Immunology of the Antibiotics

Antibodies against the benzylpenicilloyl moiety as a probe for penicillin-binding proteins

“…For several reasons, we believe that the PBPbound p-lactam moiety which reacted with the antiserum is the penicilloyl group. BPO has been shown by many laboratories to be the main determinant when BPO conjugates are used as the antigen [16]. The antibodies used in our experiments reacted also with B P O -( L~S )~~ and bound penicilloic acid better than intact penicillin.…”

Penicillin Hypersensitivity — Is Milk a Significant Hazard?: A Review

“…The role of tetracyclines and aminoglycosides in inducing allergic reactions has been reviewed (Dewdney 1977). These antibiotics can participate in immunologically-mediated reactions but it is unlikely that their presence in milk could, as a consequence, be a clinical hazard.…”

“…These too are ,B-lactam-containing antibiotics and share with the penicillins protein reactivity through the P-lactam carbonyl §-CH2. CO An earlier review addresses a number of these immunochemical points (Dewdney 1977). Within this general framework, routes to the formation of penicillin-related allergens, consequent upon the use of intramammary penicillin preparations to control bovine mastitis, can be defined.…”

“…A further source of preformed allergens to be considered are the dimers, oligomers and polymers (see Dewdney 1977). It has been shown that penicillins can polymerize in solution and routes to the formation of polymers, and their structures, have been described.…”

Allergic and immunological aspects of therapy with cefotaxime and other cephalosporins

“…Indeed, aminolysis rate among penicillins is variable and seems to correlate to some extent with the capacity to sensitize rodents. While the reactivity of penicillins to form the major penicilloyl antigenic determinant is well known, the corresponding immunochemistry of cephalosporins is more complex and has been less extensively studied (Dewdney, 1977). Studies on the chemical reactivity of cephalosporins with amines or proteins at various pH have suggested that cephalosporoyl amide, the equivalent of the penicilloyl haptenic group is of low stability and may decompose to more simple, e.g.…”