Immunology of Surface Fungi Dermatophytes

Grappel, Sarah F.

doi:10.1007/978-1-4684-1009-9_20

Cited by 4 publications

(5 citation statements)

References 194 publications

(190 reference statements)

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Section: Discussionmentioning

confidence: 99%

“…The immune response dermatophytic infections has been investigated since the beginning of the century (2,3). Inflammatory, deep trichophytic infections are associated.with an intense cell-mediated immune response, which is generally considered to be the principal immunological reaction to these infections (2,3,4). Furthermore, several authors (2,3,5,7) have demonstrated the concomitant presence of specific humoral antibodies, whose biological significance is still partly obscure.…”

Section: Discussionmentioning

confidence: 99%

“…Inflammatory, deep trichophytic infections are associated.with an intense cell-mediated immune response, which is generally considered to be the principal immunological reaction to these infections (2,3,4). Furthermore, several authors (2,3,5,7) have demonstrated the concomitant presence of specific humoral antibodies, whose biological significance is still partly obscure. However, there are no data in the literature regarding the specific immunity long-term after healing of KC.…”

Section: Discussionmentioning

confidence: 99%

“…Although the immune response to this dermatophytosis has been studied by many authors (2,3,4,5,7,8), no follow-up examinations are available concerning either the antibody pattern or the delayed hypersensitivity after healing. To investigate the immunological memory against the responsible mycetes, we investigated the circulating antibodies and the delayed hypersensitivity to trichophytin in a group of subjects who had been affected by trichophytic KC during the last 10 years.…”

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confidence: 99%

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Clinical and Immunological Follow‐Up of Trichophytic Kerion Celsi

Papini

Simonetti

1987

Mycoses

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Summary: Eighteen patients who had been affected by trichophytic Kerion Celsi within the past 10 years, and 18 control subjects, were investigated for immunofluorescent specific antibodies directed against the responsible mycetes and trichophytin skin reactivity. Significant titers of humoral antibodies and intensely positive skin reactions were observed in subjects whose infection pre‐dated the study by 1–5 years. The persistence of specific immunological memory could be a contributing factor to resistance to relapses in these patients. Zusammenfassung 18 Patienten, die innerhalb der letzten 10 Jahre an einem Trichophytonbedingten Kerion Celsi gelitten hatten und 18 Kontrollpersonen wurden auf spezifische Antikörper gegen die verantwortlichen Myzeten mit der Immunfluoreszenz und auf die Trichophytin‐Hautreaktivität untersucht. Deutlich erhöhte Titerwerte der humoralen Antikörper und deutlich positive Hautreaktionen wurden bei Personen beobachtet, deren Infektion 1–5 Jahre zurücklag. Das Bestehen eines spezifischen immunologischen Gedächtnisses könnte zu der Resistenz solcher Patienten gegen Rückfälle beitragen.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Clinical and Immunological Follow‐Up of Trichophytic Kerion Celsi

Papini

Simonetti

1987

Mycoses

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“…Dermatophyten können in den toten keratinisierten Anteilen der Haut und deren Anhangsgebilden parasitieren [4,14]. Gelangen sie jedoch ins Gewebe, so geben die vermehrungsfähigen Dermatophyten Enzyme und Antigene in ihre Umgebung ab, die letztlich die Entzündungsreaktion im Verlauf der Dermatophytose bestimmen [5,13]. Dabei scheinen zelluläre Abwehrmechanismen für die Heilung einer Dermatophytose und die Ausbildung einer erworbenen Immunität von entscheidender Bedeutung zu sein.…”

Section: Klinikunclassified