Immunological, structural and stem cell characteristics of subcutaneous (SC) abdominal adipose in lean polycystic ovary syndrome (PCOS) women versus normoandrogenic ovulatory (NL) women

Lean Women with Polycystic Ovary Syndrome

“…Accumulation of small subcutaneous abdominal fat in those patients shows spoiled adipogenesis and hyperandrogenism [53]. Also, abnormal gene expression in stem cell of subcutaneous abdominal fat in normoandrogen and ovulatory lean PCO women display abnormal vacuolization and angiogenesis, which may reflect metabolism alter in those women [54]. From another side, adiponectin, a protein which is involved in regulating glucose levels and fatty acid breakdown, is produced by omental fat and dysregulated by high level of insulin; thus, even in lean PCOs women, inappropriate metabolism of glucose and lipid can be explained [55].…”