2007
DOI: 10.1016/j.micinf.2007.04.006
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Immunologically relevant strain polymorphism in the Amastigote Surface Protein 2 of Trypanosoma cruzi

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Cited by 27 publications
(35 citation statements)
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“…In earlier studies we observed that protective immunity, as measured by reduction in the peak parasitemia and delayed mouse mortality, required three doses of plasmid DNA or recombinant protein (6,17,19). To determine whether protective immunity could be elicited by two immunizing doses, we compared different protocols of vaccination using either homologous or heterologous prime-boosting regimens.…”
Section: Resultsmentioning
confidence: 99%
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“…In earlier studies we observed that protective immunity, as measured by reduction in the peak parasitemia and delayed mouse mortality, required three doses of plasmid DNA or recombinant protein (6,17,19). To determine whether protective immunity could be elicited by two immunizing doses, we compared different protocols of vaccination using either homologous or heterologous prime-boosting regimens.…”
Section: Resultsmentioning
confidence: 99%
“…This protocol was an improvement over others described earlier when we used at least three doses of either plasmid DNA or recombinant protein to achieve significant protective immunity (6,17,19,60). The heterologous prime-boost vaccination was more effective than two doses of plasmid DNA or a single dose of recombinant adenovirus.…”
Section: Discussionmentioning
confidence: 96%
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“…Distinct protective ORFs expressed in trypomastigotes were described as encoding, for example, the enzymatic domain of T. cruzi TS (11,21,22,27,37), the trypomastigote surface antigens (16,33,45), or the complement regulatory protein (40). Other protective ORFs encoded amastigote surface protein 1 (ASP-1) or ASP-2 expressed in the intracellular stages of the parasite (2,6,10,24,43).…”
mentioning
confidence: 99%