Immunological profiles of children with recurrent otitis media with or without spontaneous tympanic membrane perforation and of children with recurrent respiratory infections

Torretta, Sara; Rosazza, Chiara; Baselli, Lucia Augusta; Berti, Cristiana; Bosi, Pietro; Dellepiane, Rosa Maria; Folino, Francesco; Milani, Gregorio P.; Marchisio, Paola

doi:10.1016/j.ijporl.2022.111219

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…This study was conducted at the otitis media pediatric outpatient clinic of the Ospedale Maggiore Policlinico, Milan (Italy), from 2019 to 2022. All consecutive children referring to the outpatient clinic for a first-time visit for rAOM 2 were eligible and the following information was extracted: sex, age (≤2 and >2 years), date of first visit and history of STMP. Data were obtained from patient’s online medical records.…”

Section: To the Editorsmentioning

confidence: 99%

Referrals for Recurrent Acute Otitis Media With and Without Spontaneous Tympanic Membrane Perforation Through COVID-19: A Cross-Sectional Comparative Study

Tuzger,

Milani,

Folino

et al. 2023

Pediatric Infectious Disease Journal

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Section: To the Editorsmentioning

confidence: 99%

Referrals for Recurrent Acute Otitis Media With and Without Spontaneous Tympanic Membrane Perforation Through COVID-19: A Cross-Sectional Comparative Study

Tuzger,

Milani,

Folino

et al. 2023

Pediatric Infectious Disease Journal

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Otitis media: Interactions between host and environment, immune and inflammatory responses

Nokso-Koivisto,

Ehrlich,

Enoksson

et al. 2024

International Journal of Pediatric Otorhinolaryngology

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Recurrent upper respiratory tract infections in early childhood: a newly defined clinical condition

Corsello,

Milani,

Picca

et al. 2024

Ital J Pediatr

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Background Recurrent Upper Respiratory Tract Infections (R-URTIs) pose a significant challenge in pediatric healthcare, affecting both children and their families. This study aimed to investigate the prevalence, risk factors, and clinical implications of R-URTI in children aged 0–5 years. Methods This observational study involved a sample of 483 children aged 0–5 years, focusing on establishing a practical and dynamic definition of R-URTI. Family pediatricians prospectively collected socio-demographic information, medical history, and recorded the occurrence of URTI episodes. Children were followed from recruitment until March 2021, predating the COVID-19 outbreak. Results A substantial prevalence of R-URTIs was found, estimating it at 5–10% among this age group. To define R-URTI, a practical and dynamic criterion was proposed: children experiencing a minimum of four URTI episodes, each lasting four days or more, within a six-month period, with intervals of well-being in between. Conclusions The study highlighted that specific risk factors for R-URTI were elusive, suggesting that this condition may affect children regardless of their family or clinical history. Moreover, the study’s stratification by age group and times of observation facilitated patient-specific clinical decision-making. The proposed definition may represent a valuable tool for clinicians in diagnosing and addressing R-URTI cases.

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Immunological profiles of children with recurrent otitis media with or without spontaneous tympanic membrane perforation and of children with recurrent respiratory infections

Cited by 3 publications

References 38 publications

Referrals for Recurrent Acute Otitis Media With and Without Spontaneous Tympanic Membrane Perforation Through COVID-19: A Cross-Sectional Comparative Study

Referrals for Recurrent Acute Otitis Media With and Without Spontaneous Tympanic Membrane Perforation Through COVID-19: A Cross-Sectional Comparative Study

Otitis media: Interactions between host and environment, immune and inflammatory responses

Recurrent upper respiratory tract infections in early childhood: a newly defined clinical condition

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