Immunological studies of submaxillary saliva from patients with cystic fibrosis and from normal children

Invited Review: Genetics of Human Salivary Proteins

“…Shomers et al (1982a) identified a family of cysteine-containing phosphoproteins and characterized three groups of these proteins. This family of proteins shows the so-called "double component" pattern described previously by immunoelectrophoresis (Ellison, 1966;Masson et al, 1965;Gugler et al, 1968), and most likely includes the phosphoproteins described by Boat et al (1974) and Mayo and Carlson (1974). Juriaanse and Booij (1979a,b) isolated and characterized three acidic and one neutral proteins that also belong to this family and demonstrated their preferential adsorption from saliva onto hydroxyapatite.…”

Host Defenses in Patients with Cystic Fibrosis: Modulation by <i>Pseudomonas aeruginos</i><i>a</i>

“…Both secretory and serum IgA appear to be normal or elevated in older patients with CF [111,112,114,116], but in one study, 17% of CF children less than 10 years old had abnor mally low IgA levels [113]. Another group of investigators proposed a defect in assembly of secretory IgA after finding free secretory piece in CF sputum [117], Local production appears to occur in salivary secretions, meco nium [118] and in the jejunum [119] of pa tients with CF.…”

Cystic fibrosis: a mucosal immunodeficiency syndrome

“…Cystic fibrosis was originally recognized in babies with pancreatic insufficiency who failed to thrive and often succumbed to pulmonary infection in infancy or early childhood 1, 2 . Although there has been enormous progress made in understanding the basic biology of the CFTR chloride channel, it remains enigmatic how CFTR mutations cause enhanced susceptibility to pulmonary infection and how this susceptibility might be prevented.…”