Immunologische Toleranz

Hopf, U.

doi:10.1007/bf01495980

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1972

1977

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Cited by 6 publications

(1 citation statement)

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“…Further progress was achieved by the possibility of pretreatment of patients with deaggregated normal horse IgG in order to induce immunological unresponsiveness against the xenogeneic globulin [12,17,22,47]. Using this application schedule we were able to show that the frequency of side-reac tions due to ALG was reduced significantly [29,32,33].…”

Section: Discussionmentioning

confidence: 99%

Improved Compatibility of ALG Therapy by Application of Aggregate Free Globulin

Ring¹,

Seifert²,

Seiler³

et al. 1976

Int Arch Allergy Immunol

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Horse anti-human lymphocyte globulin (ALG) solutions contain, like human γ-globulin preparations, a varying amount of IgG aggregates, which increase during longer periods of storage. Aggregate formation does not impair the immunosuppressive potency of ALG, as has been shown by prolongation of skin allograft survival time in primates. Deaggregated ALG, which can be obtained by ultracentrifugation at 100,000 g over 2 h, is less immunogenic than aggregate containing ALG. The clinical compatibility of ALG was significantly improved by ultracentrifugal deaggregation.

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Section: Discussionmentioning

confidence: 99%