Immunological Properties of an Antibody Containing a Fluorescent Group.

Coons, Albert H.; Creech, Hugh J.; Jones, R. Norman

doi:10.3181/00379727-47-13084p

Cited by 870 publications

(334 citation statements)

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“…Immunohistochemistry is the localization of antigens or proteins in cells of a tissue section exploiting the principle of antigen-antibody interactions that are visualized by a marker in biological tissues [30][31][32]. Animals were sacrificed 5 days post MCAo.…”

Section: Immunohistochemistrymentioning

confidence: 99%

The free fatty acid metabolome in cerebral ischemia following human mesenchymal stem cell transplantation in rats

Paik

Ahn

et al. 2009

Clinica Chimica Acta

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Section: Immunohistochemistrymentioning

confidence: 99%

The free fatty acid metabolome in cerebral ischemia following human mesenchymal stem cell transplantation in rats

Paik

Ahn

et al. 2009

Clinica Chimica Acta

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“…Although Albert Coons had started his early studies on fluorescently labeled antibodies in the 1940s, 77 the blooming of immunohistochemistry in diagnostic histopathology and research started mainly after reliable reagents became commercially available in the mid-1970s. In the late 1960s and early 1970s, we studied cholestatic liver tissue using enzyme histochemical techniques, including those for gamma-glutamyl transpeptidase (␥-GT), adenosine triphosphatase (ATPase), and nonspecific alkaline phosphatase (ALP).…”

Section: Cholestasismentioning

confidence: 99%

The amazing universe of hepatic microstructure†

Desmet

2009

Hepatology

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An informal review is presented by the author of his 50 years of involvement in practice and research in hepatopathology. Some background for the author's attitude and meandering pathway into his professional career serves as introduction to a short discussion of the main topics of his interest and expertise. Histogenesis of liver cancer was the theme of early work for a Ph.D. thesis, the results of which were lost into oblivion due to local rules and circumstances, but were rescued three decades later. His conclusions about the cells of origin of liver cancer remain concordant with the newer concepts in the field after nearly half a century. Studies in the field of chronic hepatitis became a long saga, involving the first classification of this syndrome by "the Gnomes" in 1968, histochemical investigations of viral antigens, lymphocyte subsets and adhesion molecules, and a quarter century later, the creation of a new classification presently in use. Cholestasis was a broadening field in diagnostic entities and involved the study of liver lesions, comprising pathways of bile regurgitation (including reversed secretory polarity of hepatocytes) and so-called ductular reaction. The latter topic has a high importance for the various roles it plays in modulating liver tissue of chronic cholestasis into biliary cirrhosis, and as the territory of hepatic progenitor cells, crucial for liver regeneration in adverse conditions and in development of liver cancer. Study of the embryology of intrahepatic bile ducts helped to clarify the strange appearance of the ducts in "ductal plate configuration" in several conditions, including some forms of biliary atresia with poor prognosis and all varieties of fibrocystic bile duct diseases with "ductal plate malformation" as the basic morphologic lesion. (HEPATOLOGY 2009;50: 333-344.)

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“…Estudos recentes definem micrometástases como a presença de uma única célula, ou grupo de até cinco células detectáveis por métodos imunoistoquímicos em linfonodos e médula óssea. Grupos maiores do que cinco células já podem ser reconhecidos por exame histológico convencional e por isso são chamados de metástases 4 .…”

Section: Micrometástasesunclassified

Novas perspectivas no estadiamento e tratamento do câncer de esôfago

Fonseca

Furlan

Ferranti

et al. 2007

ABCD, arq. bras. cir. dig.

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InTRODUÇÃOO câncer de esôfago apresenta-se como uma das neoplasias mais freqüentes e letais. Nas últimas décadas sua incidência vem aumentando consideravelmente com altas taxas de mortalidade em vários países. A doença predomina em faixas etárias avançadas, com maior ocorrência entre a sexta e sétima década de vida, e no sexo masculino, com razão de 4:1 em relação ao minino .Sua incidência varia geograficamente. É alta sobretudo em países como a China, Japão, Turquia, Cingapura A taxa de sobrevida geral após cinco anos é de aproximadamente 10% nas populações ocidentais, em contraste com a de 4% observada na década de 1970 . Apesar desta melhora na sobrevida, seu prognóstico continua insatisfatório e seu tratamento merece novos estudos na busca de melhores resultados.A classificação TNM é utilizada para determinar o grau de disseminação da doença e auxiliar na estimativa do prognóstico, levando em consideração principalmente o número de linfonodos acometidos. Kunisaki et al. 15 , através de 113 esofagectomias, compararam 5 métodos de estadiamento diferentes, observando que os que consideravam o número de linfonodos acometidos ao invés dos padrões de distribuição anatômica das metástases linfonodais, obtiveram melhor relação entre estadiamento e prognóstico. A presença de metástases linfonodais é vista, em muitos estudos, como um fator prognóstico independente. Estes estudos ressaltam a grande importância da realização de estadiamento linfonodal o mais acurado possível.Os métodos atualmente utilizados para ele no pré-operatório são o ultrassom endoscópico, tomografia computadorizada helicoidal e a tomografia com emissão de pósitrons. Ainda assim, estes métodos apresentam baixa

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Immunological Properties of an Antibody Containing a Fluorescent Group.

Cited by 870 publications

References 0 publications

The free fatty acid metabolome in cerebral ischemia following human mesenchymal stem cell transplantation in rats

The free fatty acid metabolome in cerebral ischemia following human mesenchymal stem cell transplantation in rats

The amazing universe of hepatic microstructure†

Novas perspectivas no estadiamento e tratamento do câncer de esôfago

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