Immunological Studies in Patients with Mumps Orchitis

Andrada, J A; Walde, F.; Hoschoian, J.C.; E, Comini; Mancini, Elena

doi:10.1111/j.1439-0272.1977.tb01289.x

Cited by 26 publications

(4 citation statements)

References 15 publications

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“…At 30 days, only one third of the immunised mice showed histological symptoms of EAEO, while at 50 and 80 days all animals immunised with testicular homogenate in CFA and pertussis toxin developed the testicular inflammation characterised by presence of inflammatory infiltrates, disruption of the testicular morphology with a reduction of the diameter of the seminiferous epithelium, sloughing of germ cells and tubular atrophy leading to a smaller testis size. Notably, testicular biopsies from infertile men have been found to contain immunopathologic evidence of focal inflammatory infiltrates and granulomatous orchitis 5 38 . Our findings show that the modified immunisation protocol used in this study leads to a reproducible very high induction rate of EAEO in the C57BL/6N mouse strain (100%) compared to previously described studies in different mouse strains (e.g.…”

Section: Discussionmentioning

confidence: 99%

Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo–orchitis in mice

Nicolas

Michel

Bhushan

et al. 2017

Sci Rep

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Experimental autoimmune epididymo-orchitis (EAEO) is a model of chronic inflammation, induced by immunisation with testicular antigens, which reproduces the pathology of some types of human infertility. Activins A and B regulate spermatogenesis and steroidogenesis, but are also pro-inflammatory, pro-fibrotic cytokines. Expression of the activins and their endogenous antagonists, inhibin and follistatin, was examined in murine EAEO. Adult untreated and adjuvant-treated control mice showed no pathology. All mice immunised with testis antigens developed EAEO by 50 days, characterised by loss of germ cells, immune cell infiltration and fibrosis in the testis, similar to biopsies from human inflamed testis. An increase of total CD45+ leukocytes, comprising CD3+ T cells, CD4 + CD8− and CD4 + CD25+ T cells, and a novel population of CD4 + CD8+ double positive T cells was also detected in EAEO testes. This was accompanied by increased expression of TNF, MCP-1 and IL-10. Activin A and B and follistatin protein levels were elevated in EAEO testes, with peak activin expression during the active phase of the disease, whereas mRNA expression of the inhibin B subunits (Inha and Inhbb) and activin receptor subunits (Acvr1b and Acvr2b) were downregulated. These data suggest that activin–follistatin regulation may play a role during the development of EAEO.

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Section: Discussionmentioning

confidence: 99%

Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo–orchitis in mice

Nicolas

Michel

Bhushan

et al. 2017

Sci Rep

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“…3 ). In early clinical experiments, delayed-type hypersensitivity reactions to sonicates prepared from human spermatozoa could be elicited in patients with mumps orchitis ( Andrada et al , 1977 ). Moreover, immunization with testis homogenate in CFA performed before orchidectomy for treatment of prostate carcinoma led to testicular lesions characteristic of EAO in two of four patients tested ( Mancini et al , 1965 ).…”

Section: Linking Autoimmune Orchitis Models To Human Diseasementioning

confidence: 99%

Infectious, inflammatory and ‘autoimmune’ male factor infertility: how do rodent models inform clinical practice?

Fijak

Pilatz

Hedger

et al. 2018

Human Reproduction Update

218

176

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“…(2)Mumps viruses can attach to the sperm surface,and, serving as haptens,lead to the productionof sperm antibodies. 3The antigenic mimicrybetween the mumps virus and human spermatozoa causes the production of cross-reacting antibodies in the course of the disease.However, the limited experimental and clinicaldata have revealed a contradictory picturewith regard to any of the above hypotheses, andthe results of the few studies available haveremained uncertain (6,7,8,9). None of these investigationshave provided convincing data asto whether mumps orchitis can induce the productionof systemic sperm antibodies.…”

Section: Introduction:-mentioning

confidence: 99%

THE EFFECT OF INFECTION BY MUMPS AFTER PUBERTY ON THE SEMINAL FLUID PARAMETERS AND THE PRODUCTION OFANTIBODIES AGAINSTSPERM IN INFERTILE MALES IN ERBIL CITY, Iraq

Zaki¹,

Kawther²

2016

IJAR

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Background:Mumps is caused by a RNA virus belonging to the myxo virus group. One of its most notorious complications is mumps orchitis. Although it may cause infertility in some of the affected males, the exact mechanisms of fertility impairment are not entirely understood. Mumps viruses can attach to the sperm surface, and, serving as haptens, lead to the production of sperm antibodies. Aims and objectives: 1. To know if there is a relation between the infection by mumps after puberty and the result of seminal fluid analysis. 2. To determine the presence of anti-sperm antibodies(ASAs) in male serum and semen. 3. To know the relation between pumps in puberty and the ASAs in semen and serum of infertile males. Patients and methods:A cross sectional study carried in subfertility care and IVF centre in Erbil city in Iraqi Kurdistan from November 2013-September, 2014. 200 infertile males were included in the study. A semen specimen was collected and analysed for semen parameters, the seminal fluid analysis of semen was classified the seminal fluid to normal and abnormal according to WHO guideline. Serum and semen collected from males for detection of antisperm antibodies by using ElISA (enzyme linked munosorbent assay) used for detection ASAs in the serum of males and also for detection ASAs in male seminal fluid qualitatively. Result:The mean age of infertile male participated in the study was (33.905 year) with maximum and minimum age was (51year, 22 year) respectively, among 200 male the frequency of males with history of mumps after puberty was 26 which represents about 13% of infertile male whom participated in the study. Among 26(13%) of infertile males with history of mumps after puberty 16 infertile which represents about (61.54%) they have abnormal seminal fluid analysis. Anti-spermanti-bodies was positive in the serum of 12(46.15%) males out of 26 males with history of mumps after puberty and Anti sperm antibodies found in the semen of 18(54.55%) males with history of mumps infection after puberty. Conclusions:Mumps can cause infertility in male if they infected after puberty due to the rupture of testis blood barrier and can affect the sperms either by decreasing the count or motility so it can lead to oligozoospermia or asthenozoospermia, mumps also canlead to production of antibodies against sperm and can be detected either in blood or seminal fluid and these

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Immunological Studies in Patients with Mumps Orchitis

Cited by 26 publications

References 15 publications

Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo–orchitis in mice

Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo–orchitis in mice

Infectious, inflammatory and ‘autoimmune’ male factor infertility: how do rodent models inform clinical practice?

THE EFFECT OF INFECTION BY MUMPS AFTER PUBERTY ON THE SEMINAL FLUID PARAMETERS AND THE PRODUCTION OFANTIBODIES AGAINSTSPERM IN INFERTILE MALES IN ERBIL CITY, Iraq

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