Immunology of Syphilis

Cannefax, George R.; Norins, Leslie C.; Gillespie, Eugene J.

doi:10.1146/annurev.me.18.020167.002351

Cited by 12 publications

(2 citation statements)

References 24 publications

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“…More interesting are those directed toward determinants found in normal host tissues: the antibody to Wassermann antigen and the Donath-Landsteiner antibody. 20 The Wassermann antigen is a cardiolipid which occurs in the mitochondria of many mammalian tissues. Classically, antibody to it will react with alcoholic extracts of human liver or heart.…”

Section: Immunologic Consequences Of Individual Microbial Agentsmentioning

confidence: 99%

The Immunologic Consequences of Infection

Caldwell

1971

Postgraduate Medicine

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Section: Immunologic Consequences Of Individual Microbial Agentsmentioning

confidence: 99%

The Immunologic Consequences of Infection

Caldwell

1971

Postgraduate Medicine

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“…Infection with the spirochete Treponema pallidum subsp. pallidum, the etiological agent of syphilis, produces at least two types of antibodies within the human host: treponemal antibodies, which react with T. pallidum and other pathogenic treponemes, and nontreponemal antibodies (reagin), which react with cardiolipin, cholesterol, and lecithin antigen mixtures (1). The Venereal Disease Research Laboratory (VDRL) and the rapid plasma reagin (RPR) antigen slide tests were originally developed to detect reaginic antibodies in these individuals (10).…”

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confidence: 99%

Capture-S, a nontreponemal solid-phase erythrocyte adherence assay for serological detection of syphilis

et al. 1997

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A solid-phase erythrocyte adherence assay has been developed for the serological detection of reagin antibodies in syphilis. CaptureS (Immucor, Inc., Norcross, Ga.) is a nontreponemal, qualitative screening test for the detection of immunoglobulin G (IgG) and IgM antilipid antibodies in serum or plasma samples from blood donors. The CaptureS assay utilizes a modified Venereal Disease Research Laboratory antigen bound to microtitration wells and anti-IgG-plus anti-IgM-coated indicator erythrocytes as the detection system. The CaptureS assay was evaluated at six separate sites on 10,942 specimens. For patient samples of clinically diagnosed syphilis categories (n ‫؍‬ 366), the CaptureS assay yielded a sensitivity of 80.7% versus 80.3% for the rapid plasma reagin (RPR) card test (Becton Dickinson Microbiology Systems, Cockeysville, Md.). In comparative experiments on patient and donor samples (n ‫؍‬ 10,222), the CaptureS assay demonstrated a sensitivity of 94% compared to 91.2% for the RPR card test. The CaptureS and RPR card tests produced essentially equivalent specificities of 99.2% and 99.3%, respectively, for this sample population. For five test sites, the CaptureS and RPR card test demonstrated a 98.3% agreement (10,085 of 10,264) of test results. These evaluations indicate that the CaptureS compares favorably to the RPR card test in assay sensitivity and specificity, with the added benefits of ease of use, accommodation of high-volume testing, and potential for automation.

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Human treponematosis and tuberculosis: Evidence from the New World

El-Najjar

1979

American J Phys Anthropol

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The purpose of this study has been first, to critically review the evidence for the presence of human treponematosis and tuberculosis in the skeletal remains of prehistoric natives in the New World, and second, to report on nine new cases dated to before contact and suggesting the presence of these two disease conditions. A review of the medical history and findings by human paleopathologists leaves little doubt that both diseases originated in the Old World. The findings of this study lend further support to the fact that, although rare, human treponematosis and tuberculosis were indeed endemic in the pre-Columbia New World before contact. There is no evidence that these two diseases could have arisen independently and de novo, especially during the relatively short time since man's arrival in the New World. Where a disease has been endemic for quite some time as appears to be the case with human treponematosis and tuberculosis, milder forms of the disease and improved host response could have developed in which only the most severe cases would be observable. This explains the rarity of skeletal lesions suggestive of these two human disease conditions in prehistoric human populations.

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Immunology of Syphilis

Cited by 12 publications

References 24 publications

The Immunologic Consequences of Infection

The Immunologic Consequences of Infection

Capture-S, a nontreponemal solid-phase erythrocyte adherence assay for serological detection of syphilis

Human treponematosis and tuberculosis: Evidence from the New World

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