Immunological studies of γδ t cells in a case of large granular lymphocyte (LGL) leukemia: Leukemic γδ+ T cells are resistant to growth stimulation in vitro but respond to interferon-α treatment in vivo

Metzger, Ralf; Heckl-Östreicher, Brigitte; Nerl, Christoph; Schondelmaier, S; Kabelitz, Dieter

doi:10.1016/0145-2126(92)90047-b

Cited by 19 publications

(16 citation statements)

References 14 publications

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“…The partial response of LGLs to antiviral treatment in parallel with the clearance of the virus and the presence of LGLs in two more cases further support this hypothesis. Nevertheless, an antiproliferative effect of interferon alpha on LGLs proliferation cannot be excluded although this effect has been reported only once 49 and the contrary would be expected on a physiologic basis. 50 The variability of clinical histories and responses supports the hypothesis of a multistep viral lymphomagenesis in the case of HCV.…”

Section: Discussionmentioning

confidence: 97%

Response to antiviral treatment in hepatitis C virus-associated marginal zone lymphomas

et al. 2004

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A link between chronic hepatitis C virus (HCV) infection and low-grade B-cell lymphomas has been suggested by epidemiological studies. Marginal zone lymphomas (MZLs) including splenic lymphomas with villous lymphocytes are among the most frequently reported subgroups in the setting of chronic HCV infection. In this study, we examined the effect of antiviral treatment in eight patients with HCV-associated MZL. We found that five out of eight patients have responded to interferon alpha and ribavirin. In some cases, hematologic responses were correlated to virologic responses. In addition, we report a case of large granular lymphocyte leukemia occurring in association with MZL and HCV, and responding to interferon and ribavirin. We suggest that there is an etiologic link between HCV and antigen-driven lymphoproliferative disorders.

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Section: Discussionmentioning

confidence: 97%

Response to antiviral treatment in hepatitis C virus-associated marginal zone lymphomas

et al. 2004

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“…The LGLs are gd T-cells. Clinical and hematologic findings and results of TCR gene rearrangements in several patients, including our patient, with gd T-cell LGL leukemia reported are summarized in Table I [ [12][13][14][15][16][17][18][19]. In these nine patients, a CD3…”

Section: Discussionmentioning

confidence: 99%

γδ T‐cell large granular lymphocyte (LGL) leukemia with spontaneous remission

et al. 2004

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T‐cell large granular lymphocyte (LGL) leukemia is a clonal disorder with an indolent clinical course. In July 1995, a 46‐year‐old Japanese man was admitted to our hospital because his anemia had progressed. He had a white blood cell count of 3.9 × 109/L with 75% lymphocytes, which were intermediate to large and had almost round nuclei and azurophilic granules, and anemia with a red blood cell count (RBC) of 2.69 × 1012/L, hemoglobin (Hb) of 9.5 g/dL, and hematocrit (Hct) of 28.3%. Electron microscopic examination showed that most of the lymphocytes had a parallel tubular array and dense core granules in their cytoplasm. Flow cytometry and Southern blotting of the T‐cell antigen receptor (TCR) genes using the peripheral blood species showed monoclonal proliferation of LGLs with a CD3+, TCRγδ+, CD4−, CD8−, CD16+, CD56−, CD57−, HLA‐DR+ phenotype, and a TCR γ gene rearrangement, respectively, suggesting that the patient was diagnosed as having γδ T‐cell LGL leukemia. He had no symptoms, organomegaly, or skin lesions. About 1.5 years after diagnosis, the anemia gradually improved with disappearance and appearance of a rearranged band in the TCR‐γ gene and TCR‐β gene, respectively. About 7 years after diagnosis, the anemia improved completely with a RBC of 5.01 × 1012/L, Hb of 14.8 g/dL, and Hct of 44.3%, and he was in complete remission without TCR‐β and ‐γ gene rearrangements. He had received no therapy. This is the first report of spontaneous remission of γδ T‐cell LGL leukemia. Am. J. Hematol. 75:168–172, 2004. © 2004 Wiley‐Liss, Inc.

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“…However, the mechanism of action of interferon in this context remains uncertain. IFN is known to inhibit γδ+ T cells, 22 which have been implicated in the gastrointestinal lesions in Behçet's disease, and in addition has antiviral properties, which may be relevant given a possible role for herpes simplex virus in disease. Both of these aetiological factors are discussed below.…”

Section: Ocular Diseasementioning

confidence: 99%