Immunological Studies in Nephrotic Syndrome Associated With Extrarenal Malignant Disease

Lewis, Martin; Loughridge, Lavinia W.; Phillips, Terence M.

doi:10.1016/s0140-6736(71)92305-1

Cited by 169 publications

(43 citation statements)

References 12 publications

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“…The identification of antigenis (9-12) anid specific antibody to thenm (9,40), in subepithelial GBMI deposits in memlbranous nephropathy in man is consistenit with the view that these deposits represen-t glomertular trapping of circulatin-ig, soluble immune complexes as apparenitly occurs in the acute and chronic serum sickniess mlodels in rabbits (1,2,41). Immune complexes have been directly visuialized in the circulationi, crossing the GBMI, and localized in the subepithelial space in mice immunized with ferritin by Stilmant et al (42).…”

Section: Resultsmentioning

confidence: 99%

Effect of aminonucleoside nephrosis on immune complex localization in autologous immune complex nephropathy in rats.

Couser¹,

Jermanovich²,

Belok³

et al. 1978

J. Clin. Invest.

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A B S T R A C T The effect of increased capillary perilmealility on1 glomerular immultine comiiplex localizationi was studied in rats immiluniized with proximial tul)ular anitigeni (Fx1A) to induce autologouis imnmunie complex nephropathy (AICN). AICN rats were made proteinuric 1)V-injection or uniilateral renal perfusion with amiiinoinucleoside of puromycin (PA) before developing sul)epithelial conmplex deposits. Control AICN kidneys developed diffuse granular deposits of IgG and Fx1A oIn the subepithelial surf'ace of the glomerular b)asement membrane (GBM) at 3 wk by immuiinofluiorescence and electron microscopy, and dep(isits increased in sul)-se(quienit weekly biopsies. In conitrast, PA-nephrotic AICN kidneys developed few or no GBM deposits and a significant increase in mesangial localization of IgG and FxlA during the period of PA-induced proteinuria. These alterationis in complex localizationi were documenited 1)oth in rats with PA nephrosis andl in unilaterally PA-inephrotic kidneys compared with conitralateral controls in the sanme animiials, thus excluidinig any effect of PA on the imnililiiopatlhogenetic mlechaniisnm in AICN as ani explaniation for these finidings. The absence of GBMi deposits closely correlated with reducedl stainiing for polyanionic glomierilar sialoproteini in proteinutiric kidneys, siniee PA-perfuised kidneys studied 2 wk after resdoltutioin of proteinutria demiion strated retuirni of niormlial staininig for sialoprotein Portionis of this work were presented at the 8th Ainutal

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Section: Resultsmentioning

confidence: 99%

Effect of aminonucleoside nephrosis on immune complex localization in autologous immune complex nephropathy in rats.

Couser¹,

Jermanovich²,

Belok³

et al. 1978

J. Clin. Invest.

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“…Rarely, tumor neoantigens or antitumor antibodies have been localized to the immune deposits seen in MN with cancer (20,21). Patients with malignancy have an increased prevalence of glomerular IgG deposits compared with noncancer patients; however, these deposits are mostly in the subendothelial or mesangial locales, rather than in subepithelium-like sites so typical of idiopathic MN (22).…”

Section: Discussionmentioning

confidence: 99%

Attending Rounds

Glassock

2012

Clinical Journal of the American Society of Nephrology

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SummaryNephrotic syndrome in older adult patients is a common clinical conundrum. Membranous nephropathy (MN) is a lesion frequently found to underlie the nephrotic state in such patients. Determining with reasonable certainty whether the nephrotic syndrome and MN is primary (idiopathic) or due to an underlying disease such as neoplasia can be a daunting clinical challenge. By way of a presentation of an illustrative case and a focused review of the relevant literature, the approach to evaluation of such patients, with an emphasis on the putative causative role of neoplasia in MN, is analyzed and a potential contemporary pathway for acquiring the correct diagnosis is offered.

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“…In a patient with carcinoma of the lung who also developed nephritis, the glomerular lesion contained irregular deposits of IgG, and immunoglobulins eluted from his kidney reacted with an extract of his tumor (14). Glomerulonephritis associated with neoplams is being reported with increasing frequency (15), and it is possible that in these cases the nephritis is due to antigen-antibody complexes formed as the result of an immune response to antigens of the tumor.…”

Section: Discussionmentioning

confidence: 99%

Chronic Allogeneic Disease

Gleichmann

André-Schwartz

et al. 1972

The Journal of Experimental Medicine

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The pathogenesis of glomerulonephritis in F1 hybrid mice injected with parental spleen cells was investigated in several ways. Whenever glomerulonephritis developed, the lesion had the typical morphology produced by antigen-antibody complexes. Experiments employing backcross mice demonstrated that the antigen is supplied by the recipient and that it is specified by the H-2 gene complex, or by a locus closely linked to H-2. The source of the antibody was investigated by staining glomerular lesions with fluorescein isothiocyanate-tagged anti-immunoglobulin allotype sera. Only donor-type allotypes could be detected. The ability of the donor's immunocytes to respond to the recipient's histocompatibility antigens in such a way as to produce nephritogenic immune complexes varied from strain to strain, and seemed to be controlled by a gene unrelated to H-2. The results suggest that cell surface antigens, such as histocompatibility antigens, may be of importance in the pathogenesis of several kinds of glomerulonephritis.

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Immunological Studies in Nephrotic Syndrome Associated With Extrarenal Malignant Disease

Cited by 169 publications

References 12 publications

Effect of aminonucleoside nephrosis on immune complex localization in autologous immune complex nephropathy in rats.

Effect of aminonucleoside nephrosis on immune complex localization in autologous immune complex nephropathy in rats.

Attending Rounds

Chronic Allogeneic Disease

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