Immunomodulating action of the 3-phenylcoumarin derivative 6,7-dihydroxy-3-[3′,4′-methylenedioxyphenyl]-coumarin in neutrophils from patients with rheumatoid arthritis and in rats with acute joint inflammation

Albiero, Lucinéia Reuse; Andrade, Micássio Fernandes de; Marchi, Larissa Fávaro; Landi-Librandi, Ana Paula; Figueiredo-Rinhel, Andréa S.G.; Carvalho, Camila Andressa; Kabeya, Luciana M.; Oliveira, Renê Donizeti Ribeiro de; Azzolini, Ana Elisa Caleiro Seixas; Pupo, Mônica Tallarico; Emery, Flávio da Silva; Lucisano-Valim, Yara Maria

doi:10.1007/s00011-019-01298-w

Cited by 10 publications

(4 citation statements)

References 51 publications

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“…When applied to immune complex-stimulated neutrophils from healthy human and RA patients, the loaded liposomes not only suppressed the release of neutrophil extracellular traps and chemotaxis in vitro, but also avoided evident toxicity. When applied to rats with zymosan-induced arthritis, the liposomes significantly reduced joint edema and leukocyte infiltration at a low dose (1.5 mg/kg), which was 2.6-fold lower than the dose of DEX as positive control [65].…”

Section: Soy Lecithinmentioning

confidence: 84%

Food-Derived Nanoscopic Drug Delivery Systems for Treatment of Rheumatoid Arthritis

Han

Chen

2020

Molecules

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Rheumatoid arthritis (RA) is a severe systemic inflammatory disease with no cure at present. Recent developments in the understanding of inflammation and nanomaterial science have led to increased applications of nanostructured drug delivery systems in the treatment of RA. The present review summarizes novel fabrications of nanoscale drug carriers using food components as either the delivered drugs or carrier structures, in order to achieve safe, effective and convenient drug administration. Polyphenols and flavonoids are among the most frequently carried anti-RA therapeutics in the nanosystems. Fatty substances, polysaccharides, and peptides/proteins can function as structuring agents of the nanocarriers. Frequently used nanostructures include nanoemulsions, nanocapsules, liposomes, and various nanoparticles. Using these nanostructures has improved drug solubility, absorption, biodistribution, stability, targeted accumulation, and release. Joint vectorization, i.e., using a combination of bioactive molecules, can bring elevated therapeutic outcomes. Utilization of anti-arthritic chemicals that can self-assemble into nanostructures is a promising research orientation in this field.

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Section: Soy Lecithinmentioning

confidence: 84%

Food-Derived Nanoscopic Drug Delivery Systems for Treatment of Rheumatoid Arthritis

Han

Chen

2020

Molecules

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“…3-phenylcoumarins bearing aminoalkoxy moiety has been designed to treat Alzheimer’s disease by inhibiting acetylcholinesterase and butyrylcholinesterase [ 51 ]. 3-phenylcoumarins with dihydroxyl substituents in the coumarin core have been studied for antioxidative effect [ 52 , 53 ]. Radioiodinated 3-phenylcoumarins have been evaluated targeting myelin in multiple sclerosis [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Coumarins as Tool Compounds to Aid the Discovery of Selective Function Modulators of Steroid Hormone Binding Proteins

Niinivehmas

Pentikäinen

2021

Molecules

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Steroid hormones play an essential role in a wide variety of actions in the body, such as in metabolism, inflammation, initiating and maintaining sexual differentiation and reproduction, immune functions, and stress response. Androgen, aromatase, and sulfatase pathway enzymes and nuclear receptors are responsible for steroid biosynthesis and sensing steroid hormones. Changes in steroid homeostasis are associated with many endocrine diseases. Thus, the discovery and development of novel drug candidates require a detailed understanding of the small molecule structure–activity relationship with enzymes and receptors participating in steroid hormone synthesis, signaling, and metabolism. Here, we show that simple coumarin derivatives can be employed to build cost-efficiently a set of molecules that derive essential features that enable easy discovery of selective and high-affinity molecules to target proteins. In addition, these compounds are also potent tool molecules to study the metabolism of any small molecule.

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“…The bee derived 5,7-dihydroxy-6-(3-methylbutanoyl)-8-(3-methylbut-2-enyl)-4-phenylchromen-2-one effectively reduced the proliferation of Th-17 leucocytes in vitro and reduced the inflammatory response in an autoimmune mouse model [59]. In a rat model of rheumatoid arthritis, 6,7-dihydroxy-3-[3′,4′-methylenedioxyphenyl]-coumarin reduced the neutrophilic infiltration of the synovial fluids in the affected joints [60]. The simple coumarins 7,8-dihydroxychromen-2-one and 3-(4-aminophenyl)-coumarin showed significant improvement of collagen induced rheumatoid arthritis in rats [61,62].…”

Section: Coumarins With Potential Immunosuppressive Effectsmentioning

confidence: 97%

Coumarins and their Derivatives as Potential Modulators of Immune Response

Bipat

2024

Adv Res Sci

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Coumarins are molecules varying from simple to more complex compounds that are widely available in nature, while some of them have been synthesized. They possess significant pharmacological potential, but until now their applicability in medicine has been limited to their ability to limit coagulation in blood. Our immune system plays a major role in disease states, with both ends of the spectrum being significant. Both a slow or absent immune reaction on one hand and an overreaction of the system on the other hand may be detrimental to our health. Since the process of coagulation seems to be related to the immune system, studies showing a possible role for coumarins and their lead compounds in modulating the immune system. were searched for in databases like PubMed, Google Scholar and Hinari. Several studies with promising results revealing a role for coumarins in modulating the immune response, were found However, all these studies have been carried out in in vitro and simple animal models. Randomized clinical trials will be required to demonstrate the therapeutic value of these readily available coumarin compounds.

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Immunomodulating action of the 3-phenylcoumarin derivative 6,7-dihydroxy-3-[3′,4′-methylenedioxyphenyl]-coumarin in neutrophils from patients with rheumatoid arthritis and in rats with acute joint inflammation

Cited by 10 publications

References 51 publications

Food-Derived Nanoscopic Drug Delivery Systems for Treatment of Rheumatoid Arthritis

Food-Derived Nanoscopic Drug Delivery Systems for Treatment of Rheumatoid Arthritis

Coumarins as Tool Compounds to Aid the Discovery of Selective Function Modulators of Steroid Hormone Binding Proteins

Coumarins and their Derivatives as Potential Modulators of Immune Response

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