Immunological Role of the Cellular Constituents of the Decidua in the Maintenance of Semiallogeneic Pregnancya

Characterization of Peripheral Blood and Peritoneal Fluid Mononuclear Cell Subsets in Fertile and Infertile Women

“…Between 10 and 20% of all couples seeking evaluation are so diagnosed [2], While the treatment offered is generally similar in the form of assisted reproduction, there is reason to believe that causes of unexplained infertility are dissimilar and include: (1) a random delay in conception [3]; (2) abnor mal folliculogenesis [4]; (3) spermatozoan dysfunction [5]; (4) peritoneal fluid inhibitory (PF) factors [6], and (5) ab errant immune responses [7], It has been shown that both women with unexplained infertility and women with min imal and mild endometriosis (a seeming form of unex plained infertility) have significant changes in the compo…”

Oxytocin-induced Prostaglandin E2(PGE2) Synthesis is Regulated by Progesterone via Oxytocinase in Ishikawa Cells

“…The endometrial PGE 2 :PGF 2 a ratio was higher in rhesus monkeys during the preimplantation stage of gestation [26]. The rise in PGE 2 is considered favorable for immunosuppression and decidualization in the endometrium at the time of implantation [27,28], which are endometrial responses to invading trophoblast cells. Furthermore, other cytokines such as interleukin-1, endothelin-1, and epidermal growth factor that are reported to be upregulated with progesterone treatment may also influence PGE 2 [29 ± 32].…”

Superovulation in the Treatment of Unexplained Infertility

“…27 Furthermore, hormonal and histologic measures of luteal adequacy fail to evaluate the numerous peptide and other factors that are essential to ensure the vascular, biochemical, and immunological preparation of the endometrium for successful implantation of the developing embryo. 28,29 Thus, numerous possibilities exist for complete or incomplete errors in the woman as well as the man that could cause infertility that would appear, clinically, to be unexplained.…”