Immunological properties of the surface of parasitic nematodes

Mackenzie, Charles D.; Preston, Patricia M.; Ogilvie, Bridget M.

doi:10.1038/276826a0

Cited by 105 publications

(54 citation statements)

References 9 publications

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“…The adherence of these cells to L3 (and to other stages) of N. dubius in the presence of normal serum was therefore considered to be a consequence of complement activation which presumably resulted in attachment of C3b to the cuticle, allowing the cells to adhere via their C3 receptors. Cell adherence probably resulting from complement fixation has previously been reported for larvae of the nematodes Ascaris suum (Ziprin and Jeska, 1975), Trichinella spiralis and Nippostrongylus brasiliensis (MacKenzie et al, 1978).…”

Section: Discussionmentioning

confidence: 62%

“…In this case, adherence was probably mediated by antibodies which bound to the surface of the parasites. Antibodies directed against cuticular antigens have been demonstrated in the sera of mice infected with A. suum (Leventhal and Soulsby, 1976), T. spiralis (MacKenzie et al, 1978) and Ancylostoma caninum (Vetter and Klaver-Wesserling, 1978).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, I^. dubius larvae, like Schistosoma mansoni schistosomulae and T. spiralis larvae (MacKenzie et al, 1978), are susceptible to attack by activated host cells whose action seems to depend on attachment to the parasite. The identity of the cells involved in damaging N. dubius is not clear, although activated macrophages have been shown to adhere in vivo (Chaicumpa, Jenkin and Fischer, 1977).…”

Section: Discussionmentioning

confidence: 99%

“…The identity of the cells involved in damaging N. dubius is not clear, although activated macrophages have been shown to adhere in vivo (Chaicumpa, Jenkin and Fischer, 1977). Mice immune to N. dubius exhibit a marked eosinophilia, and it is possible that these cells also participate in the killing process as has been suggested for T. spiralis (MacKenzie et al, 1978). LocaHsed breakdown of the cuticle and invasion of the subcuticular tissues of ^.…”

Section: Discussionmentioning

confidence: 99%

“…Studies with various parasitic nematodes have similarly shown that host antibodies directed against cuticular antigens can promote attachment of macrophages and other cells to the cuticle (Leventhal and Soulsby, 1976;MacKenzie, Preston and Ogilvie, 1978). Complement-dependent adherence of cells to nematode larvae has also been reported (MacKenzie et al, 1978;Ziprin and Jeska, 1975), although the raechanism(s) by which the complement is activated have not been investigated in detail.…”

Section: Introductionmentioning

confidence: 99%

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ALTERNATIVE PATHWAY ACTIVATION OF COMPLEMENT BY A MURINE PARASITIC NEMATODE (NEMATOSPIROIDES DUBIUS)

Prowse

Jenkin

1979

Aust J Exp Biol Med

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Summary The cuticular surface of the infectious third‐stage larvae of Nematospiroides dubius activates complement via the alternative pathway. Sensitisation of larvae with complement or with antibodies from the serum of immune mice (resistant to reinfection) promoted the adherence of mouse peritoneal exudate cells to the larval cuticle during incubation in vitro. The infectivity of larvae sensitised with antibody or complement was significantly reduced after incubation with cells from immune mice.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

ALTERNATIVE PATHWAY ACTIVATION OF COMPLEMENT BY A MURINE PARASITIC NEMATODE (NEMATOSPIROIDES DUBIUS)

Prowse

Jenkin

1979

Aust J Exp Biol Med

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Diagnosis and Assessment of Human Filarial Infections: Current Status and Challenges

Mackenzie¹,

Souza²,

Geary³

2022

Human and Animal Filariases

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Activation of complement, the induction of antibodies to the surface of nematodes and the effect of these factors and cells on worm survival in vitro

et al. 1980

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This report describes the effect on various stages in the life cycle of the nematodes T. spiralis and N. brasiliensis of complement, antibodies from rats infected with these parasites and several different cell types. The cuticle of the infective larvae and adult worms of both nematode species activates complement via the alternative pathway, but the cuticle of newborn T. spiralis lacks this property initially. As newborn larvae grow, however, the newly formed cuticle in the midregion of their body is able to activate complement. Rats infected with either nematode species produce antibodies to the cuticle of all life cycle stages which show marked specificity to each stage in the life cycle. Whereas the cuticle of T. spiralis reacts evenly over the entire surface both to complement and to antibodies, the reaction of the cuticle of N . brasiliensis to either reagent is patchy. Infective larvae of N. brasiliensis were killed in vitro in the presence of complement, by neutral red-positive peritoneal macrophages which were nonadherent to plastic. The infective and newborn larvae of T. spiralis were killed by eosinophil-enriched cell populations and antibodies. The speed of eosinophil killing of the T. spiralis larvae was enhanced when the serum was freshly collected and when the eosinophil suspension also contained neutral red-positive nonadherent macrophages. Newborn larvae of T. spiralis and infective larvae of N . brasiliensis assumed a rigid appearance at death. Infective larvae of T. spiralis burst, extruding their internal organs through their cuticle weakened by antibodies and the cells.

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Immunological properties of the surface of parasitic nematodes

Cited by 105 publications

References 9 publications

ALTERNATIVE PATHWAY ACTIVATION OF COMPLEMENT BY A MURINE PARASITIC NEMATODE (NEMATOSPIROIDES DUBIUS)

ALTERNATIVE PATHWAY ACTIVATION OF COMPLEMENT BY A MURINE PARASITIC NEMATODE (NEMATOSPIROIDES DUBIUS)

Diagnosis and Assessment of Human Filarial Infections: Current Status and Challenges

Activation of complement, the induction of antibodies to the surface of nematodes and the effect of these factors and cells on worm survival in vitro

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