Immunology of Enteric Pathogens Salmonella, Shigella, and Escherichia coli

Levine, Myron M.; Hornick, Richard B.

doi:10.1007/978-1-4684-1009-9_11

Cited by 6 publications

(1 citation statement)

References 314 publications

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“…Conventional killed Salmonella vaccines do not induce maximal protection and cause undesirable side reactions. Conversely, live attenuated Salmonella strains provide better protection than killed vaccines and elicit cell-mediated immunity as well as humoral responses [2]. Moreover, live attenuated Salmonella can be used as a carrier or in combined vaccines to express recombinant antigen from other pathogens [3].…”

Section: Introductionmentioning

confidence: 99%

Differential persistence, immunogenicity and protective capacity of temperature-sensitive mutants ofSalmonella enteritidisafter oral or intragastric administration to mice

Gherardi

García

Brizzio

et al. 1993

FEMS Immunology &Amp; Medical Microbiology

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The persistence of Salmonella enteritidis temperature‐sensitive (ts) mutants of different phenotypes in Peyer's patches (PP) and the spleen, and their immunogenicity after intragastric (i.g.) and peroral (p.o.) administration to mice was investigated. After p.o. administration the ts mutant C/2/2 colonized PP, but was not recovered from the spleen. After i.g. administration the ts mutant E/1/3 colonized both the spleen and PP. for at least 2 weeks. Mutant C/2/2 persisted in PP up to 8 days but was not found in the spleen. Mutant H/2/26, although it poorly colonized the PP, was recovered from the spleen up to day 15 after i.g. administration. Immunization with E/1/3 by either the i.g. or the p.o. routes protected mice from challenge with 100 LD50 of the virulent wild‐type (wt) strain. Immunization with either C/2/2 or H/2/26 did not confer protection. The three ts mutants induced the production of local IgA after i.g. administration regardless of their protective capacity.

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Section: Introductionmentioning

confidence: 99%

Differential persistence, immunogenicity and protective capacity of temperature-sensitive mutants ofSalmonella enteritidisafter oral or intragastric administration to mice

Gherardi

García

Brizzio

et al. 1993

FEMS Immunology &Amp; Medical Microbiology

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Malnutrition is a determining factor in diarrheal duration, but not incidence, among young children in a longitudinal study in rural Bangladesh

Black

Brown

Becker

1984

The American Journal of Clinical Nutrition

222

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Diarrhea and malnutrition are common in young children in developing countries and a reciprocal relationship has been postulated with diarrhea leading to malnutrition and malnutrition predisposing to diarrhea. To investigate the importance of malnutrition as a determining factor in diarrheal illnesses, data were analyzed from a longitudinal community-based study done in rural Bangladesh. Children classified by nutritional status according to a variety of anthropometric indicators were prospectively evaluated for incidence, duration, and etiology of diarrhea. Children with low weight for length had longer durations of diarrhea than better nourished children; however, children of differing nutritional status had similar diarrheal incidences. The duration of diarrhea, including that associated with enterotoxigenic Escherichia coli and Shigella, increased progressively as nutritional status indicators worsened. These results suggest that nutritional interventions alone are unlikely to reduce the high incidence of diarrhea, but that efforts to improve nutritional status may have a beneficial effect on the duration of diarrhea and its unfavorable nutritional consequences.

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Mechanism of the Protective Action of Anti-Salmonella IgM in Experimental Mouse Salmonellosis

Saxén

1984

Microbiology

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Immunology of Enteric Pathogens Salmonella, Shigella, and Escherichia coli

Cited by 6 publications

References 314 publications

Differential persistence, immunogenicity and protective capacity of temperature-sensitive mutants ofSalmonella enteritidisafter oral or intragastric administration to mice

Differential persistence, immunogenicity and protective capacity of temperature-sensitive mutants ofSalmonella enteritidisafter oral or intragastric administration to mice

Malnutrition is a determining factor in diarrheal duration, but not incidence, among young children in a longitudinal study in rural Bangladesh

Mechanism of the Protective Action of Anti-Salmonella IgM in Experimental Mouse Salmonellosis

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