Immunology of Parasitic Helminth Infections

MacDonald, Andrew S.; Araújo, Maria Ilma; Pearce, Edward J.

doi:10.1128/iai.70.2.427-433.2002

Cited by 172 publications

(126 citation statements)

References 102 publications

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“…Our results suggest that in T cell-mast cell communication both the mast cell-derived cytokines and cell-tocell contact are crucial to induce sufficient immune responses, as we showed that the inhibition of cytokine secretion and cell surface molecule upregulation by FhTeg both impaired the mast cells' ability to prime T cells. Our study supports previous findings demonstrating that FhTeg can suppress Th1 immunity in vivo by directly rendering innate immune cells, such as dendritic cells, hyporesponsive to TLR activation (25), a characteristic of helminth-activated dendritic cells (37).…”

Section: Discussionsupporting

confidence: 80%

Fasciola hepatica Tegumental Coat Impairs Mast Cells’ Ability To Drive Th1 Immune Responses

Vukman

Adams

Metz

et al. 2013

The Journal of Immunology

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The parasitic worm Fasciola hepatica induces strong Th2 and T-regulatory immune responses while simultaneously suppressing Th1-driven immune responses to bystander microbial infections. It also prevents the initiation of Th1-mediated autoimmune disorders in mice through the suppression of Th17 and Th1 immune responses, and this can be mimicked by parasite-derived molecules. We have isolated F. hepatica tegumental coat Ag (FhTeg) and demonstrated its suppressive effect in vivo by directly targeting dendritic cells, impairing their ability to drive Th1 responses. Mast cells are critical in promoting Th1 protective immunity during bacterial infection and in driving Th1-mediated pathological conditions in autoimmune diseases. In this article, we show that FhTeg inhibits the ability of mast cells to drive the Th1 immune response by suppressing cytokine secretion (TNF-α, IL-6, IFN-γ, and IL-10) and ICAM1 expression in mast cells stimulated with LPS or heat-inactivated Bordetella pertussis Ag. These heat-inactivated B. pertussis Ag/LPS–stimulated mast cells fail to promote Th1 immune responses in CD4+ T cells when pretreated with FhTeg, and a role for ICAM1 in this process was demonstrated. FhTeg suppresses the activation of transcription factors in the TLR signaling pathway, which explains the decrease in cytokine production and cell surface marker expression. We demonstrated that FhTeg suppresses MAPK and NF-κB activation and enhances SOCS3 expression, which could explain its negative effect on the TLR pathways. We conclude that FhTeg targets innate immune cells, inhibiting their ability to drive Th1 immune responses.

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Section: Discussionsupporting

confidence: 80%

Fasciola hepatica Tegumental Coat Impairs Mast Cells’ Ability To Drive Th1 Immune Responses

Vukman

Adams

Metz

et al. 2013

The Journal of Immunology

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“…These organisms can be micro-cellular (virus, bacterial and fungal) ormacro-cellular (helminths) 7 . Many helminth parasites are long-lived and cause chronic infections 8,9 . Chronic helminth infestation was reported to cause immune dysregulations, characterized by a dominant Th2 type of cytokine immune response (predominantly IL-4 and IL-5, IL-10), a high IgE levels, eosinophilia, low CD4+ and a high CD8+ cells count 10,11,12 .…”

mentioning

confidence: 99%

Effect of Helminth Infestationin Children Infected with Human Immunodeficiency Virus (HIV)

Orji

Onyire

Ibe

et al. 2017

J. Nepal Paedtr. Soc.

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“…Sel T dapat berfungsi untuk merekrut dan mengaktivasi sel-sel efektor, yang sama pada reaksi alergi. 1,2,19,20 Antigen parasit menginduksi antibodi IgE antiparasit. Sel mast mengalami degranulasi saat antibodi IgE berada pada permukaannya untuk berinteraksi dengan antigen.…”

Section: Infeksi Cacingunclassified

“…Umumnya, pemikiran bahwa tingginya eosinofil dalam darah merupakan refleksi dari kepadatan cacing. 1,2,19,20 Untuk penyebarannya, cacing membutuhkan hospes yaitu manusia. Morbiditas hospes sangat tergantung pada kepadatan parasit.…”

Section: Infeksi Cacingunclassified

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Hubungan antara Infeksi Cacing dan Alergi

Yolazenia¹,

Supali²,

Wibowo³

2017

JIK

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Many researches showing the evidence of a reverse relation between helminthiasis and allergic diseases in tropical developing countries, supported by hygiene hypothesis. There is relationship between the inflammation caused by allergic and helminthiasis. Both, allergic and helminthiasis, show the increase of IgE level, eosinophilia, mastocytosis, and release of IL-4, IL-5 and IL-13 cytokines by Th2. Several mechanisms explaining the decrease of allergic manifestation in people with helminthiasis are polyclonal IgE blocking, suppression of anti-inflammatory cytokines (IL-10 and TGF-â), and IgG4 blocking antibody.

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Immunology of Parasitic Helminth Infections

Cited by 172 publications

References 102 publications

Fasciola hepatica Tegumental Coat Impairs Mast Cells’ Ability To Drive Th1 Immune Responses

Fasciola hepatica Tegumental Coat Impairs Mast Cells’ Ability To Drive Th1 Immune Responses

Effect of Helminth Infestationin Children Infected with Human Immunodeficiency Virus (HIV)

Hubungan antara Infeksi Cacing dan Alergi

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