Immunomodulation-based development engineering for advancing metal soft tissue implants

Chen, Shoucheng; Shi, Jiamin; Gao, Guangqi; Xie, Lv; Zhang, Yingye; Shan, Zhengjie; Huang, Zhuwei; Zhang, Xinchun; Chen, Zhuofan; Chen, Zetao

doi:10.1016/j.smaim.2023.04.005

Cited by 11 publications

(2 citation statements)

References 152 publications

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“…Therefore, macrophage polarization by immunomodulation strategies is necessary to convert pro-inflammatory M1 to reparative M2 phenotype, which is essential for faster peri-implant epithelial and connective tissue formation. 101 Further unlike osseointegration, soft tissue attachment is a mechanically inferior physical adaptation of mucosal/skin tissues to metallic prostheses and not a case of biological integration. Therefore, while the problem of metallic implant osseointegration has been nearly solved by Ti and its surface modifications, soft tissue integration/attachment to percutaneous bone-anchored prostheses is a perennial problem that remains unaddressed (Figure 4).…”

Section: Soft Tissuementioning

confidence: 99%

“…Such prolonged healing periods arise from chronic inflammation and provide sufficient time for bacterial ingress and colonization. Therefore, macrophage polarization by immunomodulation strategies is necessary to convert pro-inflammatory M1 to reparative M2 phenotype, which is essential for faster peri-implant epithelial and connective tissue formation . Further unlike osseointegration, soft tissue attachment is a mechanically inferior physical adaptation of mucosal/skin tissues to metallic prostheses and not a case of biological integration.…”

Section: Hard and Soft Tissue Integration Around Percutaneous Bone-an...mentioning

confidence: 99%

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Soft and Hard Tissue Integration around Percutaneous Bone-Anchored Titanium Prostheses: Toward Achieving Holistic Biointegration

Shrivas,

Samaur,

Yadav

et al. 2024

ACS Biomater. Sci. Eng.

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A holistic biointegration of percutaneous boneanchored metallic prostheses with both hard and soft tissues dictates their longevity in the human body. While titanium (Ti) has nearly solved osseointegration, soft tissue integration of percutaneous metallic prostheses is a perennial problem. Unlike the firm soft tissue sealing in biological percutaneous structures (fingernails and teeth), foreign body response of the skin to titanium (Ti) leads to inflammation, epidermal downgrowth and inferior peri-implant soft tissue sealing. This review discusses various implant surface treatments/texturing and coatings for osseointegration, soft tissue integration, and against bacterial attachment. While surface microroughness by SLA (sandblasting with large grit and acid etched) and porous calcium phosphate (CaP) coatings improve Ti osseointegration, smooth and textured titania nanopores, nanotubes, microgrooves, and biomolecular coatings encourage soft tissue attachment. However, the inferior peri-implant soft tissue sealing compared to natural teeth can lead to peri-implantitis. Toward this end, the application of smart multifunctional bioadhesives with strong adhesion to soft tissues, mechanical resilience, durability, antibacterial, and immunomodulatory properties for soft tissue attachment to metallic prostheses is proposed.

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Section: Soft Tissuementioning

confidence: 99%

Section: Hard and Soft Tissue Integration Around Percutaneous Bone-an...mentioning

confidence: 99%

Soft and Hard Tissue Integration around Percutaneous Bone-Anchored Titanium Prostheses: Toward Achieving Holistic Biointegration

Shrivas,

Samaur,

Yadav

et al. 2024

ACS Biomater. Sci. Eng.

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Development of Zinc-Containing Chitosan/Gelatin Coatings with Immunomodulatory Effect for Soft Tissue Sealing around Dental Implants

Han,

Sanders,

Andrée

et al. 2024

Tissue Eng Regen Med

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BACKGROUND: Soft tissue integration (STI) around dental implant abutments is a prerequisite to prevent bacterial invasion and achieve successful dental implant rehabilitation. However, peri-implant STI is a major challenge after dental abutment placement due to alterations in the immune microenvironment upon surgical dental implant installation. METHODS: Based on known immunomodulatory effects of zinc, we herein deposited zinc/chitosan/gelatin (Zn/CS/Gel) coatings onto titanium substrates to study their effect on macrophages. First, we exposed macrophages to cell culture media containing different zinc ion (Zn2+) concentrations. Next, we explored the immunomodulatory effect of Zn/CS/Gel coatings prepared via facile electrophoretic deposition (EPD). RESULTS: We found that Zn2+ effectively altered the secretome by reducing the secretion of pro-inflammatory and enhancing pro-regenerative cytokine secretion, particularly at a Zn2+ supplementation of approximately 37.5 μM. Zn/CS/Gel coatings released Zn2+ in a concentration range which effectively stimulated pro-regenerative macrophage polarization as demonstrated by M2 macrophage polarization. Additionally, the impact of these Zn2+-exposed macrophages on gingival fibroblasts incubated in conditioned medium showed stimulated adhesion, proliferation, and collagen secretion. CONCLUSION: Our promising results suggest that controlled release of Zn2+ from Zn/CS/Gel coatings could be applied to immunomodulate peri-implant STI, and to enhance dental implant survival.

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Effects and underlying mechanism of micro-nano-structured zirconia surfaces on biological behaviors of human gingival fibroblasts under inflammatory conditions

Sun,

Ding,

Chen

et al. 2024

Acta Biomaterialia

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Immunomodulation-based development engineering for advancing metal soft tissue implants

Cited by 11 publications

References 152 publications

Soft and Hard Tissue Integration around Percutaneous Bone-Anchored Titanium Prostheses: Toward Achieving Holistic Biointegration

Soft and Hard Tissue Integration around Percutaneous Bone-Anchored Titanium Prostheses: Toward Achieving Holistic Biointegration

Development of Zinc-Containing Chitosan/Gelatin Coatings with Immunomodulatory Effect for Soft Tissue Sealing around Dental Implants

Effects and underlying mechanism of micro-nano-structured zirconia surfaces on biological behaviors of human gingival fibroblasts under inflammatory conditions

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