Immunological properties of Andean starch films are independent of their nanometric roughness and stiffness

Torres, Fernando G.; Troncoso, Omar P.; Gamucci, Olimpia; Corvaglia, Stefania; Brunetti, Virgilio; Bardi, Giuseppe

doi:10.1016/j.ijbiomac.2015.02.008

Cited by 14 publications

(10 citation statements)

References 23 publications

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“…Because we prepared both starch NP suspensions in the same way and the size range of the particles was similar, we hypothesize that the differences in the starch material could be responsible for the dissimilar results. This hypothesis would agree with our previous results obtained with starch films from diverse Andean‐native sources , indicating that their immunological properties were not directly correlated with film roughness, or stiffness.…”

Section: Discussionsupporting

confidence: 92%

“…Monocytes/macrophages recognize some of the polymers used for biomedical purpose as non‐self, triggering unforeseen immune reactions . We have recently shown that starch films derived from different types of potatoes have a specific ability to interact with the immune cell surface , and the response may be related to the different molecular structures of the various starches. The aim of the present study, was to investigate the reaction of human monocytes primed with two different types of Andean‐native starch nanoparticles, focusing on the release of monocyte‐derived pro‐inflammatory cytokines, and their consequences.…”

Section: Introductionmentioning

confidence: 99%

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Human monocyte response to Andean-native starch nanoparticles

et al. 2016

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We used starches from two different Andean-native tubers to prepare nano-sized particles, and tested their ability to stimulate inflammatory reactions in human monocytes. Our data show that the release of inflammatory cytokines by monocytes can be differentially modulated by the administration of non-toxic doses of nanoparticles synthesized from the starch of the Andean sub-species Solanum tuberosum and Solanum goniocalyx. Furthermore, we observed a starch-nanoparticle-specific increase in inflammatory chemokine-dependent migration, and an up-regulation of immunoglobulin receptor CD16. Based on this preliminary study, we conclude that different potato starch nanoparticles possess specific properties that can induce immune responses and may be employed as immune modulators in the future.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Human monocyte response to Andean-native starch nanoparticles

et al. 2016

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“…Increasing the surface roughness can decrease or not affect the proliferation and/or differentiation of leukocytes, keratinocytes, and monocytes; however, it can improve osteoblast proliferation on the surface. [206][207][208] (iv) Even in one cell type, the surface roughness can affect different cell functions including cell adhesion, migration, proliferation, and differentiation in various ways. Increasing the surface roughness reduces the proliferation and increases the differentiation of osteoblasts.…”

Section: Impact Of Biomaterials Surface Physical Properties On Biologimentioning

confidence: 99%

Biological responses to physicochemical properties of biomaterial surface

et al. 2020

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“…Starch can be used to produce films with nanostructured surfaces, NPs, as well as hetero-materials nanocomposites. The acid hydrolysis can remove the amorphous domains and break down starch granules to NPs from few (5–30 nm) to several hundred of nanometers (100–300 nm) [31,32,33,34,35,36,37,38,39].…”

Section: Natural Polysaccharides and Polysaccharide Nanomaterialsmentioning

confidence: 99%

Natural Polysaccharide Nanomaterials: An Overview of Their Immunological Properties

Torres

Troncoso

Pisani

et al. 2019

IJMS

204

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Natural occurring polymers, or biopolymers, represent a huge part of our planet biomass. They are formed by long chains of monomers of the same type or a combination of different ones. Polysaccharides are biopolymers characterized by complex secondary structures performing several roles in plants, animals, and microorganisms. Because of their versatility and biodegradability, some of them are extensively used for packaging, food, pharmaceutical, and biomedical industries as sustainable and renewable materials. In the recent years, their manipulation at the nanometric scale enormously increased the range of potential applications, boosting an interdisciplinary research attempt to exploit all the potential advantages of nanostructured polysaccharides. Biomedical investigation mainly focused on nano-objects aimed at drug delivery, tissue repair, and vaccine adjuvants. The achievement of all these applications requires the deep knowledge of polysaccharide nanomaterials’ interactions with the immune system, which orchestrates the biological response to any foreign substance entering the body. In the present manuscript we focused on natural polysaccharides of high commercial importance, namely, starch, cellulose, chitin, and its deacetylated form chitosan, as well as the seaweed-derived carrageenan and alginate. We reviewed the available information on their biocompatibility, highlighting the importance of their physicochemical feature at the nanoscale for the modulation of the immune system.

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Immunological properties of Andean starch films are independent of their nanometric roughness and stiffness

Cited by 14 publications

References 23 publications

Human monocyte response to Andean-native starch nanoparticles

Human monocyte response to Andean-native starch nanoparticles

Biological responses to physicochemical properties of biomaterial surface

Natural Polysaccharide Nanomaterials: An Overview of Their Immunological Properties

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