Immunology of cancer stem cells in solid tumours. A review

Maccalli, Cristina; Volonté, Andrea; Cimminiello, Carolina; Parmiani, Giorgio

doi:10.1016/j.ejca.2013.11.014

Cited by 97 publications

(70 citation statements)

References 88 publications

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“…Sharing many characteristics with normal stem cells, cancer stem cells not only self-renew, but also differentiate into mature cancer cells. In addition, these cancer stem cells are prone to metastasize and to resist drug-induced apoptosis [7-9]. Although only 1-5% of total PDAC cell population is characterized as PCSCs [10], this cell population is enriched after drug treatment.…”

Section: Introductionmentioning

confidence: 99%

Thiol-ene hydrogels as desmoplasia-mimetic matrices for modeling pancreatic cancer cell growth, invasion, and drug resistance

Lin

Korc

et al. 2014

Biomaterials

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The development of pancreatic ductal adenocarcinoma (PDAC) is heavily influenced by local stromal tissues, or desmoplasia. Biomimetic hydrogels capable of mimicking tumor niches are particularly useful for discovering the role of independent matrix cues on cancer cell development. Here, we report a photo-curable and bio-orthogonal thiol-ene (i.e., cross-linked by mutually reactive norbornene and thiol groups via photoinitiation) hydrogel platform for studying the growth, morphogenesis, drug resistance, and cancer stem cell marker expression in PDAC cells cultured in 3D. The hydrogels were prepared from multi-arm poly(ethylene glycol)-norbornene cross-linked with protease sensitive peptide to permit cell-mediated matrix remodeling. Collagen 1 fibrils were incorporated into the covalent network while cytokines (e.g., EGF and TGF-β1) were supplemented in the culture media for controlling cell fate. We found that the presence of collagen 1 enhanced cell proliferation and Yes-associated protein (YAP) translocation to cell nuclei. Cytokines and collagen 1 synergistically up-regulated MT1-MMP expression and induced cell spreading, suggestive of epithelial-mesenchymal transition (EMT) in the encapsulated cells. Furthermore, PDAC cells cultured in 3D developed chemo-resistance even in the absence of collagen 1 and cytokines. This phenotype is likely a consequence of the enrichment of pancreatic cancer stem cells that expressed high levels of CD24, sonic hedgehog (SHH), and vascular endothelial growth factor (VEGF).

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Section: Introductionmentioning

confidence: 99%

Thiol-ene hydrogels as desmoplasia-mimetic matrices for modeling pancreatic cancer cell growth, invasion, and drug resistance

Lin

Korc

et al. 2014

Biomaterials

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“…The inhibition of NK cells is mediated by the inhibitory killer-cell immunoglobulin-like receptors or NKG2A/CD94 that recognize classical or nonclassical HLA class I molecules, respectively, which are often lost or reduced in malignant cells [13,14]. Contrarily to conventional chemotherapy, NK cells appear to recognize and kill undifferentiated stem-like cells [15,16] by virtue of their ability to target non-dividing cells and due to the low expression of MHC class I molecules and possible up-regulation of stress-induced activation ligands [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells

Ferreira-Teixeira¹,

Parada²,

Paiva-Oliveira³

et al. 2017

European Urology Supplements

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Background: High-grade non-muscle invasive bladder cancer (NMIBC) has a high risk of recurrence and progression to muscle-invasive forms, which seems to be largely related to the presence of tumorigenic stem-like cell populations that are refractory to conventional therapies. Here, we evaluated the therapeutic potential of Natural Killer (NK) cell-based adoptive immunotherapy against chemoresistant bladder cancer stem-like cells (CSCs) in a pre-clinical relevant model, using NK cells from healthy donors and NMIBC patients.

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“…CSCs also express CD200 (106), a molecule that inhibits myeloid cells and could therefore play a major role in tumor immune escape (107, 108). Immunological properties of CSCs in solid tumors have also been recently reviewed by Maccalli et al (109). …”

Section: Immunological Properties Of Cscsmentioning

confidence: 98%

Cancer Stem Cell Immunology: Key to Understanding Tumorigenesis and Tumor Immune Escape?

2014

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Cancer stem cell (CSC) biology and tumor immunology have shaped our understanding of tumorigenesis. However, we still do not fully understand why tumors can be contained but not eliminated by the immune system and whether rare CSCs are required for tumor propagation.Long latency or recurrence periods have been described for most tumors. Conceptually, this requires a subset of malignant cells which is capable of initiating tumors, but is neither eliminated by immune cells nor able to grow straight into overt tumors. These criteria would be fulfilled by CSCs. Stem cells are pluripotent, immune-privileged, and long-living, but depend on specialized niches. Thus, latent tumors may be maintained by a niche-constrained reservoir of long-living CSCs that are exempt from immunosurveillance while niche-independent and more immunogenic daughter cells are constantly eliminated.The small subpopulation of CSCs is often held responsible for tumor initiation, metastasis, and recurrence. Experimentally, this hypothesis was supported by the observation that only this subset can propagate tumors in non-obese diabetic/scid mice, which lack T and B cells. Yet, the concept was challenged when an unexpectedly large proportion of melanoma cells were found to be capable of seeding complex tumors in mice which further lack NK cells. Moreover, the link between stem cell-like properties and tumorigenicity was not sustained in these highly immunodeficient animals. In humans, however, tumor-propagating cells must also escape from immune-mediated destruction. The ability to persist and to initiate neoplastic growth in the presence of immunosurveillance – which would be lost in a maximally immunodeficient animal model – could hence be a decisive criterion for CSCs.Consequently, integrating scientific insight from stem cell biology and tumor immunology to build a new concept of “CSC immunology” may help to reconcile the outlined contradictions and to improve our understanding of tumorigenesis.

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Immunology of cancer stem cells in solid tumours. A review

Cited by 97 publications

References 88 publications

Thiol-ene hydrogels as desmoplasia-mimetic matrices for modeling pancreatic cancer cell growth, invasion, and drug resistance

Thiol-ene hydrogels as desmoplasia-mimetic matrices for modeling pancreatic cancer cell growth, invasion, and drug resistance

Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells

Cancer Stem Cell Immunology: Key to Understanding Tumorigenesis and Tumor Immune Escape?

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