Immunomodulating Hydrogels as Stealth Platform for Drug Delivery Applications

Abstract

Non-targeted persistent immune activation or suppression by different drug delivery platforms can cause adverse and chronic physiological effects including cancer and arthritis. Therefore, non-toxic materials that do not trigger an immunogenic response during delivery are crucial for safe and effective in vivo treatment. Hydrogels are excellent candidates that can be engineered to control immune responses by modulating biomolecule release/adsorption, improving regeneration of lymphoid tissues, and enhancing function during antigen presentation. This review discusses the aspects of hydrogel-based systems used as drug delivery platforms for various diseases. A detailed investigation on different immunomodulation strategies for various delivery options and deliberate upon the outlook of such drug delivery platforms are conducted.

The Application of Biomaterials for the Vaccine, Treatment, and Detection of SARS-CoV-2

“…In addition to their use as adjuvants and delivery vehicles for COVID-19 vaccines, biomaterials themselves have antiviral properties and could be used as carriers for delivering drugs . These antiviral biomaterials could be applied for the treatment of SARS-CoV-2.…”

“…In addition to their use as adjuvants and delivery vehicles for COVID-19 vaccines, biomaterials themselves have antiviral properties and could be used as carriers for delivering drugs. 160 These antiviral biomaterials could be applied for the treatment of SARS-CoV-2. Furthermore, while many anti-SRAS-CoV-2 agents have been approved by the WHO, their efficacy has been limited by adverse side effects.…”

Immunomodulatory hydrogels for skin wound healing: cellular targets and design strategy

“…In addition to the intrinsic properties of hydrogels, their ability to deliver active constituents is another strategy for immunomodulation of skin wound healing. 159 Different types of delivery hydrogels are developed based on immunoregulatory cellular targets. They act as a cargo of diverse components, such as metal ions/nanoparticles, exosomes, cytokines, growth factors, miRNA, synthetic bioactive molecules, stem cells, and oxygen, which regulate the immune response to achieve better healing results.…”

Current Advances in Immunomodulatory Biomaterials for Cell Therapy and Tissue Engineering

“…This illustrates the features of hydrogel‐based medication delivery systems. [ 32 ] Research establishing the relevance of lymphatic tissues in the response to immunotherapy has renewed interest in the use of customized drug delivery systems (DDSs) to enable precise targeting of immunomodulators to lymphatic tissues and the cells they house. [ 33 ]…”