classified as fol lows : a.RIA for antibodies against one cross-reacting comp onent of M. leprae . b.RIA for antibodies against M. leprae spec ific antigenic deter minants . c.RIA demonstrating antibodies of a particular immunoglobulin class against M. leprae . The purpose of th is paper is to present our current knowledge on the se variou s radioimmunoassays and the ir informative value in human leprosy and in monitor ing the deve lopment of systemic myco bacterial infection after exper imental inoculation of armadillos . Fin ally, the plans for further deve lopment and tests of these assays in our laboratory will be discussed .RIA for antibodies against one cross-react ing component of M. lepraeThe RIA for demonstration and quantification of antibodies against M. leprae component 7 (anti-Ml 7) was deve loped (1, 2) as an example of a te st of this kind .By de finition , increased concentrations of anti-Ml 7 are not specific for leprosy but are also expected to occur in other mycobacterial infections .As with anti-polysaccharide antibodies demonstrated by the passive haemagglutination test of Midd lebrook and Dubos (3) , anti Ml 7 is expected to occur in norma l individuals due to stimulat ion by cross-reacting antigens in environmental mycobacteria .Th e amount of anti-Ml 7 antibodies synthesized during mycobac terial infection is expected to be influenced not only by antigenic stimulation due to the infection per se but also by the individual 's previous exposure to other mycobacteria containing antigens cross reacting with M. leprae antigen 7.Strong immune responses may be obtained after primary exposure 19

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Leishmania tropica Infections in Travellers

Rau¹

1976

Arch Dermatol

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Immunological Phenomena in Leprosy and Related Diseases

Cited by 255 publications

References 86 publications

Oligomannose‐coated liposomes as an adjuvant for the induction of cell‐mediated immunity

Oligomannose‐coated liposomes as an adjuvant for the induction of cell‐mediated immunity

Radioimmunoassay and other serologic tests and their application in epidemiological work

Leishmania tropica Infections in Travellers

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