Immunological status of patients in the acute period of ischemic stroke

Abstract

The purpose of this study was to assess immunological status and correlations of cytokines of diff erent groups in patients in the acute period of ischemic stroke (IS). Material and methods. 80 patients with IS (treatment group) and 20 patients with cardiovascular diseases (control group) were examined. All patients were assessed for comorbidity, cognitive function and demographic characteristics. The following were assessed in patients with IS: IS subtype, functional status using Barthel Index (BI), Ranking scale (mRS), National Institutes of Health Stroke Scale (NIHSS), neuroimaging parameters. Laboratory diagnosis included assessment of serum concentrations of interleukins, interferons, CXC- and CC-chemokines, MIF, GM-CSF and TNF-α. Statistical analyses were performed using Python and its libraries Pandas and SciPy. Results. Higher levels of IFN-γ, CXCL1, and CCL23 were determined in patients with IS. CXCL1 was found to correlate with BI, NIHSS, MoCA, foci size; IL — 6 — with BI, NIHSS, presence of diabetes, overweight; IFN-γ — with hyperlipidemia, BI, NIHSS. CCL23 levels were associated with mRS at day 14, presence of atherosclerosis, atherothrombotic subtype of IS; CCL2 — with BI, presence of atherosclerosis, leukoaraiosis, and hypertension; CXCL8 — with MoCA, NIHSS, diabetes. Conclusion. The research of the level and differential expression of cytokines in patients in the acute period of IS is an actual direction of clinical medicine. The verifi cation of cytokines CXCL1, CXCL8, CCL23, CCL2, IL-6 and IFN-γ as potential biomarkers of severity, course and outcomes of AI requires clarifi cation through further studies.